P35631 · AP1_ARATH
- ProteinFloral homeotic protein APETALA 1
- GeneAP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids256 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor that promotes early floral meristem identity in synergy with LEAFY. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Is indispensable for normal development of sepals and petals in flowers. Positively regulates the B class homeotic proteins APETALA3 and PISTILLATA with the cooperation of LEAFY and UFO. Interacts with SEPALLATA3 or AP3/PI heterodimer to form complexes that could be involved in genes regulation during floral meristem development. Positively regulates AGAMOUS in cooperation with LEAFY. Displays a redundant function with CAULIFLOWER in the up-regulation of LEAFY. Together with AGL24 and SVP, controls the identity of the floral meristem and regulates expression of class B, C and E genes. Represses flowering time genes AGL24, SVP and SOC1 in emerging floral meristems.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | cell differentiation | |
Biological Process | floral meristem determinacy | |
Biological Process | flower development | |
Biological Process | meristem structural organization | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameFloral homeotic protein APETALA 1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP35631
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Partial conversion of flowers into shoots and a disruption of sepal and petal development.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 85 | in strain: cv. Chi-1 | ||||
Sequence: S → P | ||||||
Natural variant | 93 | in strain: cv. Bla-1 | ||||
Sequence: M → T | ||||||
Natural variant | 99 | in strain: cv. Chi-1 | ||||
Sequence: K → R | ||||||
Natural variant | 100 | in strain: cv. Landsberg erecta | ||||
Sequence: A → T | ||||||
Natural variant | 120 | in strain: cv. Jl-1 | ||||
Sequence: M → V | ||||||
Natural variant | 125 | in strain: cv. Bla-1 | ||||
Sequence: L → P | ||||||
Natural variant | 166 | in strain: cv. Jl-1 | ||||
Sequence: S → G | ||||||
Natural variant | 212 | in strain: cv. Chi-1 | ||||
Sequence: L → P | ||||||
Natural variant | 233 | in strain: cv. Co-1 | ||||
Sequence: A → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000199451 | 1-256 | Floral homeotic protein APETALA 1 | |||
Sequence: MGRGRVQLKRIENKINRQVTFSKRRAGLLKKAHEISVLCDAEVALVVFSHKGKLFEYSTDSCMEKILERYERYSYAERQLIAPESDVNTNWSMEYNRLKAKIELLERNQRHYLGEDLQAMSPKELQNLEQQLDTALKHIRTRKNQLMYESINELQKKEKAIQEQNSMLSKQIKEREKILRAQQEQWDQQNQGHNMPPPLPPQQHQIQHPYMLSHQPSPFLNMGGLYQEDDPMAMRRNDLELTLEPVYNCNLGCFAA |
Proteomic databases
Expression
Tissue specificity
Expressed in young flower primordia, later becomes localized to sepals and petals.
Induction
Negatively regulated by TFL1 and by the C class floral homeotic protein AGAMOUS. Positively regulated by CAULIFLOWER.
Developmental stage
Expressed at an early stage of floral initiation.
Gene expression databases
Interaction
Subunit
Homodimer capable of binding to CArG-box sequences. Heterodimer with SEP3, AP1 and SVP. Binds AP3/PI to form a ternary complex. Interacts with the SEU-LUG corepressor complex when complexed to AGL24 or SVP. Interacts with AGL15 and AGL16 (PubMed:15805477, PubMed:16679456).
Interacts with TT16/AGL32 (PubMed:16080001).
Interacts with TT16/AGL32 (PubMed:16080001).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P35631 | AGL21 Q9SZJ6 | 4 | EBI-592003, EBI-621986 | |
BINARY | P35631 | AGL24 O82794 | 4 | EBI-592003, EBI-592083 | |
XENO | P35631 | AYWB_224 Q2NJQ2 | 4 | EBI-592003, EBI-16100490 | |
BINARY | P35631 | SEP1 P29382 | 4 | EBI-592003, EBI-632935 | |
BINARY | P35631 | SEP3 O22456 | 4 | EBI-592003, EBI-592020 | |
BINARY | P35631 | SEU Q8W234 | 2 | EBI-592003, EBI-1771131 | |
BINARY | P35631 | SOC1 O64645 | 5 | EBI-592003, EBI-592041 | |
BINARY | P35631 | SVP Q9FVC1 | 5 | EBI-592003, EBI-592058 | |
BINARY | P35631 | TCP14 Q93Z00 | 3 | EBI-592003, EBI-4424563 | |
BINARY | P35631 | TCP15 Q9C9L2 | 3 | EBI-592003, EBI-4426144 | |
BINARY | P35631 | TCP4 Q8LPR5 | 3 | EBI-592003, EBI-15192325 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-61 | MADS-box | ||||
Sequence: MGRGRVQLKRIENKINRQVTFSKRRAGLLKKAHEISVLCDAEVALVVFSHKGKLFEYSTDS | ||||||
Domain | 88-178 | K-box | ||||
Sequence: NTNWSMEYNRLKAKIELLERNQRHYLGEDLQAMSPKELQNLEQQLDTALKHIRTRKNQLMYESINELQKKEKAIQEQNSMLSKQIKEREKI | ||||||
Coiled coil | 88-185 | |||||
Sequence: NTNWSMEYNRLKAKIELLERNQRHYLGEDLQAMSPKELQNLEQQLDTALKHIRTRKNQLMYESINELQKKEKAIQEQNSMLSKQIKEREKILRAQQEQ |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length256
- Mass (Da)30,182
- Last updated2002-06-20 v2
- Checksum01E26DE18CE3478C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8AMJ8 | A0A1P8AMJ8_ARATH | AP1 | 234 | ||
A0A1P8AML8 | A0A1P8AML8_ARATH | AP1 | 194 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 139 | in Ref. 5; BAD43696 | ||||
Sequence: I → M | ||||||
Sequence conflict | 184 | in Ref. 7; AAM28458 | ||||
Sequence: E → G | ||||||
Sequence conflict | 189 | in Ref. 6; AAM65504 | ||||
Sequence: Q → H | ||||||
Sequence conflict | 236 | in Ref. 1; CAA78909 | ||||
Sequence: Missing |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z16421 EMBL· GenBank· DDBJ | CAA78909.1 EMBL· GenBank· DDBJ | mRNA | ||
AC008262 EMBL· GenBank· DDBJ | AAF27070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE34887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT004113 EMBL· GenBank· DDBJ | AAO42136.1 EMBL· GenBank· DDBJ | mRNA | ||
BT004951 EMBL· GenBank· DDBJ | AAO50484.1 EMBL· GenBank· DDBJ | mRNA | ||
AK175933 EMBL· GenBank· DDBJ | BAD43696.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087956 EMBL· GenBank· DDBJ | AAM65504.1 EMBL· GenBank· DDBJ | mRNA | ||
AF466771 EMBL· GenBank· DDBJ | AAM28447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466772 EMBL· GenBank· DDBJ | AAM28448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466773 EMBL· GenBank· DDBJ | AAM28449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466774 EMBL· GenBank· DDBJ | AAM28450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466775 EMBL· GenBank· DDBJ | AAM28451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466776 EMBL· GenBank· DDBJ | AAM28452.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466777 EMBL· GenBank· DDBJ | AAM28453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466778 EMBL· GenBank· DDBJ | AAM28454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466779 EMBL· GenBank· DDBJ | AAM28455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466780 EMBL· GenBank· DDBJ | AAM28456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466781 EMBL· GenBank· DDBJ | AAM28457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466782 EMBL· GenBank· DDBJ | AAM28458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466783 EMBL· GenBank· DDBJ | AAM28459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466784 EMBL· GenBank· DDBJ | AAM28460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF466785 EMBL· GenBank· DDBJ | AAM28461.1 EMBL· GenBank· DDBJ | Genomic DNA |