P38333 · ENP1_YEAST
- ProteinEssential nuclear protein 1
- GeneENP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids483 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunit shifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein.
Miscellaneous
Present with 21600 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | 90S preribosome | |
Cellular Component | cytoplasm | |
Cellular Component | nucleolus | |
Cellular Component | nucleus | |
Cellular Component | preribosome, small subunit precursor | |
Cellular Component | small-subunit processome | |
Molecular Function | snoRNA binding | |
Biological Process | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | maturation of SSU-rRNA | |
Biological Process | poly(A)+ mRNA export from nucleus | |
Biological Process | rRNA processing |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEssential nuclear protein 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP38333
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000186118 | 1-483 | Essential nuclear protein 1 | ||
Modified residue | 172 | Phosphoserine; by ATM or ATR | |||
Modified residue | 190 | Phosphoserine | |||
Modified residue | 404 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P38333 | DHR2 P36009 | 2 | EBI-6482, EBI-5844 | |
BINARY | P38333 | IMP3 P32899 | 5 | EBI-6482, EBI-9237 | |
BINARY | P38333 | IMP4 P53941 | 7 | EBI-6482, EBI-9243 | |
BINARY | P38333 | KAP104 P38217 | 2 | EBI-6482, EBI-9152 | |
BINARY | P38333 | KRR1 P25586 | 6 | EBI-6482, EBI-21773 | |
BINARY | P38333 | NOP1 P15646 | 4 | EBI-6482, EBI-6838 | |
BINARY | P38333 | NOP14 Q99207 | 11 | EBI-6482, EBI-35157 | |
BINARY | P38333 | RRP36 Q12481 | 2 | EBI-6482, EBI-31770 | |
BINARY | P38333 | SLX9 P53251 | 4 | EBI-6482, EBI-23221 | |
BINARY | P38333 | UTP21 Q06078 | 4 | EBI-6482, EBI-359 | |
BINARY | P38333 | UTP22 P53254 | 10 | EBI-6482, EBI-1878 |
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-21 | Disordered | |||
Region | 33-55 | Disordered | |||
Compositional bias | 67-87 | Basic and acidic residues | |||
Region | 67-123 | Disordered | |||
Compositional bias | 95-123 | Acidic residues | |||
Region | 171-200 | Disordered | |||
Compositional bias | 183-197 | Polar residues | |||
Sequence similarities
Belongs to the bystin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length483
- Mass (Da)55,137
- Last updated1994-10-01 v1
- Checksum399A415131294637
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 67-87 | Basic and acidic residues | |||
Compositional bias | 95-123 | Acidic residues | |||
Compositional bias | 183-197 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U50779 EMBL· GenBank· DDBJ | AAC49647.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z36116 EMBL· GenBank· DDBJ | CAA85210.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006936 EMBL· GenBank· DDBJ | DAA07363.1 EMBL· GenBank· DDBJ | Genomic DNA |