P36123 · SA190_YEAST

Function

function

Positive regulator of protein phosphatase SIT4. Involved in the general amino acid control (GAAC) response regulated by TOR. Involved in the dephosphorylation of the elongator complex subunit IKI3.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentprotein serine/threonine phosphatase complex
Molecular Functionprotein phosphatase binding
Molecular Functionprotein phosphatase regulator activity
Biological ProcessG1/S transition of mitotic cell cycle
Biological Processregulation of phosphoprotein phosphatase activity
Biological ProcessTOR signaling
Biological ProcesstRNA wobble uridine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    SIT4-associating protein SAP190

Gene names

    • Name
      SAP190
    • Ordered locus names
      YKR028W

Organism names

Accessions

  • Primary accession
    P36123
  • Secondary accessions
    • D6VX93

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00000461071-1033SIT4-associating protein SAP190
Modified residue774Phosphoserine
Modified residue857Phosphoserine
Modified residue862Phosphoserine
Modified residue892Phosphoserine
Modified residue990Phosphothreonine
Modified residue991Phosphoserine

Post-translational modification

Hyperphosphorylated in the absence of SIT4.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Associates with the SIT4 protein phosphatase catalytic subunit in a cell-cycle-dependent manner.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P36123SIT4 P206044EBI-16392, EBI-13707

Complex viewer

View interactors in UniProtKB
View CPX-1866 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region32-82Disordered
Compositional bias51-78Basic and acidic residues
Compositional bias147-174Basic and acidic residues
Region147-213Disordered
Compositional bias181-197Basic and acidic residues
Region768-1033Disordered
Compositional bias773-787Basic and acidic residues
Compositional bias795-824Polar residues
Compositional bias856-892Basic and acidic residues
Compositional bias893-921Polar residues
Compositional bias965-979Polar residues
Compositional bias998-1018Acidic residues

Sequence similarities

Belongs to the SAPS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,033
  • Mass (Da)
    117,098
  • Last updated
    1996-10-01 v2
  • Checksum
    33E5575B58B73B1A
MSGSFWKFGQDYSIESPVSKILNSAFIKINKDQDDDVPTGTCEENIADDEDNSSHDYAASEDNVVNENEEKEEENTLPTTESEYENYRPNLDVLDDLLDDDELYTELMCSNFKLLIFLKYPDVLSKLIEYVTNEKILDEETDSAKKPEIIEGVNDHPILIERDRKDKKEDAEEGGDSEETTNDSDHDSGDERSVDSEETSITLPPESEEQVETRRARIAAEILSADVWPISAAIMQNKDLLGRLWSILDHPAPLPIPASTYFMKINERLLDMDITGMLEFILSRDSLVARFLTHVDNPSLMDFLLKVISTDKPDSPTGVIKILKSQELIPKLLDHLNPEYGISTQSAAGDFIKAFVTLSTNSSNELASGIGPNELTRQLVSEEMIEKLIKIMLKGGTSLSNGVGIIIELIRKNNSDYDFIQLVYTTLESHPPTDRDPIHLIHLVKLFAKHMPDFADMLDKTKLPLMEMPFGNIEPLGFERFKICELIAELLHCSNMTLLNEPNGEMIAQERDIERAKELETSTEKENITAIVDNKSSYYDKDCVEKDITENLGALQINNQGSEEDELNDTGVSSVKLDVKSDAKVVEGLENDASGVELYDETLSDTESVRECLREKPLVGDRLKIALEDTKILISILDMFTEFPWNNFLHNVIFDIAQQIFNGPLKTGYNRFLLKDYLVDAYLTKKIVDADKACQDYEKKTGLRYGYMGHLTLVAEEISKFKEYIDEMKLTFCNTAVSDRLEEPFWKEYSETILADTREKYNTVLGDFGNDQESDDDVIRNSDSEDIIGDTEGNENYGNGENDELLSNGHDSGNMDLYYNFNNNENEENEEDYAEYSDVDNKNYYNNVETNDDDYDSDDGKSKSAESEFTDKISEHRDGNSLYNEDNDENGSDKWTSGTSLFPPDHFPSRSQPSDPKLQDQNIFHHQFDFEGVGDDDDYMDPNDDGQSYARPGNPLYTTPKTPPRPKTILFNSLSALDNNGEDEEVALGTSVDDRMDNEISSDEEDSEDEDEENDMGNEEGYSLYRSRSKEAF

Sequence caution

The sequence CAA82100.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias51-78Basic and acidic residues
Compositional bias147-174Basic and acidic residues
Compositional bias181-197Basic and acidic residues
Compositional bias773-787Basic and acidic residues
Compositional bias795-824Polar residues
Compositional bias856-892Basic and acidic residues
Compositional bias893-921Polar residues
Compositional bias965-979Polar residues
Compositional bias998-1018Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U50561
EMBL· GenBank· DDBJ
AAC49304.1
EMBL· GenBank· DDBJ
Genomic DNA
Z28253
EMBL· GenBank· DDBJ
CAA82100.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
BK006944
EMBL· GenBank· DDBJ
DAA09183.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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