Deficient expression of a B cell cytoplasmic tyrosine kinase in human X- linked agammaglobulinemia.Tsukada S., Saffran D.C., Rawlings D.J., Parolini O., Allen R.C., Klisak I., Sparkes R.S., Kubagawa H., Mohandas T.[...], Witte O.N.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 72:279-290 (1993)Cited in2Mapped to2
Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells.Yamada N., Kawakami Y., Kimura H., Fukamachi H., Baier G., Altman A., Kato T., Inagaki Y., Kawakami T.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Biophys. Res. Commun. 192:231-240 (1993)Cited in2Mapped to7
Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.Sideras P., Mueller S., Shiels H., Jin H., Khan W.N., Nilsson L., Parkinson E., Thomas J.D., Branden L.[...], Xanthopoulos K.G.View abstractCited forNUCLEOTIDE SEQUENCECategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Immunol. 153:5607-5617 (1994)Cited in1Mapped to2
Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci.Oeltjen J.C., Liu X., Lu J., Allen R.C., Muzny D.M., Belmont J.W., Gibbs R.A.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA]StrainC129CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMamm. Genome 6:334-338 (1995)Cited in6
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.Park H., Wahl M.I., Afar D.E., Turck C.W., Rawlings D.J., Tam C., Scharenberg A.M., Kinet J.P., Witte O.N.View abstractCited forPROTEIN SEQUENCE OF 219-233, PHOSPHORYLATION AT TYR-223, MUTAGENESIS OF TYR-223 AND LYS-430CategoriesPTM / Processing, Sequences, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCImmunity 4:515-525 (1996)Cited in2Mapped to99+
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.Li T., Tsukada S., Satterthwaite A., Havlik M.H., Park H., Takatsu K., Witte O.N.View abstractCited forFUNCTION, MUTAGENESIS OF GLU-41 AND LYS-430CategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCImmunity 2:451-460 (1995)Cited in1
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.Rawlings D.J., Scharenberg A.M., Park H., Wahl M.I., Lin S., Kato R.M., Fluckiger A.C., Witte O.N., Kinet J.P.View abstractCited forFUNCTION, PHOSPHORYLATION AT TYR-551CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 271:822-825 (1996)Cited in2Mapped to99+
Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain.Kojima T., Fukuda M., Watanabe Y., Hamazato F., Mikoshiba K.View abstractCited forDOMAINCategoriesFamily & DomainsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Biophys. Res. Commun. 236:333-339 (1997)Cited in1
Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement.Petro J.B., Rahman S.M., Ballard D.W., Khan W.N.View abstractCited forDISRUPTION PHENOTYPECategoriesPhenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Exp. Med. 191:1745-1754 (2000)Cited in1Mapped to2
The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease.Webb C.F., Yamashita Y., Ayers N., Evetts S., Paulin Y., Conley M.E., Smith E.A.View abstractCited forFUNCTION, INTERACTION WITH ARID3A, SUBCELLULAR LOCATION, CHARACTERIZATION OF VARIANT XID CYS-28CategoriesFunction, Sequences, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Immunol. 165:6956-6965 (2000)Cited in2Mapped to2
Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.Kawakami Y., Kitaura J., Hartman S.E., Lowell C.A., Siraganian R.P., Kawakami T.View abstractCited forFUNCTION, ACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 97:7423-7428 (2000)Cited in1Mapped to7
Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.Rajaiya J., Nixon J.C., Ayers N., Desgranges Z.P., Roy A.L., Webb C.F.View abstractCited forINTERACTION WITH GTF2I AND ARID3A, FUNCTIONCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 26:4758-4768 (2006)Cited in6Mapped to10
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-40; TYR-344 AND TYR-551, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueMast cellCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Immunol. 179:5864-5876 (2007)Cited in99+99+Mapped to1
Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice.Hasan M., Lopez-Herrera G., Blomberg K.E., Lindvall J.M., Berglof A., Smith C.I., Vargas L.View abstractCited forFUNCTION IN THE TLR PATHWAYCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCImmunology 123:239-249 (2008)Cited in1Mapped to3
Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis.Uckun F.M.View abstractCited forREVIEW ON FUNCTION IN REGULATION OF APOPTOSISCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Pharmacol. 56:683-691 (1998)Cited in3
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.Mohamed A.J., Yu L., Backesjo C.M., Vargas L., Faryal R., Aints A., Christensson B., Berglof A., Vihinen M.[...], Smith C.I.View abstractCited forREVIEW ON FUNCTION, REVIEW ON ACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCImmunol. Rev. 228:58-73 (2009)Cited in3
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueSpleenCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.Choi H.K., Kang H.R., Jung E., Kim T.E., Lin J.J., Lee S.Y.View abstractCited forIDENTIFICATION IN A COMPLEX WITH EEIG1; TNFRSF11A; PLCG2; GAB2 AND TEC, SUBCELLULAR LOCATIONCategoriesInteraction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Res. 23:524-536 (2013)Cited in12Mapped to23
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.Bittner Z.A., Liu X., Mateo Tortola M., Tapia-Abellan A., Shankar S., Andreeva L., Mangan M., Spalinger M., Kalbacher H.[...], Weber A.N.R.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Exp. Med. 218:0-0 (2021)Cited in4Mapped to3
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.Rawlings D.J., Saffran D.C., Tsukada S., Largaespada D.A., Grimaldi J.C., Cohen L., Mohr R.N., Bazan J.F., Howard M.[...], Witte O.N.View abstractCited forVARIANT XID CYS-28CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 261:358-361 (1993)Cited in1Mapped to8
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.Fruman D.A., Snapper S.B., Yballe C.M., Davidson L., Yu J.Y., Alt F.W., Cantley L.C.View abstractCategoriesSequencesSourceMGI: 88216PubMedEurope PMCScience 283:393-397 (1999)Mapped to15
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.Suzuki H., Terauchi Y., Fujiwara M., Aizawa S., Yazaki Y., Kadowaki T., Koyasu S.View abstractCategoriesFunctionSourceMGI: 88216PubMedEurope PMCScience 283:390-392 (1999)Mapped to11
Defective degranulation and calcium mobilization of bone-marrow derived mast cells from Xid and Btk-deficient mice.Setoguchi R., Kinashi T., Sagara H., Hirosawa K., Takatsu K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 88216PubMedEurope PMCImmunol Lett 64:109-118 (1998)Mapped to11
Enhanced human tumor cell transplantability in a new congenic immunodeficient mouse; KSN-BNX.Ishigaki Y., Yasuda K., Hashimoto N., Nikaido H., Nikaido O., Hayakawa J.I.View abstractCategoriesFunctionSourceMGI: 88216PubMedEurope PMCFolia Microbiol (Praha) 43:493-494 (1998)Mapped to13
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.Satterthwaite A.B., Lowell C.A., Khan W.N., Sideras P., Alt F.W., Witte O.N.View abstractCategoriesFunctionSourceMGI: 88216PubMedEurope PMCJ Exp Med 188:833-844 (1998)Mapped to8