P37339 · LHGD_ECOLI
- ProteinL-2-hydroxyglutarate dehydrogenase
- GenelhgD
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids422 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Catalytic activity
- (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinolThis reaction proceeds in the forward direction.
Cofactor
Pathway
Amino-acid degradation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | (S)-2-hydroxyglutarate dehydrogenase activity | |
Molecular Function | 2-hydroxyglutarate dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Biological Process | L-lysine catabolic process | |
Biological Process | lysine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-2-hydroxyglutarate dehydrogenase
- EC number
- Short namesL2HG dehydrogenase
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP37339
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000169295 | 1-422 | L-2-hydroxyglutarate dehydrogenase | |||
Sequence: MYDFVIIGGGIIGMSTAMQLIDVYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKAQFCLAGNRATKAFCDQNGIRYDNCGKMLVATSDLEMERMRALWERTAANGIEREWLNADELREREPNITGLGGIFVPSSGIVSYRDVTAAMAKIFQSRGGEIIYNAEVSGLNEHKNGVVIRTRQGGEYEASTLISCSGLMADRLVKMLGLEPGFIICPFRGEYFRLAPEHNQIVNHLIYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSFSDTLEILGSSGIRRVLQNHLRSGLGEMKNSLCKSGYLRLVQKYCPRLSLSDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRTIHTCNAPSPAATSAIPIGAHIVSKVQTLLASQSNPGRTLRAARSVDALHAAFNQ |
Proteomic databases
Expression
Induction
Expression is induced by RpoS during carbon starvation and at stationary phase. Is also regulated by cAMP-CRP. Repressed by CsiR. Makes part of the operon glaH-lhgD-gabDTP.
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P37339 | ppiC P0A9L5 | 3 | EBI-555990, EBI-555953 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length422
- Mass (Da)46,082
- Last updated2007-12-04 v3
- Checksum8E13E890B0A7365C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U00096 EMBL· GenBank· DDBJ | AAC75707.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAA16521.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M88334 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |