P35858 · ALS_HUMAN

  • Protein
    Insulin-like growth factor-binding protein complex acid labile subunit
  • Gene
    IGFALS
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular exosome
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentinsulin-like growth factor ternary complex
Molecular Functioninsulin-like growth factor binding
Biological Processcell adhesion
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Insulin-like growth factor-binding protein complex acid labile subunit
  • Short names
    ALS

Gene names

    • Name
      IGFALS
    • Synonyms
      ALS

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P35858
  • Secondary accessions
    • B4DZY8
    • E9PGU3

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Acid-labile subunit deficiency (ACLSD)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A disorder characterized by severely reduced serum IGF-I and IGFBP-3 concentrations and mild growth retardation. Pubertal delay in boys and insulin insensitivity are common findings.
  • See also
    MIM:615961
Natural variants in ACLSD
Variant IDPosition(s)ChangeDescription
VAR_07247560C>Sin ACLSD
VAR_07247673P>Lin ACLSD; dbSNP:rs766004600
VAR_074071127L>Pin ACLSD
VAR_072477134L>Qin ACLSD
VAR_072478197R>RSLRin ACLSD
VAR_072479244L>Fin ACLSD; dbSNP:rs774634302
VAR_072480276N>Sin ACLSD; dbSNP:rs551618643
VAR_072481439L>LLELin ACLSD
VAR_072482440D>Nin ACLSD; dbSNP:rs776840046
VAR_072483540C>Rin ACLSD; dbSNP:rs121909247

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_07247560in ACLSD
Natural variantVAR_07247673in ACLSD; dbSNP:rs766004600
Natural variantVAR_05065897in dbSNP:rs35947557
Natural variantVAR_074071127in ACLSD
Natural variantVAR_072477134in ACLSD
Natural variantVAR_072478197in ACLSD
Natural variantVAR_072479244in ACLSD; dbSNP:rs774634302
Natural variantVAR_072480276in ACLSD; dbSNP:rs551618643
Natural variantVAR_050659307in dbSNP:rs34297640
Natural variantVAR_072481439in ACLSD
Natural variantVAR_072482440in ACLSD; dbSNP:rs776840046
Natural variantVAR_022034498in dbSNP:rs9282730
Natural variantVAR_072483540in ACLSD; dbSNP:rs121909247
Natural variantVAR_022035548in dbSNP:rs9282731

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 969 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000002069528-605Insulin-like growth factor-binding protein complex acid labile subunit
Glycosylation64N-linked (GlcNAc...) asparagine
Glycosylation85N-linked (GlcNAc...) asparagine
Glycosylation96N-linked (GlcNAc...) asparagine
Glycosylation368N-linked (GlcNAc...) asparagine
Glycosylation515N-linked (GlcNAc...) asparagine
Glycosylation580N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Plasma.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, repeat.

TypeIDPosition(s)Description
Domain32-74LRRNT
Repeat75-96LRR 1
Repeat99-120LRR 2
Repeat123-144LRR 3
Repeat147-168LRR 4
Repeat171-192LRR 5
Repeat195-216LRR 6
Repeat219-240LRR 7
Repeat243-264LRR 8
Repeat267-288LRR 9
Repeat291-312LRR 10
Repeat315-336LRR 11
Repeat339-360LRR 12
Repeat363-384LRR 13
Repeat387-408LRR 14
Repeat411-432LRR 15
Repeat435-456LRR 16
Repeat459-480LRR 17
Repeat483-504LRR 18
Repeat507-528LRR 19
Domain536-605LRRCT

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P35858-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    605
  • Mass (Da)
    66,035
  • Last updated
    1994-06-01 v1
  • Checksum
    F6562A23CBE918F6
MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC

P35858-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 5-5: K → KAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H3BSX8H3BSX8_HUMANIGFALS131

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0446055in isoform 2
Sequence conflict10in Ref. 3; BAG64250

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M86826
EMBL· GenBank· DDBJ
AAA36047.1
EMBL· GenBank· DDBJ
mRNA
AF192554
EMBL· GenBank· DDBJ
AAF06774.1
EMBL· GenBank· DDBJ
Genomic DNA
AK303146
EMBL· GenBank· DDBJ
BAG64250.1
EMBL· GenBank· DDBJ
mRNA
AC012180
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL031724
EMBL· GenBank· DDBJ
CAC36078.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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