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P36773 · LON1_MYXXA

  • Protein
    Lon protease 1
  • Gene
    lon1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1817100200300400500600700800
Type
IDPosition(s)Description
Binding site368-375ATP (UniProtKB | ChEBI)
Active site691
Active site734

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Biological Processcellular response to heat
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease 1
  • EC number
  • Alternative names
    • ATP-dependent protease La 1

Gene names

    • Name
      lon1
    • Synonyms
      lonV

Organism names

  • Taxonomic identifier
  • Strain
    • DZF1
  • Taxonomic lineage
    Bacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Myxococcaceae > Myxococcus

Accessions

  • Primary accession
    P36773

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000761421-817Lon protease 1

Expression

Induction

By heat shock.

Developmental stage

Expressed during vegetative growth.

Interaction

Subunit

Homohexamer. Organized in a ring with a central cavity.

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain18-216Lon N-terminal
Domain604-785Lon proteolytic
Region789-817Disordered

Sequence similarities

Belongs to the peptidase S16 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    817
  • Mass (Da)
    91,815
  • Last updated
    1994-06-01 v1
  • MD5 Checksum
    1AC1F33CC1B9CBE5619B91460FB764E1
MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDIFHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDAFFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRIPPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQDRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDEAEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMFICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPALRTIIHRYTRESGVRSLEREIGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGMAEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITGKLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEITLRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLREALVLEKPEEFGRKPTTDGGKLGGTTELPASPAVAPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D12923
EMBL· GenBank· DDBJ
BAA02307.1
EMBL· GenBank· DDBJ
Genomic DNA
AF127082
EMBL· GenBank· DDBJ
AAD31005.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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