P38090 · AGP2_YEAST
- ProteinGeneral amino acid permease AGP2
- GeneAGP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids596 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
General amino acid permease with broad substrate specificity. Can also transport carnitine.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | fungal-type vacuole membrane | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | amino acid transmembrane transporter activity | |
Biological Process | amino acid transmembrane transport | |
Biological Process | positive regulation of (R)-carnitine transmembrane transport | |
Biological Process | positive regulation of polyamine transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGeneral amino acid permease AGP2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP38090
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-94 | Cytoplasmic | ||||
Sequence: MTKERMTIDYENDGDFEYDKNKYKTITTRIKSIEPSEGWLEPSGSVGHINTIPEAGDVHVDEHEDRGSSIDDDSRTYLLYFTETRRKLENRHVQ | ||||||
Transmembrane | 95-115 | Helical | ||||
Sequence: LIAISGVIGTALFVAIGKALY | ||||||
Topological domain | 116-117 | Extracellular | ||||
Sequence: RG | ||||||
Transmembrane | 118-138 | Helical | ||||
Sequence: GPASLLLAFALWCVPILCITV | ||||||
Topological domain | 139-165 | Cytoplasmic | ||||
Sequence: STAEMVCFFPVSSPFLRLATKCVDDSL | ||||||
Transmembrane | 166-186 | Helical | ||||
Sequence: AVMASWNFWFLECVQIPFEIV | ||||||
Topological domain | 187-199 | Extracellular | ||||
Sequence: SVNTIIHYWRDDY | ||||||
Transmembrane | 200-220 | Helical | ||||
Sequence: SAGIPLAVQVVLYLLISICAV | ||||||
Topological domain | 221-227 | Cytoplasmic | ||||
Sequence: KYYGEME | ||||||
Transmembrane | 228-248 | Helical | ||||
Sequence: FWLASFKIILALGLFTFTFIT | ||||||
Topological domain | 249-288 | Extracellular | ||||
Sequence: MLGGNPEHDRYGFRNYGESPFKKYFPDGNDVGKSSGYFQG | ||||||
Transmembrane | 289-309 | Helical | ||||
Sequence: FLACLIQASFTIAGGEYISML | ||||||
Topological domain | 310-326 | Cytoplasmic | ||||
Sequence: AGEVKRPRKVLPKAFKQ | ||||||
Transmembrane | 327-347 | Helical | ||||
Sequence: VFVRLTFLFLGSCLCVGIVCS | ||||||
Topological domain | 348-379 | Extracellular | ||||
Sequence: PNDPDLTAAINEARPGAGSSPYVIAMNNLKIR | ||||||
Transmembrane | 380-400 | Helical | ||||
Sequence: ILPDIVNIALITAAFSAGNAY | ||||||
Topological domain | 401-427 | Cytoplasmic | ||||
Sequence: TYCSSRTFYGMALDGYAPKIFTRCNRH | ||||||
Transmembrane | 428-448 | Helical | ||||
Sequence: GVPIYSVAISLVWALVSLLQL | ||||||
Topological domain | 449-459 | Extracellular | ||||
Sequence: NSNSAVVLNWL | ||||||
Transmembrane | 460-480 | Helical | ||||
Sequence: INLITASQLINFVVLCIVYLF | ||||||
Topological domain | 481-505 | Cytoplasmic | ||||
Sequence: FRRAYHVQQDSLPKLPFRSWGQPYT | ||||||
Transmembrane | 506-526 | Helical | ||||
Sequence: AIIGLVSCSAMILIQGYTVFF | ||||||
Topological domain | 527-534 | Extracellular | ||||
Sequence: PKLWNTQD | ||||||
Transmembrane | 535-555 | Helical | ||||
Sequence: FLFSYLMVFINIGIYVGYKFI | ||||||
Topological domain | 556-596 | Cytoplasmic | ||||
Sequence: WKRGKDHFKNPHEIDFSKELTEIENHEIESSFEKFQYYSKA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000054143 | 1-596 | General amino acid permease AGP2 | |||
Sequence: MTKERMTIDYENDGDFEYDKNKYKTITTRIKSIEPSEGWLEPSGSVGHINTIPEAGDVHVDEHEDRGSSIDDDSRTYLLYFTETRRKLENRHVQLIAISGVIGTALFVAIGKALYRGGPASLLLAFALWCVPILCITVSTAEMVCFFPVSSPFLRLATKCVDDSLAVMASWNFWFLECVQIPFEIVSVNTIIHYWRDDYSAGIPLAVQVVLYLLISICAVKYYGEMEFWLASFKIILALGLFTFTFITMLGGNPEHDRYGFRNYGESPFKKYFPDGNDVGKSSGYFQGFLACLIQASFTIAGGEYISMLAGEVKRPRKVLPKAFKQVFVRLTFLFLGSCLCVGIVCSPNDPDLTAAINEARPGAGSSPYVIAMNNLKIRILPDIVNIALITAAFSAGNAYTYCSSRTFYGMALDGYAPKIFTRCNRHGVPIYSVAISLVWALVSLLQLNSNSAVVLNWLINLITASQLINFVVLCIVYLFFRRAYHVQQDSLPKLPFRSWGQPYTAIIGLVSCSAMILIQGYTVFFPKLWNTQDFLFSYLMVFINIGIYVGYKFIWKRGKDHFKNPHEIDFSKELTEIENHEIESSFEKFQYYSKA |
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P38090 | LSB3 P43603 | 2 | EBI-2362, EBI-22980 | |
BINARY | P38090 | YSC84 P32793 | 2 | EBI-2362, EBI-24460 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length596
- Mass (Da)67,262
- Last updated1994-10-01 v1
- Checksum8658DCDA5A7D6B64
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X75891 EMBL· GenBank· DDBJ | CAA53491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z36001 EMBL· GenBank· DDBJ | CAA85089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006936 EMBL· GenBank· DDBJ | DAA07249.1 EMBL· GenBank· DDBJ | Genomic DNA |