P36304 · POLN_KYMVJ

Function

function

Methyltransferase/Protease

Acts as a cysteine protease, methyltransferase and deubiquitinase (By similarity).
The cysteine protease activity cleaves the polyprotein giving rise to mature proteins (By similarity).
The methyltransferase domain is probably involved in viral RNA capping (By similarity).

RNA-directed RNA polymerase

RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.

Catalytic activity

Features

Showing features for active site, site, binding site.

118742004006008001,0001,2001,4001,6001,800
TypeIDPosition(s)Description
Active site810For protease activity
Active site896For protease activity
Site905-906Cleavage; by viral protease
Binding site1002-1009ATP (UniProtKB | ChEBI)
Site1288-1289Cleavage; by viral protease

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionmRNA methyltransferase activity
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processmethylation
Biological ProcessmRNA modification
Biological Processproteolysis
Biological ProcessRNA processing
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processviral RNA genome replication

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    P36304

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004609881-?905Methyltransferase/Protease
ChainPRO_00002229351-1874Non-structural replication polyprotein
ChainPRO_0000460989?906-?1288Putative helicase
ChainPRO_0000460990?1289-1874RNA-directed RNA polymerase

Post-translational modification

Specific enzymatic cleavages by the host yield mature proteins.

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain58-219Alphavirus-like MT
Compositional bias619-639Pro residues
Region619-760Disordered
Compositional bias663-687Polar residues
Compositional bias688-709Pro residues
Compositional bias710-751Polar residues
Domain757-912Peptidase C21
Domain972-1129+RNA virus helicase ATP-binding
Domain1130-1266+RNA virus helicase C-terminal
Domain1601-1707RdRp catalytic

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,874
  • Mass (Da)
    210,030
  • Last updated
    1994-06-01 v1
  • Checksum
    72B6DDE57732A2AD
MAFQLALDALASTSHKDPSLHPVLESVHDSLTDSLQTYPWMVPQDLQPFLLKSGIPINSFGSSPHPHPAHKTLETHLLFTHWMHLCTQPSSVLFMKPQKFMKLQRKNKFFQHLHNYRLTPTDSVRFPSTSPHLPNTPFVFMHDALMYYQPEQILHLFHQVPQLTNLFCSLVTPPESHFTHLSLMPDLYTFTLKGQTLHYTPEGHSAGSYNQPITALSWLKINSILSPNLNLSITILESWGPLHSILIQRGLPLPDPKLLVRSLPPFSRSPDPETDLVSFQVPKSVELPQATFLSQPLRHRLVPESVYNALFTYTRAVRTLRVSDPAGFVRTQSNKPEHKWVTPSAWDNLQTFALLNCPLRPNVVYHVLLNPLQKMKLYFSQHWRRLGVIAAPGLFCLSLLLRSQKWSLPLPKAKSISVFRRNLLLPPKPHRPPLLPHPEQMLQEFKLPWHRPPPKGKRNPFLTLLINLLHIPREICAGIRRYPSYYQSIQPKPLNPIQQFRNQLLAQLHTLPLPKKFLSILPRARKDIPLLPRMSFTTVNLPLQPPMWLAIGASLVPELAFLLSWLSGDVDLQTQHDIYHHHLHPENFTLSWTRTPYLALAPSPFLPYAHSPLPPLPVNSSPLFPPPPPLPPSQPPLSQGPATQAPSAQPTPGEPLLAPPTTELKPESSNPNNPNPSSSAGSNPPPKSSSSDNPPAPNKPTPTSSSTTPPSPNLPLQFGSIHSPFLSDGQLNYSALPPPQDPTNTTLSLLPEPKPPTEVQSPLMADPTCVGPAVSFSSLYPRDFFPNTASFLTRLRLSPPTPLPMPKNNCLLTAVAPSLHINPHRLWTSLQEVLPDSLLSNSEIDSVGMSTDLLTALSHLFNFQAVVHSERGDILFGLQSAKTVIHIYHTNGPPAHYSPPPKIIGSNSPPSSQQHPLEQAALRFKYQGSHLPFSSFHSFTTSVQHAKNLISNMKNGFDGVMSTIEPSIRHQPGHSPREKFIALDAMIDLARPKTVSMFHLAGFAGCGKTKPLQSLLSTRPFHSFRVSTPTTELRNEWKKDMNLPASQAFRFCTWESSLLKQTKILVIDEIYKLPRGYLDLCILADPCLELVIILGDPLQGEYHSTSPHSSNHQLQSETTRLLPFIDHYCWWTYRVPSHIADLFSVPSFNRSEGHYQMAVRTADSYTPGHFNLVNSVATANAVIQLGFPATTISASQGVTHHNRVTILLDKHSRLLSPSNTLVALTRSTVGVEFLGDIGSLSGTNNSSDMFSRAIYRQPINLSSSFPRIFHLLPLLNKPISRRSTRLIGSHSPIFHNPRLTNIHLPPHIPTSYSQDFVVSNPIFQGQADPRLDTHFLPPTRLPLQSELLPAQLSQTTKPTDSFTNNTPFTPVYPGENFENLAAFFLPAHDPELKEVTRRDQTSAQFPWFDRPFSLSCQPSSLIAAKHSPSQDPTLLPFSIPKRLRFRKSDNPHVLSAIDVLLGNQLFFNLCKAYRRNPTHVGPFNPALFAECIALNDYAQLSSKTQATLVANHSRSDPDWRHTAVKIFAKSQHKVNDASIFGNWKACQTLALMHDFVILSLGPVKKYQRIFDALDRPPHLYTHCGKSPADLSAWCQTHLTGQIKLTNDYTAFDQSQHGESVILEALKMKRLSIPSHLIQLHVHLKTNVATQFGPLTCMRLTGEPGTYDDNSDYNLAVIHSQFDMKDIPVMVSGDDSLIDRQPPLAQSWEATKRLLHLRFKTEKTTHPLFCGYYTGSAGAIRNPLALFSKLMIAIDDEAIHDRRLSYLTEFSTGHQLGDALWTLLPESTQIYQSACFDYFCRHSPPHEKALLSSFELPDSVISKISSSTKWLSKNAFYALPSKIRKAVIASRHSSSFPENPDVSQLEFELLQSFQF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias619-639Pro residues
Compositional bias663-687Polar residues
Compositional bias688-709Pro residues
Compositional bias710-751Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D00637
EMBL· GenBank· DDBJ
BAA00532.1
EMBL· GenBank· DDBJ
Genomic RNA

Genome annotation databases

Similar Proteins

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