P35858 · ALS_HUMAN
- ProteinInsulin-like growth factor-binding protein complex acid labile subunit
- GeneIGFALS
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids605 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular exosome | |
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Cellular Component | insulin-like growth factor ternary complex | |
Molecular Function | insulin-like growth factor binding | |
Biological Process | cell adhesion | |
Biological Process | signal transduction |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInsulin-like growth factor-binding protein complex acid labile subunit
- Short namesALS
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP35858
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Acid-labile subunit deficiency (ACLSD)
- Note
- DescriptionA disorder characterized by severely reduced serum IGF-I and IGFBP-3 concentrations and mild growth retardation. Pubertal delay in boys and insulin insensitivity are common findings.
- See alsoMIM:615961
Natural variants in ACLSD
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_072475 | 60 | C>S | in ACLSD | |
VAR_072476 | 73 | P>L | in ACLSD; dbSNP:rs766004600 | |
VAR_074071 | 127 | L>P | in ACLSD | |
VAR_072477 | 134 | L>Q | in ACLSD | |
VAR_072478 | 197 | R>RSLR | in ACLSD | |
VAR_072479 | 244 | L>F | in ACLSD; dbSNP:rs774634302 | |
VAR_072480 | 276 | N>S | in ACLSD; dbSNP:rs551618643 | |
VAR_072481 | 439 | L>LLEL | in ACLSD | |
VAR_072482 | 440 | D>N | in ACLSD; dbSNP:rs776840046 | |
VAR_072483 | 540 | C>R | in ACLSD; dbSNP:rs121909247 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_072475 | 60 | in ACLSD | |||
Sequence: C → S | ||||||
Natural variant | VAR_072476 | 73 | in ACLSD; dbSNP:rs766004600 | |||
Sequence: P → L | ||||||
Natural variant | VAR_050658 | 97 | in dbSNP:rs35947557 | |||
Sequence: L → F | ||||||
Natural variant | VAR_074071 | 127 | in ACLSD | |||
Sequence: L → P | ||||||
Natural variant | VAR_072477 | 134 | in ACLSD | |||
Sequence: L → Q | ||||||
Natural variant | VAR_072478 | 197 | in ACLSD | |||
Sequence: R → RSLR | ||||||
Natural variant | VAR_072479 | 244 | in ACLSD; dbSNP:rs774634302 | |||
Sequence: L → F | ||||||
Natural variant | VAR_072480 | 276 | in ACLSD; dbSNP:rs551618643 | |||
Sequence: N → S | ||||||
Natural variant | VAR_050659 | 307 | in dbSNP:rs34297640 | |||
Sequence: P → L | ||||||
Natural variant | VAR_072481 | 439 | in ACLSD | |||
Sequence: L → LLEL | ||||||
Natural variant | VAR_072482 | 440 | in ACLSD; dbSNP:rs776840046 | |||
Sequence: D → N | ||||||
Natural variant | VAR_022034 | 498 | in dbSNP:rs9282730 | |||
Sequence: P → S | ||||||
Natural variant | VAR_072483 | 540 | in ACLSD; dbSNP:rs121909247 | |||
Sequence: C → R | ||||||
Natural variant | VAR_022035 | 548 | in dbSNP:rs9282731 | |||
Sequence: R → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 969 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MALRKGGLALALLLLSWVALGPRSLEG | ||||||
Chain | PRO_0000020695 | 28-605 | Insulin-like growth factor-binding protein complex acid labile subunit | |||
Sequence: ADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC | ||||||
Glycosylation | 64 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 85 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 96 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 368 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 515 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 580 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-74 | LRRNT | ||||
Sequence: TPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPG | ||||||
Repeat | 75-96 | LRR 1 | ||||
Sequence: GTQALWLDGNNLSSVPPAAFQN | ||||||
Repeat | 99-120 | LRR 2 | ||||
Sequence: SLGFLNLQGGQLGSLEPQALLG | ||||||
Repeat | 123-144 | LRR 3 | ||||
Sequence: NLCHLHLERNQLRSLALGTFAH | ||||||
Repeat | 147-168 | LRR 4 | ||||
Sequence: ALASLGLSNNRLSRLEDGLFEG | ||||||
Repeat | 171-192 | LRR 5 | ||||
Sequence: SLWDLNLGWNSLAVLPDAAFRG | ||||||
Repeat | 195-216 | LRR 6 | ||||
Sequence: SLRELVLAGNRLAYLQPALFSG | ||||||
Repeat | 219-240 | LRR 7 | ||||
Sequence: ELRELDLSRNALRAIKANVFVQ | ||||||
Repeat | 243-264 | LRR 8 | ||||
Sequence: RLQKLYLDRNLIAAVAPGAFLG | ||||||
Repeat | 267-288 | LRR 9 | ||||
Sequence: ALRWLDLSHNRVAGLLEDTFPG | ||||||
Repeat | 291-312 | LRR 10 | ||||
Sequence: GLRVLRLSHNAIASLRPRTFKD | ||||||
Repeat | 315-336 | LRR 11 | ||||
Sequence: FLEELQLGHNRIRQLAERSFEG | ||||||
Repeat | 339-360 | LRR 12 | ||||
Sequence: QLEVLTLDHNQLQEVKAGAFLG | ||||||
Repeat | 363-384 | LRR 13 | ||||
Sequence: NVAVMNLSGNCLRNLPEQVFRG | ||||||
Repeat | 387-408 | LRR 14 | ||||
Sequence: KLHSLHLEGSCLGRIRPHTFTG | ||||||
Repeat | 411-432 | LRR 15 | ||||
Sequence: GLRRLFLKDNGLVGIEEQSLWG | ||||||
Repeat | 435-456 | LRR 16 | ||||
Sequence: ELLELDLTSNQLTHLPHRLFQG | ||||||
Repeat | 459-480 | LRR 17 | ||||
Sequence: KLEYLLLSRNRLAELPADALGP | ||||||
Repeat | 483-504 | LRR 18 | ||||
Sequence: RAFWLDVSHNRLEALPNSLLAP | ||||||
Repeat | 507-528 | LRR 19 | ||||
Sequence: RLRYLSLRNNSLRTFTPQPPGL | ||||||
Domain | 536-605 | LRRCT | ||||
Sequence: NPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P35858-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length605
- Mass (Da)66,035
- Last updated1994-06-01 v1
- ChecksumF6562A23CBE918F6
P35858-2
- Name2
- Differences from canonical
- 5-5: K → KAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H3BSX8 | H3BSX8_HUMAN | IGFALS | 131 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_044605 | 5 | in isoform 2 | |||
Sequence: K → KAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPA | ||||||
Sequence conflict | 10 | in Ref. 3; BAG64250 | ||||
Sequence: L → P |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M86826 EMBL· GenBank· DDBJ | AAA36047.1 EMBL· GenBank· DDBJ | mRNA | ||
AF192554 EMBL· GenBank· DDBJ | AAF06774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK303146 EMBL· GenBank· DDBJ | BAG64250.1 EMBL· GenBank· DDBJ | mRNA | ||
AC012180 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL031724 EMBL· GenBank· DDBJ | CAC36078.1 EMBL· GenBank· DDBJ | Genomic DNA |