P35192 · MAC1_YEAST

Function

function

Regulatory protein involved in Cu/Fe utilization and stress resistance. Involved in basal level transcription of FRE1 and H2O2-induced transcription of CTT1. Regulates the transcription of CTR1 and CTR3 via the copper ion responsive elements in their promoters. Required for degradation of CTR1.

Miscellaneous

Present with 14800 molecules/cell in log phase SD medium.

Features

Showing features for dna binding, binding site.

141750100150200250300350400
Type
IDPosition(s)Description
DNA binding1-40Copper-fist
Binding site11Zn2+ (UniProtKB | ChEBI)
Binding site14Zn2+ (UniProtKB | ChEBI)
Binding site23Zn2+ (UniProtKB | ChEBI)
Binding site25Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular Functioncopper ion binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processintracellular copper ion homeostasis
Biological Processintracellular iron ion homeostasis
Biological Processpositive regulation of protein catabolic process
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Metal-binding activator 1

Gene names

    • Name
      MAC1
    • Synonyms
      CUA1
    • ORF names
      YM9711.11C
    • Ordered locus names
      YMR021C

Organism names

Accessions

  • Primary accession
    P35192
  • Secondary accessions
    • D6VZJ5
    • E9P8Z5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis279Gain of function.

Variants

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The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

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PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001949281-417Metal-binding activator 1
Modified residue143Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

Type
IDPosition(s)Description
Region128-198Disordered
Compositional bias150-174Basic and acidic residues
Compositional bias175-191Polar residues
Region216-242Disordered
Repeat264-2791
Region264-3372 X 16 AA repeat of C-X-C-X4-C-X-C-X-X-C-X-X-H
Repeat322-3372

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    46,516
  • Last updated
    1996-10-01 v2
  • MD5 Checksum
    E40175EFCE58E513D0D00CCB847CFD4B
MIIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPSPMAIRDAILVDSTSQSTEYENGAQIEGDCCSAMNQQPILFVRASAVRKARMINGKLHILMEEGFTAHEPKDISTFTDDGNKYITETEFLRKHSPKAPATGTISPDSTKSSSSSEKKERSRLQQEPIRHFSNCCKKDKSQNPASNGKTNKAPSDDIFTPYGSLESTSAFNDILQENYNSSVPGAHDSSETLTPQSTTTIAAPHSSDVASKVEVLTHKGIFLSTQCSCEDESCPCVNCLIHRSEEELNSYIQQSGVPLTNIGEAQITDKMMDYLDDCKCTDKECICPPDNCTCDGCFSHSTNIIPFEKFFFYGILNARLTRKTQIKFKGKLVPSKYWWDFLKLQVPLMTDAQLELLDIHAWFQKLVSNYAPHLSDATTS

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias150-174Basic and acidic residues
Compositional bias175-191Polar residues
Sequence conflict198in Ref. 1; CAA52645
Sequence conflict380in Ref. 4; AAT92953

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X74551
EMBL· GenBank· DDBJ
CAA52645.1
EMBL· GenBank· DDBJ
Genomic DNA
Z49211
EMBL· GenBank· DDBJ
CAA89124.1
EMBL· GenBank· DDBJ
Genomic DNA
AY692934
EMBL· GenBank· DDBJ
AAT92953.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006946
EMBL· GenBank· DDBJ
DAA09919.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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