P36568 · BIOA_SERMA

  • Protein
    Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  • Gene
    bioA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.

Features

Showing features for site, binding site.

TypeIDPosition(s)Description
Site19Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Binding site54substrate
Binding site114-115pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site146substrate
Binding site248pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site277substrate
Binding site310substrate
Binding site311-312pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site394substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenosylmethionine-8-amino-7-oxononanoate transaminase activity
Molecular Functionpyridoxal phosphate binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  • EC number
  • Alternative names
    • 7,8-diamino-pelargonic acid aminotransferase
      (DAPA AT
      ; DAPA aminotransferase
      )
    • 7,8-diaminononanoate synthase
      (DANS
      )
    • Diaminopelargonic acid synthase

Gene names

    • Name
      bioA

Organism names

  • Taxonomic identifier
  • Strain
    • Sr41 / TLr156
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Serratia

Accessions

  • Primary accession
    P36568

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001203761-425Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Modified residue277N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    425
  • Mass (Da)
    46,867
  • Last updated
    1994-06-01 v1
  • Checksum
    8BA657E59BB94AF6
MSVTASDLAFDQRHIWHPYTSMSRPLPCYPIESASGVELQLADGRSLVDGMSSWWAAIHGYNHPRLNQAASQQLEKMSHVMFGGITHPAAISLCRRLVEMTPEALQCVFLADSGSVAVEVSLKMALQYWQARGERRQRILTLRHGYHGDTFGAMSVCDPDNSMHSLYQGYLAPHLFATAPQCRFDEEWREEDIAPFAALLEQHAGEVAAVILEPVVQGAGGMRIYHPTYLKRVRDVVRVAIKLLLIADEIATGFGRTGKLFACEHAQVVPDILCLGKALTGGYMTLSATLTTRHVAETISNGAAGCFMHGPTFMGNPLACAVADASLALLAENRWQAQVSAIETQLKRELLPLGRCRRWPHVRVLGAIGVVEMREPVDVAELQRGFVERGVWIRPFGKLIYLMPPYIIEAEQLSRLTAAVADAAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D17468
EMBL· GenBank· DDBJ
BAA04284.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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