P37285 · KLC1_RAT
- ProteinKinesin light chain 1
- GeneKlc1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids560 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:19861499).
The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (PubMed:19861499).
The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (PubMed:19861499).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | ciliary rootlet | |
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic vesicle | |
Cellular Component | cytosol | |
Cellular Component | growth cone | |
Cellular Component | kinesin complex | |
Cellular Component | membrane | |
Cellular Component | membrane-bounded organelle | |
Cellular Component | microtubule | |
Cellular Component | neuron projection | |
Cellular Component | neuronal cell body | |
Cellular Component | vesicle | |
Molecular Function | kinesin binding | |
Molecular Function | tubulin binding | |
Biological Process | axo-dendritic transport | |
Biological Process | cell adhesion | |
Biological Process | intracellular protein transport | |
Biological Process | microtubule-based movement | |
Biological Process | protein localization to synapse | |
Biological Process | stress granule disassembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKinesin light chain 1
- Short namesKLC 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP37285
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000215094 | 1-560 | Kinesin light chain 1 | |||
Sequence: MHDNMSTMVYMKEEKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDSDSSKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGSSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAALRSRKQGLDNVHKQRVAEVLNDPENVEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGMRKMKLGLVK | ||||||
Modified residue | 162 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 449 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 460 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 521 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 524 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylation at Ser-460 by ERK inhibits interaction with CLSTN1 and localization to cytoplasmic vesicles.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain (at protein level).
Gene expression databases
Interaction
Subunit
Oligomeric complex composed of two heavy chains and two light chains (Probable). Interacts with SPAG9 (By similarity).
Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (PubMed:19861499).
Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex (PubMed:14970196).
Interacts with BORCS5 (By similarity).
Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (PubMed:21775604).
Interacts with CLSTN1; phosphorylation at Ser-460 inhibits interaction with CLSTN1 (By similarity).
Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (PubMed:19861499).
Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex (PubMed:14970196).
Interacts with BORCS5 (By similarity).
Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (PubMed:21775604).
Interacts with CLSTN1; phosphorylation at Ser-460 inhibits interaction with CLSTN1 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | P37285 | OPG164 P68619 | 4 | EBI-917396, EBI-7133540 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, compositional bias, region, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 27-156 | |||||
Sequence: KTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKK | ||||||
Compositional bias | 156-178 | Basic and acidic residues | ||||
Sequence: KYDDDISPSEDKDSDSSKEPLDD | ||||||
Region | 156-203 | Disordered | ||||
Sequence: KYDDDISPSEDKDSDSSKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQ | ||||||
Compositional bias | 187-201 | Polar residues | ||||
Sequence: PGQGIQQQHSSAAAA | ||||||
Repeat | 213-246 | TPR 1 | ||||
Sequence: LRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKT | ||||||
Repeat | 255-288 | TPR 2 | ||||
Sequence: ATMLNILALVYRDQNKYKDAANLLNDALAIREKT | ||||||
Repeat | 297-330 | TPR 3 | ||||
Sequence: AATLNNLAVLYGKRGKYKEAEPLCKRALEIREKV | ||||||
Repeat | 339-372 | TPR 4 | ||||
Sequence: AKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTK | ||||||
Repeat | 381-414 | TPR 5 | ||||
Sequence: AKTKNNLASCYLKQGKFKQAETLYKEILTRAHER | ||||||
Repeat | 464-497 | TPR 6 | ||||
Sequence: TTTLKNLGALYRRQGKFEAAETLEEAALRSRKQG |
Sequence similarities
Belongs to the kinesin light chain family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
P37285-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameC
- Length560
- Mass (Da)63,745
- Last updated2008-11-25 v2
- Checksum24D0C4CF9E304366
P37285-2
- NameA
- Differences from canonical
- 542-560: VSMSVEWNGMRKMKLGLVK → A
P37285-3
- NameB
- Differences from canonical
- 542-550: Missing
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8L2RC24 | A0A8L2RC24_RAT | Klc1 | 565 | ||
A0A140TAB3 | A0A140TAB3_RAT | Klc1 | 552 | ||
A0A8L2QTG3 | A0A8L2QTG3_RAT | Klc1 | 551 | ||
A0A8I5ZN87 | A0A8I5ZN87_RAT | Klc1 | 593 | ||
A0A8I5ZU72 | A0A8I5ZU72_RAT | Klc1 | 585 |
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 156-178 | Basic and acidic residues | ||||
Sequence: KYDDDISPSEDKDSDSSKEPLDD | ||||||
Compositional bias | 187-201 | Polar residues | ||||
Sequence: PGQGIQQQHSSAAAA | ||||||
Alternative sequence | VSP_002871 | 542-550 | in isoform B | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_002872 | 542-560 | in isoform A | |||
Sequence: VSMSVEWNGMRKMKLGLVK → A |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M75146 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
M75147 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
M75148 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |