P35383 · P2RY2_MOUSE
- ProteinP2Y purinoceptor 2
- GeneP2ry2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids373 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled purinergic nucleotide receptor activity | |
Biological Process | blood vessel diameter maintenance | |
Biological Process | establishment of localization in cell | |
Biological Process | mucus secretion | |
Biological Process | phospholipase C-activating G protein-coupled receptor signaling pathway | |
Biological Process | positive regulation of mucus secretion |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameP2Y purinoceptor 2
- Short namesP2Y2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP35383
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-32 | Extracellular | |||
Transmembrane | 33-59 | Helical; Name=1 | |||
Topological domain | 60-70 | Cytoplasmic | |||
Transmembrane | 71-93 | Helical; Name=2 | |||
Topological domain | 94-110 | Extracellular | |||
Transmembrane | 111-129 | Helical; Name=3 | |||
Topological domain | 130-152 | Cytoplasmic | |||
Transmembrane | 153-172 | Helical; Name=4 | |||
Topological domain | 173-194 | Extracellular | |||
Transmembrane | 195-220 | Helical; Name=5 | |||
Topological domain | 221-246 | Cytoplasmic | |||
Transmembrane | 247-269 | Helical; Name=6 | |||
Topological domain | 270-287 | Extracellular | |||
Transmembrane | 288-309 | Helical; Name=7 | |||
Topological domain | 310-373 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 107 | No effect on receptor activation. | |||
Mutagenesis | 110 | No effect on receptor activation. | |||
Mutagenesis | 262 | Decrease in receptor activation. | |||
Mutagenesis | 265 | Decrease in receptor activation. | |||
Mutagenesis | 289 | No effect on receptor activation. | |||
Mutagenesis | 292 | Decrease in receptor activation. | |||
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000070015 | 1-373 | UniProt | P2Y purinoceptor 2 | ||
Glycosylation | 9 | UniProt | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 13 | UniProt | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 106↔183 | UniProt | ||||
Modified residue (large scale data) | 327 | PTMeXchange | Phosphothreonine | |||
Modified residue (large scale data) | 329 | PTMeXchange | Phosphoserine | |||
Modified residue (large scale data) | 350 | PTMeXchange | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Spleen, testis, kidney, liver, lung, heart and brain.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 318-373 | Disordered | |||
Compositional bias | 332-344 | Basic residues | |||
Compositional bias | 345-360 | Basic and acidic residues | |||
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length373
- Mass (Da)42,175
- Last updated1994-06-01 v1
- MD5 Checksum6074F7E12FA283CFF108E099F5AF5B2D
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0R4J289 | A0A0R4J289_MOUSE | P2ry2 | 373 | ||
A0A140LIR2 | A0A140LIR2_MOUSE | P2ry2 | 21 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 17 | in Ref. 2; AAB50735 | |||
Sequence conflict | 120 | in Ref. 2; AAB50735 | |||
Sequence conflict | 125 | in Ref. 2; AAB50735 | |||
Sequence conflict | 196 | in Ref. 2; AAB50735 | |||
Sequence conflict | 263 | in Ref. 3; BAB23746/BAB30719 | |||
Compositional bias | 332-344 | Basic residues | |||
Compositional bias | 345-360 | Basic and acidic residues | |||
Sequence conflict | 355 | in Ref. 2; AAB50735 | |||
Sequence conflict | 369-371 | in Ref. 2; AAB50735 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L14751 EMBL· GenBank· DDBJ | AAA39871.1 EMBL· GenBank· DDBJ | mRNA | ||
S83099 EMBL· GenBank· DDBJ | AAB50735.1 EMBL· GenBank· DDBJ | mRNA | ||
AK005013 EMBL· GenBank· DDBJ | BAB23746.1 EMBL· GenBank· DDBJ | mRNA | ||
AK017378 EMBL· GenBank· DDBJ | BAB30719.1 EMBL· GenBank· DDBJ | mRNA | ||
BC006613 EMBL· GenBank· DDBJ | AAH06613.1 EMBL· GenBank· DDBJ | mRNA |