P36773 · LON1_MYXXA
- ProteinLon protease 1
- Genelon1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids817 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Catalytic activity
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 368-375 | ATP (UniProtKB | ChEBI) | |||
Active site | 691 | ||||
Active site | 734 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | cellular response to heat | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLon protease 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Myxococcaceae > Myxococcus
Accessions
- Primary accessionP36773
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000076142 | 1-817 | Lon protease 1 | ||
Expression
Induction
By heat shock.
Developmental stage
Expressed during vegetative growth.
Interaction
Subunit
Homohexamer. Organized in a ring with a central cavity.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 18-216 | Lon N-terminal | |||
Domain | 604-785 | Lon proteolytic | |||
Region | 789-817 | Disordered | |||
Sequence similarities
Belongs to the peptidase S16 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length817
- Mass (Da)91,815
- Last updated1994-06-01 v1
- MD5 Checksum1AC1F33CC1B9CBE5619B91460FB764E1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D12923 EMBL· GenBank· DDBJ | BAA02307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF127082 EMBL· GenBank· DDBJ | AAD31005.1 EMBL· GenBank· DDBJ | Genomic DNA |