P38050 · PBPF_BACSU

Function

function

Cell wall formation. May be involved in outgrowth of the germinated spore or it could function in the synthesis of the germ cell wall.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site87Proton donor; for transglycosylase activity
Active site359Acyl-ester intermediate; for transpeptidase activity

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1F
  • Short names
    PBP-1F
  • Alternative names
    • Penicillin-binding protein F

Including 2 domains:

  • Recommended name
    Penicillin-insensitive transglycosylase
  • EC number
  • Alternative names
    • Peptidoglycan TGase
  • Recommended name
    Penicillin-sensitive transpeptidase
  • EC number
  • Alternative names
    • DD-transpeptidase

Gene names

    • Name
      pbpF
    • Synonyms
      ponA
    • Ordered locus names
      BSU10110

Organism names

Accessions

  • Primary accession
    P38050

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-12Cytoplasmic
Transmembrane13-33Helical; Signal-anchor for type II membrane protein
Topological domain34-714Extracellular

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000831801-714Penicillin-binding protein 1F

Proteomic databases

Expression

Developmental stage

Expression remains constant during vegetative growth, decreases during early sporulation, and is induced in the forespore during late sporulation.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region49-217Transglycosylase
Region297-592Transpeptidase

Sequence similarities

In the N-terminal section; belongs to the glycosyltransferase 51 family.
In the C-terminal section; belongs to the transpeptidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    714
  • Mass (Da)
    79,265
  • Last updated
    2009-06-16 v2
  • Checksum
    C89C318FA2D81D0E
MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLILHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSVGRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKLLEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDKNKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDKYSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGVEAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDYTPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALALGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQTSWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAVWMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKTLTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANLFSGASYKIVPYNTQTKREGEGTDYVQPKLFSS

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict120in Ref. 1; CAA74517 and 4; AAA71942

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y14083
EMBL· GenBank· DDBJ
CAA74517.1
EMBL· GenBank· DDBJ
Genomic DNA
AL009126
EMBL· GenBank· DDBJ
CAB12851.2
EMBL· GenBank· DDBJ
Genomic DNA
L10630
EMBL· GenBank· DDBJ
AAA71942.1
EMBL· GenBank· DDBJ
Genomic DNA
M97208
EMBL· GenBank· DDBJ
AAA22516.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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