P36344 · VGLJ_CHV1
- ProteinEnvelope glycoprotein J
- GenegJ
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids117 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell endoplasmic reticulum membrane | |
Cellular Component | host cell endosome membrane | |
Cellular Component | host cell Golgi membrane | |
Cellular Component | membrane |
Names & Taxonomy
Protein names
- Recommended nameEnvelope glycoprotein J
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus macacinealpha1
- Virus hosts
Accessions
- Primary accessionP36344
Subcellular Location
UniProt Annotation
GO Annotation
Host Golgi apparatus membrane ; Single-pass type I membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host endosome membrane ; Single-pass type I membrane protein
Note: Localizes to the endoplasmic reticulum, trans-Golgi network, and early endosomes.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 27-73 | Extracellular | ||||
Sequence: TGTTPTVGANSTADPGTGANGTTVPAAGTPANSTTAAETPAPFPPVD | ||||||
Transmembrane | 74-94 | Helical | ||||
Sequence: FALPVVIGGLCALTLAAMGAG | ||||||
Topological domain | 95-117 | Cytoplasmic | ||||
Sequence: ALLHRCCRRAAARRRQRAAYVYA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MRSLLFVVGAWVAAAVTHLTPNAALA | ||||||
Chain | PRO_0000115791 | 27-117 | Envelope glycoprotein J | |||
Sequence: TGTTPTVGANSTADPGTGANGTTVPAAGTPANSTTAAETPAPFPPVDFALPVVIGGLCALTLAAMGAGALLHRCCRRAAARRRQRAAYVYA | ||||||
Glycosylation | 36 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 46 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 58 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 26-64 | Disordered | ||||
Sequence: ATGTTPTVGANSTADPGTGANGTTVPAAGTPANSTTAAE |
Sequence similarities
Belongs to the alphaherpesvirinae glycoprotein J family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length117
- Mass (Da)11,614
- Last updated1994-06-01 v1
- ChecksumD16D4D2551ADFA2F