P35754 · GLRX1_HUMAN

  • Protein
    Glutaredoxin-1
  • Gene
    GLRX
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentnucleus
Molecular Functionglutathione disulfide oxidoreductase activity
Molecular Functionsodium channel regulator activity
Biological Processnucleobase-containing small molecule interconversion
Biological Processpositive regulation of membrane potential

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutaredoxin-1
  • Alternative names
    • Thioltransferase-1 (TTase-1)

Gene names

    • Name
      GLRX
    • Synonyms
      GRX

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P35754
  • Secondary accessions
    • B2R4L2
    • Q3KQS1
    • Q6ICT1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04918947in dbSNP:rs4767

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 134 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, disulfide bond, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
Modified residue2UniProtN-acetylalanine
ChainPRO_00001416002-106UniProtGlutaredoxin-1
Modified residue9UniProtN6-succinyllysine
Disulfide bond23↔26UniProtRedox-active
Modified residue (large scale data)34PRIDEPhosphoserine
Disulfide bond79↔83UniProt

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P35754TRIM62 Q9BVG35EBI-3905236, EBI-6929619

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-106Glutaredoxin

Sequence similarities

Belongs to the glutaredoxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    106
  • Mass (Da)
    11,776
  • Last updated
    2007-01-23 v2
  • Checksum
    BB86FED55967EBE2
MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict96in Ref. 1; BAA04769

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D21238
EMBL· GenBank· DDBJ
BAA04769.1
EMBL· GenBank· DDBJ
mRNA
X76648
EMBL· GenBank· DDBJ
CAA54094.1
EMBL· GenBank· DDBJ
mRNA
AF069668
EMBL· GenBank· DDBJ
AAC35798.1
EMBL· GenBank· DDBJ
mRNA
AF115105
EMBL· GenBank· DDBJ
AAC98318.1
EMBL· GenBank· DDBJ
Genomic DNA
AF115104
EMBL· GenBank· DDBJ
AAC98318.1
EMBL· GenBank· DDBJ
Genomic DNA
AF162769
EMBL· GenBank· DDBJ
AAD43353.1
EMBL· GenBank· DDBJ
mRNA
BT006689
EMBL· GenBank· DDBJ
AAP35335.1
EMBL· GenBank· DDBJ
mRNA
CR450312
EMBL· GenBank· DDBJ
CAG29308.1
EMBL· GenBank· DDBJ
mRNA
CR542165
EMBL· GenBank· DDBJ
CAG46962.1
EMBL· GenBank· DDBJ
mRNA
AK311868
EMBL· GenBank· DDBJ
BAG34809.1
EMBL· GenBank· DDBJ
mRNA
DQ026062
EMBL· GenBank· DDBJ
AAY29058.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471084
EMBL· GenBank· DDBJ
EAW96056.1
EMBL· GenBank· DDBJ
Genomic DNA
BC005304
EMBL· GenBank· DDBJ
AAH05304.1
EMBL· GenBank· DDBJ
mRNA
BC010965
EMBL· GenBank· DDBJ
AAH10965.1
EMBL· GenBank· DDBJ
mRNA
BC106075
EMBL· GenBank· DDBJ
AAI06076.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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