P36310 · CAPSD_PAVL3
- ProteinCapsid protein VP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids729 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell | |
Cellular Component | host cell nucleus | |
Cellular Component | T=1 icosahedral viral capsid | |
Molecular Function | metal ion binding | |
Molecular Function | structural molecule activity | |
Biological Process | clathrin-dependent endocytosis of virus by host cell | |
Biological Process | microtubule-dependent intracellular transport of viral material towards nucleus | |
Biological Process | symbiont entry into host cell via permeabilization of host membrane | |
Biological Process | viral penetration into host nucleus | |
Biological Process | virion attachment to host cell |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCapsid protein VP1
- Alternative names
Organism names
- Organism
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Quintoviricetes > Piccovirales > Parvoviridae > Parvovirinae > Protoparvovirus > Protoparvovirus rodent1
- Virus hosts
Accessions
- Primary accessionP36310
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000222460 | 1-729 | Capsid protein VP1 | |||
Sequence: MAPPAKRAKRGWVPPGYKYLGPGNSLNQGEPTNPSDAAAKEHDEAYDQYIKSGKNPYLYFSPADQRFIDQTKDAKDWGGKVGHYFFRTKRAFAPKLSTDSEPGTSGVSTAGKRTKPPAHIFINQARAKKKRTSLAAQQRTQTMSDGTDQSDSGNAVQSAARVERAADGPGGSGGGGSGGGGVGVSTGSYDNQTHYKFLGDGWVEITAYSTRMVHLNMPKSENYCRVRVHNTNDTGTASHMAMDDAHEQIWTPWSLVDANAWGVWFQPSDWQYISNNMIHINLHSLDQELFNVVIKTVTEQNTGAEAIKVYNNDLTAAMMVALDSNNILPYTPAIDNQETLGFYPWKPTIPSPYRYYFSCDRNLSVTYKDEAGTITDTMGLASGLNSQFFTIENTQRINLLRTGDEYATGTYYFDTEPIRLTHTWQTNRHLGQPPQITELPSSDTANATLTARGYRSGLTQIQGRNDVTEATRVRPAQVGFCQPHDNFETSRAGPFKVPVVPADITQGLDHDANGSLRYTYDKQHGQSWASQNNKDRYTWDAVNYDSGRWTNNCFIQSVPFTSEPNANQILTNRDNLAGKTDIHFTNAFNSYGPLTAFPHPAPIYPQGQIWDKELDLEHKPRLHTQAPFVCKNNAPGQLLVRLAPNLTDQYDPNSSNLSRIVTYGTFFWKGKLTLKAKMRPNATWNPVFQISATNQGTNDYMSIERWLPTATGNITNVPLLSRPVARNTY |
Family & Domains
Features
Showing features for region, motif, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: MAPPAKRAKRGWVPPGYKYLGPGNSLNQGEPTNPSDA | ||||||
Motif | 4-13 | Nuclear localization signal | ||||
Sequence: PAKRAKRGWV | ||||||
Region | 19-64 | Phospholipase A2-like | ||||
Sequence: YLGPGNSLNQGEPTNPSDAAAKEHDEAYDQYIKSGKNPYLYFSPAD | ||||||
Region | 95-185 | Disordered | ||||
Sequence: KLSTDSEPGTSGVSTAGKRTKPPAHIFINQARAKKKRTSLAAQQRTQTMSDGTDQSDSGNAVQSAARVERAADGPGGSGGGGSGGGGVGVS | ||||||
Compositional bias | 130-157 | Polar residues | ||||
Sequence: KRTSLAAQQRTQTMSDGTDQSDSGNAVQ |
Domain
The N-terminus of VP1 is sequestered within the mature capsid. It contains a phospholipase A2-like region and putative nuclear localization signals.
Sequence similarities
Belongs to the parvoviridae capsid protein family.
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P36310-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameVP1
- NoteMinor splicing isoform.
- Length729
- Mass (Da)81,125
- Last updated2011-05-31 v2
- Checksum56A59A50E5BCDE43
P36310-2
- NameVP2
- NoteMajor splicing isoform produced by deletion of the initiating AUG for VP1 and downstream translation of VP2.
- Differences from canonical
- 1-142: Missing
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_041141 | 1-142 | in isoform VP2 | |||
Sequence: Missing | ||||||
Compositional bias | 130-157 | Polar residues | ||||
Sequence: KRTSLAAQQRTQTMSDGTDQSDSGNAVQ |
Keywords
- Coding sequence diversity
- Technical term