P36712 · CAP3_ADE12

Function

function

Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Features

Showing features for site.

158250100150200250300350400450500550
TypeIDPosition(s)Description
Site565-566Cleavage; by viral protease

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid, decoration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pre-hexon-linking protein IIIa
  • Alternative names
    • Capsid vertex-specific component IIIa
      (CVSC
      )
    • Protein IIIa
    • pIIIa
  • Cleaved into 1 chains

Gene names

    • ORF names
      L1

Organism names

Accessions

  • Primary accession
    P36712

Proteomes

Subcellular Location

Virion
Host nucleus
Note: Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, propeptide.

TypeIDPosition(s)Description
ChainPRO_00004213881-565Hexon-linking protein IIIa
ChainPRO_00002218361-582Pre-hexon-linking protein IIIa
Modified residue233Phosphoserine; by host
Modified residue282Phosphothreonine; by host
Modified residue458Phosphoserine; by host
Modified residue465Phosphoserine; by host
Modified residue482Phosphotyrosine; by host
Modified residue503Phosphoserine; by host
PropeptidePRO_0000421387566-582

Post-translational modification

Cleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-114Peripentonal hexon-tethering domain
Region146-259Binding to hexon-linking protein
Region437-479Disordered
Compositional bias453-478Polar residues
Region517-582Disordered

Sequence similarities

Belongs to the adenoviridae hexon-linking protein IIIa family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    582
  • Mass (Da)
    64,787
  • Last updated
    1994-06-01 v1
  • Checksum
    8341875AE9A267F1
MQRPAIIAERAPNLDPAVLAAMQSQPSGVTASDDWTAAMDRIMALTARSPDAFRQQPQANRFSAILEAVVPSRTNPTHEKVLTIVNALLDSKAIRKDEAGLIYNALLERVARYNSTNVQANLDRMGTDVKEALAQRERFHRDGNLGSLVALNAFLSTQPANVPRGQEDYTNFISALRLMVTEVPQSEVYQSGPDYFFQTSRQGLQTVNLTQAFKNLQGLWGVRAPVGDRSTLSSLLTPNSRLLLLLIAPFTNTNSLSRDSYLGHLVTLYREAIGQAQVDEQTYQEITSVSRALGQEDTGSLEATLNFLLTNRRQQVPPQYTLNAEEERILRYVQQSVSLYLMREGATPSAALDMTARNMEPSFYASNRAFINRLMDYLHRAAAMNGEYFTNAILNPHWLPPPGFYTGEFDLPEGNDGFLWDDVTDSLFSPAVIGHHGKKEAGDEGPLLDSRASSPFPSLTSLPASVNSGRTTRPRLTGESEYLNDPILFPVRDKNFPNNGIESLVDKMSRWKTYAQERREWEERQPRPVRPPRQRWQRRKKGAHAGDEGSDDSADDSSVLDLGGSGNPFAHLRPQGCIGSLY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias453-478Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X73487
EMBL· GenBank· DDBJ
CAA51886.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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