P35383 · P2RY2_MOUSE

  • Protein
    P2Y purinoceptor 2
  • Gene
    P2ry2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled purinergic nucleotide receptor activity
Biological Processblood vessel diameter maintenance
Biological Processestablishment of localization in cell
Biological Processmucus secretion
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processpositive regulation of mucus secretion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    P2Y purinoceptor 2
  • Short names
    P2Y2
  • Alternative names
    • ATP receptor
    • P2U purinoceptor 1 (P2U1)
    • Purinergic receptor

Gene names

    • Name
      P2ry2
    • Synonyms
      P2ru1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P35383
  • Secondary accessions
    • O09031
    • Q9CPZ4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-32Extracellular
Transmembrane33-59Helical; Name=1
Topological domain60-70Cytoplasmic
Transmembrane71-93Helical; Name=2
Topological domain94-110Extracellular
Transmembrane111-129Helical; Name=3
Topological domain130-152Cytoplasmic
Transmembrane153-172Helical; Name=4
Topological domain173-194Extracellular
Transmembrane195-220Helical; Name=5
Topological domain221-246Cytoplasmic
Transmembrane247-269Helical; Name=6
Topological domain270-287Extracellular
Transmembrane288-309Helical; Name=7
Topological domain310-373Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis107No effect on receptor activation.
Mutagenesis110No effect on receptor activation.
Mutagenesis262Decrease in receptor activation.
Mutagenesis265Decrease in receptor activation.
Mutagenesis289No effect on receptor activation.
Mutagenesis292Decrease in receptor activation.

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue (large scale data).

Type
IDPosition(s)Source
Description
ChainPRO_00000700151-373UniProtP2Y purinoceptor 2
Glycosylation9UniProtN-linked (GlcNAc...) asparagine
Glycosylation13UniProtN-linked (GlcNAc...) asparagine
Disulfide bond106↔183UniProt
Modified residue (large scale data)327PTMeXchangePhosphothreonine
Modified residue (large scale data)329PTMeXchangePhosphoserine
Modified residue (large scale data)350PTMeXchangePhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Spleen, testis, kidney, liver, lung, heart and brain.

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region318-373Disordered
Compositional bias332-344Basic residues
Compositional bias345-360Basic and acidic residues

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    373
  • Mass (Da)
    42,175
  • Last updated
    1994-06-01 v1
  • MD5 Checksum
    6074F7E12FA283CFF108E099F5AF5B2D
MAADLEPWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSLRWGRARYARRVAAVVWVLVLACQAPVLYFVTTSVRGTRITCHDTSARELFSHFVAYSSVMLGLLFAVPFSVILVCYVLMARRLLKPAYGTTGGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTEPTPSPQARRKLGLHRPNRTVRKDLSVSSDDSRRTESTPAGSETKDIRL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4J289A0A0R4J289_MOUSEP2ry2373
A0A140LIR2A0A140LIR2_MOUSEP2ry221

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict17in Ref. 2; AAB50735
Sequence conflict120in Ref. 2; AAB50735
Sequence conflict125in Ref. 2; AAB50735
Sequence conflict196in Ref. 2; AAB50735
Sequence conflict263in Ref. 3; BAB23746/BAB30719
Compositional bias332-344Basic residues
Compositional bias345-360Basic and acidic residues
Sequence conflict355in Ref. 2; AAB50735
Sequence conflict369-371in Ref. 2; AAB50735

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L14751
EMBL· GenBank· DDBJ
AAA39871.1
EMBL· GenBank· DDBJ
mRNA
S83099
EMBL· GenBank· DDBJ
AAB50735.1
EMBL· GenBank· DDBJ
mRNA
AK005013
EMBL· GenBank· DDBJ
BAB23746.1
EMBL· GenBank· DDBJ
mRNA
AK017378
EMBL· GenBank· DDBJ
BAB30719.1
EMBL· GenBank· DDBJ
mRNA
BC006613
EMBL· GenBank· DDBJ
AAH06613.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help