P35241 · RADI_HUMAN
- ProteinRadixin
- GeneRDX
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids583 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Activity regulation
Features
Showing features for binding site.
GO annotations
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRadixin
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP35241
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Deafness, autosomal recessive, 24 (DFNB24)
- Note
- DescriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
- See alsoMIM:611022
Natural variants in DFNB24
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_036859 | 578 | D>N | in DFNB24; dbSNP:rs121918379 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_036857 | 328 | in dbSNP:rs17854427 | |||
Sequence: K → E | ||||||
Natural variant | VAR_036858 | 490 | in dbSNP:rs34471100 | |||
Sequence: D → N | ||||||
Natural variant | VAR_036859 | 578 | in DFNB24; dbSNP:rs121918379 | |||
Sequence: D → N |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 628 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000219421 | 1-583 | UniProt | Radixin | |||
Sequence: MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM | |||||||
Modified residue | 83 | UniProt | N6-succinyllysine | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 249 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 270 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 299 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 532 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 533 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 564 | UniProt | Phosphothreonine; by ROCK2 | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 564 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with NHERF1, NHERF2, LAYN, MME/NEP and ICAM2. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain). Interacts (via FERM domain) with SPN/CD43 cytoplasmic tail (By similarity).
Interacts with CD44 (By similarity).
Interacts with CLIC5; may work together in a complex which also includes EZR and MYO6 to stabilize linkages between the plasma membrane and subjacent actin cytoskeleton at the base of stereocilia (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P35241 | EZR P15311 | 10 | EBI-2514878, EBI-1056902 | |
BINARY | P35241 | ITGB2 P05107 | 2 | EBI-2514878, EBI-300173 | |
BINARY | P35241 | KIRREL3 Q8IZU9 | 5 | EBI-2514878, EBI-16427312 | |
XENO | P35241 | rep PRO_0000449630 P0DTD1 | 3 | EBI-2514878, EBI-25475888 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-295 | FERM | ||||
Sequence: INVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR | ||||||
Region | 310-330 | Disordered | ||||
Sequence: REEKHQKQLERAQLENEKKKR | ||||||
Compositional bias | 376-400 | Basic and acidic residues | ||||
Sequence: DQERKRAKEEAERLEKERRAAEEAK | ||||||
Region | 376-407 | Disordered | ||||
Sequence: DQERKRAKEEAERLEKERRAAEEAKSAIAKQA | ||||||
Region | 462-526 | Disordered | ||||
Sequence: ELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKK | ||||||
Compositional bias | 467-481 | Pro residues | ||||
Sequence: MSAPPPPPPPPVIPP | ||||||
Compositional bias | 482-496 | Basic and acidic residues | ||||
Sequence: TENEHDEHDENNAEA | ||||||
Compositional bias | 505-524 | Basic and acidic residues | ||||
Sequence: VMNHRSEEERVTETQKNERV |
Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
P35241-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length583
- Mass (Da)68,564
- Last updated1994-02-01 v1
- Checksum889687E1D675FFE7
P35241-2
- Name2
P35241-3
- Name3
P35241-4
- Name4
- Differences from canonical
- 1-156: MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQR → MLSWNLPFSPIQLANNFLTS
P35241-5
- Name5
- Differences from canonical
- 583-583: M → MWGPKLYALFQMRSCQSSIKQM
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Y7M3 | A0A2R8Y7M3_HUMAN | RDX | 534 | ||
A0A2R8Y5S7 | A0A2R8Y5S7_HUMAN | RDX | 590 | ||
A0A2R8Y5P0 | A0A2R8Y5P0_HUMAN | RDX | 115 | ||
A0A2R8Y4H6 | A0A2R8Y4H6_HUMAN | RDX | 152 | ||
E9PRS5 | E9PRS5_HUMAN | RDX | 44 | ||
E9PQ82 | E9PQ82_HUMAN | RDX | 116 | ||
E9PNV3 | E9PNV3_HUMAN | RDX | 148 | ||
E9PNP4 | E9PNP4_HUMAN | RDX | 52 | ||
E9PN07 | E9PN07_HUMAN | RDX | 50 | ||
E9PKN5 | E9PKN5_HUMAN | RDX | 51 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_047276 | 1-156 | in isoform 4 | |||
Sequence: MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQR → MLSWNLPFSPIQLANNFLTS | ||||||
Alternative sequence | VSP_045315 | 1-347 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_045316 | 33-64 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_045317 | 168-539 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 376-400 | Basic and acidic residues | ||||
Sequence: DQERKRAKEEAERLEKERRAAEEAK | ||||||
Sequence conflict | 435 | in Ref. 2; BAH14432 | ||||
Sequence: K → R | ||||||
Compositional bias | 467-481 | Pro residues | ||||
Sequence: MSAPPPPPPPPVIPP | ||||||
Compositional bias | 482-496 | Basic and acidic residues | ||||
Sequence: TENEHDEHDENNAEA | ||||||
Compositional bias | 505-524 | Basic and acidic residues | ||||
Sequence: VMNHRSEEERVTETQKNERV | ||||||
Alternative sequence | VSP_045318 | 583 | in isoform 2, isoform 3 and isoform 5 | |||
Sequence: M → MWGPKLYALFQMRSCQSSIKQM |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L02320 EMBL· GenBank· DDBJ | AAA36541.1 EMBL· GenBank· DDBJ | mRNA | ||
AK316061 EMBL· GenBank· DDBJ | BAH14432.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ916738 EMBL· GenBank· DDBJ | ABI34710.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ916739 EMBL· GenBank· DDBJ | ABI34711.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ916741 EMBL· GenBank· DDBJ | ABI34713.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ916742 EMBL· GenBank· DDBJ | ABI34714.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ916740 EMBL· GenBank· DDBJ | ABI34712.1 EMBL· GenBank· DDBJ | mRNA | ||
AP000901 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AP002788 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471065 EMBL· GenBank· DDBJ | EAW67129.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC047109 EMBL· GenBank· DDBJ | AAH47109.1 EMBL· GenBank· DDBJ | mRNA |