P37298 · DHSD_YEAST
- ProteinSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
- GeneSDH4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids181 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction.
Miscellaneous
Present with 7920 molecules/cell in log phase SD medium.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | |
Cellular Component | mitochondrion | |
Cellular Component | respiratory chain complex II | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinone binding | |
Biological Process | cellular respiration | |
Biological Process | mitochondrial electron transport, succinate to ubiquinone | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
- Short namesCybS
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP37298
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 32-66 | Mitochondrial matrix | ||||
Sequence: LTIPFLPVLPQKPGGVRGTPNDAYVPPPENKLEGS | ||||||
Transmembrane | 67-88 | Helical | ||||
Sequence: YHWYMEKIFALSVVPLATTAML | ||||||
Topological domain | 89-98 | Mitochondrial intermembrane | ||||
Sequence: TTGPLSTAAD | ||||||
Transmembrane | 99-118 | Helical | ||||
Sequence: SFFSVMLLGYCYMEFNSCIT | ||||||
Topological domain | 119-127 | Mitochondrial matrix | ||||
Sequence: DYISERVYG | ||||||
Transmembrane | 128-148 | Helical | ||||
Sequence: VWHKYAMYMLGLGSAVSLFGI | ||||||
Topological domain | 149-181 | Mitochondrial intermembrane | ||||
Sequence: YKLETENDGVVGLVKSLWDSSEKDNSQKIEAKK |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 100 | Impairs respiratory growth and reduces quinone reductase activity. | ||||
Sequence: F → V | ||||||
Mutagenesis | 102 | Impairs respiratory growth and reduces quinone reductase activity. | ||||
Sequence: S → A | ||||||
Mutagenesis | 109 | Decreases SDH cytochrome b content. | ||||
Sequence: C → A | ||||||
Mutagenesis | 120 | Abolishes quinone reductase activity. Little effect on complex assembly. | ||||
Sequence: Y → C | ||||||
Mutagenesis | 130 | Reduces SDHFAD content. Probably impairs complex assembly. | ||||
Sequence: H → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-31 | Mitochondrion | ||||
Sequence: MMLPRSMKFMTGRRIFHTATVRAFQSTAKKS | ||||||
Chain | PRO_0000006496 | 32-181 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | |||
Sequence: LTIPFLPVLPQKPGGVRGTPNDAYVPPPENKLEGSYHWYMEKIFALSVVPLATTAMLTTGPLSTAADSFFSVMLLGYCYMEFNSCITDYISERVYGVWHKYAMYMLGLGSAVSLFGIYKLETENDGVVGLVKSLWDSSEKDNSQKIEAKK |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length181
- Mass (Da)20,249
- Last updated1994-10-01 v1
- Checksum80D76A32E7E6DA70
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L26333 EMBL· GenBank· DDBJ | AAA19637.1 EMBL· GenBank· DDBJ | Unassigned RNA | ||
Z46727 EMBL· GenBank· DDBJ | CAA86683.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY557671 EMBL· GenBank· DDBJ | AAS55997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006938 EMBL· GenBank· DDBJ | DAA12020.1 EMBL· GenBank· DDBJ | Genomic DNA |