P36123 · SA190_YEAST
- ProteinSIT4-associating protein SAP190
- GeneSAP190
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1033 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Positive regulator of protein phosphatase SIT4. Involved in the general amino acid control (GAAC) response regulated by TOR. Involved in the dephosphorylation of the elongator complex subunit IKI3.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | protein serine/threonine phosphatase complex | |
Molecular Function | protein phosphatase binding | |
Molecular Function | protein phosphatase regulator activity | |
Biological Process | G1/S transition of mitotic cell cycle | |
Biological Process | regulation of phosphoprotein phosphatase activity | |
Biological Process | TOR signaling | |
Biological Process | tRNA wobble uridine modification |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSIT4-associating protein SAP190
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP36123
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000046107 | 1-1033 | SIT4-associating protein SAP190 | ||
Modified residue | 774 | Phosphoserine | |||
Modified residue | 857 | Phosphoserine | |||
Modified residue | 862 | Phosphoserine | |||
Modified residue | 892 | Phosphoserine | |||
Modified residue | 990 | Phosphothreonine | |||
Modified residue | 991 | Phosphoserine | |||
Post-translational modification
Hyperphosphorylated in the absence of SIT4.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Associates with the SIT4 protein phosphatase catalytic subunit in a cell-cycle-dependent manner.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P36123 | SIT4 P20604 | 4 | EBI-16392, EBI-13707 |
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 32-82 | Disordered | |||
Compositional bias | 51-78 | Basic and acidic residues | |||
Compositional bias | 147-174 | Basic and acidic residues | |||
Region | 147-213 | Disordered | |||
Compositional bias | 181-197 | Basic and acidic residues | |||
Region | 768-1033 | Disordered | |||
Compositional bias | 773-787 | Basic and acidic residues | |||
Compositional bias | 795-824 | Polar residues | |||
Compositional bias | 856-892 | Basic and acidic residues | |||
Compositional bias | 893-921 | Polar residues | |||
Compositional bias | 965-979 | Polar residues | |||
Compositional bias | 998-1018 | Acidic residues | |||
Sequence similarities
Belongs to the SAPS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,033
- Mass (Da)117,098
- Last updated1996-10-01 v2
- Checksum33E5575B58B73B1A
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 51-78 | Basic and acidic residues | |||
Compositional bias | 147-174 | Basic and acidic residues | |||
Compositional bias | 181-197 | Basic and acidic residues | |||
Compositional bias | 773-787 | Basic and acidic residues | |||
Compositional bias | 795-824 | Polar residues | |||
Compositional bias | 856-892 | Basic and acidic residues | |||
Compositional bias | 893-921 | Polar residues | |||
Compositional bias | 965-979 | Polar residues | |||
Compositional bias | 998-1018 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U50561 EMBL· GenBank· DDBJ | AAC49304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z28253 EMBL· GenBank· DDBJ | CAA82100.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift | |
BK006944 EMBL· GenBank· DDBJ | DAA09183.2 EMBL· GenBank· DDBJ | Genomic DNA |