P35225 · IL13_HUMAN

  • Protein
    Interleukin-13
  • Gene
    IL13
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324).
Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327).
Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755).
Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity).
Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity).
Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787).
Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879).
Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864).

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functioninterleukin-13 receptor binding
Biological Processcellular response to cytokine stimulus
Biological Processcellular response to mechanical stimulus
Biological Processimmune response
Biological Processinflammatory response
Biological Processmacrophage activation
Biological Processmicroglial cell activation
Biological Processnegative regulation of complement-dependent cytotoxicity
Biological Processnegative regulation of endothelial cell apoptotic process
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of lung ciliated cell differentiation
Biological Processnegative regulation of transforming growth factor beta production
Biological Processpositive regulation of B cell proliferation
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of connective tissue growth factor production
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of immunoglobulin production
Biological Processpositive regulation of interleukin-10 production
Biological Processpositive regulation of lung goblet cell differentiation
Biological Processpositive regulation of macrophage activation
Biological Processpositive regulation of mast cell degranulation
Biological Processpositive regulation of pancreatic stellate cell proliferation
Biological Processpositive regulation of protein secretion
Biological Processpositive regulation of release of sequestered calcium ion into cytosol
Biological Processpositive regulation of smooth muscle cell proliferation
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processregulation of proton transport
Biological Processresponse to ethanol
Biological Processresponse to lipopolysaccharide
Biological Processresponse to nicotine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-13
  • Short names
    IL-13

Gene names

    • Name
      IL13
    • Synonyms
      NC30

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P35225
  • Secondary accessions
    • O43644
    • Q4VB52
    • Q9UDC7

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Allergic rhinitis (ALRH)

  • Note
    • Disease susceptibility may be associated with variants affecting the gene represented in this entry
  • Description
    A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
  • See also
    MIM:607154

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_010037144probable protective factor against ALRH; may be associated with decreased risk for asthma development; at homozygosity may be associated with lower levels of serum total IgE in some allergic rhinitis patients; dbSNP:rs20541

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 154 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000001554725-146Interleukin-13
Glycosylation52N-linked (GlcNAc...) asparagine
Disulfide bond62↔90
Glycosylation63N-linked (GlcNAc...) asparagine
Glycosylation71N-linked (GlcNAc...) asparagine
Disulfide bond78↔104
Glycosylation86N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with IL13RA2.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P35225IL13RA1 P785527EBI-1647828, EBI-1391535
BINARY P35225IL13RA2 Q146279EBI-1647828, EBI-4320063
View interactors in UniProtKB
View CPX-844 in Complex Portal

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the IL-4/IL-13 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    146
  • Mass (Da)
    15,788
  • Last updated
    2024-01-24 v3
  • Checksum
    BE2D441CF913D129
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGQFN

Sequence caution

The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict1in Ref. 2; CAA48824
Sequence conflict26in Ref. 9; no nucleotide entry
Sequence conflict32in Ref. 9; no nucleotide entry
Sequence conflict51in Ref. 9; no nucleotide entry
Sequence conflict56in Ref. 9; no nucleotide entry
Sequence conflict59in Ref. 3; AAA83738
Sequence conflict101in Ref. 8; AAC03535
Sequence conflict112in Ref. 3; AAA83738

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X69079
EMBL· GenBank· DDBJ
CAA48823.1
EMBL· GenBank· DDBJ
mRNA
X69079
EMBL· GenBank· DDBJ
CAA48824.1
EMBL· GenBank· DDBJ
mRNA Different initiation
L06801
EMBL· GenBank· DDBJ
AAA36107.1
EMBL· GenBank· DDBJ
mRNA Different initiation
U10307
EMBL· GenBank· DDBJ
AAA83738.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
U31120
EMBL· GenBank· DDBJ
AAB01681.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AF377331
EMBL· GenBank· DDBJ
AAK53823.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AC004039
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC096139
EMBL· GenBank· DDBJ
AAH96139.1
EMBL· GenBank· DDBJ
mRNA
AF043334
EMBL· GenBank· DDBJ
AAC03535.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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