P36310 · CAPSD_PAVL3

  • Protein
    Capsid protein VP1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).

Features

Showing features for binding site.

1729100200300400500600700
TypeIDPosition(s)Description
Binding site325Mg2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleus
Cellular ComponentT=1 icosahedral viral capsid
Molecular Functionmetal ion binding
Molecular Functionstructural molecule activity
Biological Processclathrin-dependent endocytosis of virus by host cell
Biological Processmicrotubule-dependent intracellular transport of viral material towards nucleus
Biological Processsymbiont entry into host cell via permeabilization of host membrane
Biological Processviral penetration into host nucleus
Biological Processvirion attachment to host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Capsid protein VP1
  • Alternative names
    • Coat protein VP1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Quintoviricetes > Piccovirales > Parvoviridae > Parvovirinae > Protoparvovirus > Protoparvovirus rodent1
  • Virus hosts

Accessions

  • Primary accession
    P36310

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002224601-729Capsid protein VP1

Family & Domains

Features

Showing features for region, motif, compositional bias.

TypeIDPosition(s)Description
Region1-37Disordered
Motif4-13Nuclear localization signal
Region19-64Phospholipase A2-like
Region95-185Disordered
Compositional bias130-157Polar residues

Domain

The N-terminus of VP1 is sequestered within the mature capsid. It contains a phospholipase A2-like region and putative nuclear localization signals.

Sequence similarities

Belongs to the parvoviridae capsid protein family.

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P36310-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    VP1
  • Note
    Minor splicing isoform.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    729
  • Mass (Da)
    81,125
  • Last updated
    2011-05-31 v2
  • Checksum
    56A59A50E5BCDE43
MAPPAKRAKRGWVPPGYKYLGPGNSLNQGEPTNPSDAAAKEHDEAYDQYIKSGKNPYLYFSPADQRFIDQTKDAKDWGGKVGHYFFRTKRAFAPKLSTDSEPGTSGVSTAGKRTKPPAHIFINQARAKKKRTSLAAQQRTQTMSDGTDQSDSGNAVQSAARVERAADGPGGSGGGGSGGGGVGVSTGSYDNQTHYKFLGDGWVEITAYSTRMVHLNMPKSENYCRVRVHNTNDTGTASHMAMDDAHEQIWTPWSLVDANAWGVWFQPSDWQYISNNMIHINLHSLDQELFNVVIKTVTEQNTGAEAIKVYNNDLTAAMMVALDSNNILPYTPAIDNQETLGFYPWKPTIPSPYRYYFSCDRNLSVTYKDEAGTITDTMGLASGLNSQFFTIENTQRINLLRTGDEYATGTYYFDTEPIRLTHTWQTNRHLGQPPQITELPSSDTANATLTARGYRSGLTQIQGRNDVTEATRVRPAQVGFCQPHDNFETSRAGPFKVPVVPADITQGLDHDANGSLRYTYDKQHGQSWASQNNKDRYTWDAVNYDSGRWTNNCFIQSVPFTSEPNANQILTNRDNLAGKTDIHFTNAFNSYGPLTAFPHPAPIYPQGQIWDKELDLEHKPRLHTQAPFVCKNNAPGQLLVRLAPNLTDQYDPNSSNLSRIVTYGTFFWKGKLTLKAKMRPNATWNPVFQISATNQGTNDYMSIERWLPTATGNITNVPLLSRPVARNTY

P36310-2

  • Name
    VP2
  • Note
    Major splicing isoform produced by deletion of the initiating AUG for VP1 and downstream translation of VP2.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0411411-142in isoform VP2
Compositional bias130-157Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M81888
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

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