P38283 · SLI15_YEAST
- ProteinInner centromere protein-related protein SLI15
- GeneSLI15
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids698 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for high-fidelity chromosome segregation during the later part of each cell cycle in association with the protein kinase IPL1. Stimulates IPL1 kinase activity and facilitates its association with the mitotic spindle. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles.
Miscellaneous
Present with 319 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome passenger complex | |
Cellular Component | cytoplasm | |
Cellular Component | kinetochore | |
Cellular Component | kinetochore microtubule | |
Cellular Component | mitotic spindle | |
Cellular Component | nucleus | |
Cellular Component | spindle microtubule | |
Cellular Component | spindle midzone | |
Molecular Function | protein kinase activator activity | |
Biological Process | activation of protein kinase activity | |
Biological Process | attachment of meiotic spindle microtubules to kinetochore | |
Biological Process | chromosome segregation | |
Biological Process | positive regulation of mitotic cell cycle spindle assembly checkpoint | |
Biological Process | regulation of cytokinesis | |
Biological Process | septin cytoskeleton organization | |
Biological Process | sister chromatid biorientation |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInner centromere protein-related protein SLI15
- Short namesINCENP-related protein SLI15
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP38283
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Associates with the mitotic spindle and the kinetochore (PubMed:11724818).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000071956 | 1-698 | Inner centromere protein-related protein SLI15 | |||
Sequence: MDWAIKAARKKTQRKPGSTRSIIETLDDLNNLTTDAHSEINQRLYESSEWLRNNVYMNTLKYEDKKMEESLISPENTHNKMDVEFPKMKGEYELSNSQNDAAKDVTKTPRNGLHNDKSITPKSLRRKEVTEGMNRFSIHDTNKSPVEPLNSVKVDANESEKSSPWSPYKVEKVLRESSKTSESPINTKRFDNQTWAAKEEMENEPILQALKKAESVKVKPPPNSGIARSQRRSNMFVPLPNKDPLIIQHIPPTKSSGSIPKVRTVKESPIAFKKKSTINSPAIRAVENSDTAGSTKASSVFDRLSSIPTKSFENKISRGNVGHKYSSSSIDLTGSPMKKVSQKFKSINSTDTDMQEALRDIFSVKNKITKNNSPKGKNSRKSSIPRFDKTSLKLTTHKKLAIIAEQKKKSKHSSDVHKTGSRPHSISPTKISVDSSSPSKEVKNYYQSPVRGYLRPTKASISPNKNKNLTTSQTPHRLKIKEKTLRKLSPNIADISKPESRKSKNYRLTNLQLLPPAEAERDDLKKKFDKRLSGIMRSQQEHHRRKQEKQKRMSHLEQDLKKQTSFSNDYKDIRLKESLAPFDNHVRDTINKNTAFSTDNILATINTVDHREIIGNVTPKIASVNDSLPEINTDSEDEASVTLAAWAKSPYLQEQLIRQQDINPQTIFGPIPPLHTDEIFPNPRLNRLKPRQIVPKRS | ||||||
Modified residue | 268 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 489 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated by serine/threonine protein kinase IPL1.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P38283 | BIR1 P47134 | 8 | EBI-20842, EBI-3648 | |
BINARY | P38283 | CDC14 Q00684 | 2 | EBI-20842, EBI-4192 | |
BINARY | P38283 | CLB2 P24869 | 2 | EBI-20842, EBI-4515 | |
BINARY | P38283 | DAM1 P53267 | 2 | EBI-20842, EBI-23268 | |
BINARY | P38283 | IPL1 P38991 | 10 | EBI-20842, EBI-9319 | |
BINARY | P38283 | NBL1 Q3E7Y6 | 5 | EBI-20842, EBI-9513736 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 365-380 | Polar residues | ||||
Sequence: KNKITKNNSPKGKNSR | ||||||
Region | 365-390 | Disordered | ||||
Sequence: KNKITKNNSPKGKNSRKSSIPRFDKT | ||||||
Compositional bias | 405-419 | Basic and acidic residues | ||||
Sequence: EQKKKSKHSSDVHKT | ||||||
Region | 405-444 | Disordered | ||||
Sequence: EQKKKSKHSSDVHKTGSRPHSISPTKISVDSSSPSKEVKN | ||||||
Compositional bias | 420-444 | Polar residues | ||||
Sequence: GSRPHSISPTKISVDSSSPSKEVKN | ||||||
Region | 455-474 | Disordered | ||||
Sequence: RPTKASISPNKNKNLTTSQT | ||||||
Compositional bias | 459-474 | Polar residues | ||||
Sequence: ASISPNKNKNLTTSQT | ||||||
Region | 535-560 | Disordered | ||||
Sequence: IMRSQQEHHRRKQEKQKRMSHLEQDL |
Sequence similarities
Belongs to the INCENP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length698
- Mass (Da)79,186
- Last updated1994-10-01 v1
- Checksum827AC2AB884BA7D1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 365-380 | Polar residues | ||||
Sequence: KNKITKNNSPKGKNSR | ||||||
Compositional bias | 405-419 | Basic and acidic residues | ||||
Sequence: EQKKKSKHSSDVHKT | ||||||
Compositional bias | 420-444 | Polar residues | ||||
Sequence: GSRPHSISPTKISVDSSSPSKEVKN | ||||||
Compositional bias | 459-474 | Polar residues | ||||
Sequence: ASISPNKNKNLTTSQT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X71329 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
S59774 EMBL· GenBank· DDBJ | AAC60557.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z36025 EMBL· GenBank· DDBJ | CAA85115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006936 EMBL· GenBank· DDBJ | DAA07271.1 EMBL· GenBank· DDBJ | Genomic DNA |