P35192 · MAC1_YEAST
- ProteinMetal-binding activator 1
- GeneMAC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids417 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulatory protein involved in Cu/Fe utilization and stress resistance. Involved in basal level transcription of FRE1 and H2O2-induced transcription of CTT1. Regulates the transcription of CTR1 and CTR3 via the copper ion responsive elements in their promoters. Required for degradation of CTR1.
Miscellaneous
Present with 14800 molecules/cell in log phase SD medium.
Features
Showing features for dna binding, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 1-40 | Copper-fist | |||
Binding site | 11 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 14 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 23 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 25 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | cis-regulatory region sequence-specific DNA binding | |
Molecular Function | copper ion binding | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | intracellular copper ion homeostasis | |
Biological Process | intracellular iron ion homeostasis | |
Biological Process | positive regulation of protein catabolic process | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMetal-binding activator 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP35192
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 279 | Gain of function. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000194928 | 1-417 | Metal-binding activator 1 | ||
Modified residue | 143 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 128-198 | Disordered | |||
Compositional bias | 150-174 | Basic and acidic residues | |||
Compositional bias | 175-191 | Polar residues | |||
Region | 216-242 | Disordered | |||
Repeat | 264-279 | 1 | |||
Region | 264-337 | 2 X 16 AA repeat of C-X-C-X4-C-X-C-X-X-C-X-X-H | |||
Repeat | 322-337 | 2 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length417
- Mass (Da)46,516
- Last updated1996-10-01 v2
- MD5 ChecksumE40175EFCE58E513D0D00CCB847CFD4B
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 150-174 | Basic and acidic residues | |||
Compositional bias | 175-191 | Polar residues | |||
Sequence conflict | 198 | in Ref. 1; CAA52645 | |||
Sequence conflict | 380 | in Ref. 4; AAT92953 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X74551 EMBL· GenBank· DDBJ | CAA52645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49211 EMBL· GenBank· DDBJ | CAA89124.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY692934 EMBL· GenBank· DDBJ | AAT92953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006946 EMBL· GenBank· DDBJ | DAA09919.1 EMBL· GenBank· DDBJ | Genomic DNA |