P35128 · UBE2N_DROME
- ProteinUbiquitin-conjugating enzyme E2 N
- Geneben
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids151 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the covalent attachment of ubiquitin to other proteins.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 87 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin-conjugating enzyme E2 N
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP35128
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Mutants in this gene exhibit several, largely neuronal defects including lesions affecting the neuronal connectivity of the giant fiber with the 'jumping muscle', and the axons of photoreceptor cells R7 and R8 fail to make the proper right-angle turn into the medulla (hence the term 'bendless').
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082521 | 1-151 | Ubiquitin-conjugating enzyme E2 N | |||
Sequence: MSSLPRRIIKETQRLMQEPVPGINAIPDENNARYFHVIVTGPNDSPFEGGVFKLELFLPEDYPMSAPKVRFITKIYHPNIDRLGRICLDVLKDKWSPALQIRTILLSIQALLSAPNPDDPLANDVAELWKVNEAEAIRNAREWTQKYAVED |
Proteomic databases
Expression
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P35128 | Uev1A Q9VRL1 | 4 | EBI-101550, EBI-192329 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-149 | UBC core | ||||
Sequence: SLPRRIIKETQRLMQEPVPGINAIPDENNARYFHVIVTGPNDSPFEGGVFKLELFLPEDYPMSAPKVRFITKIYHPNIDRLGRICLDVLKDKWSPALQIRTILLSIQALLSAPNPDDPLANDVAELWKVNEAEAIRNAREWTQKYAV |
Sequence similarities
Belongs to the ubiquitin-conjugating enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length151
- Mass (Da)17,236
- Last updated1994-02-01 v1
- Checksum1D096E72A7AEA420
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E1JJN1 | E1JJN1_DROME | ben | 151 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L20126 EMBL· GenBank· DDBJ | AAA28392.1 EMBL· GenBank· DDBJ | mRNA | ||
S70118 EMBL· GenBank· DDBJ | AAB30753.1 EMBL· GenBank· DDBJ | mRNA | ||
EU217226 EMBL· GenBank· DDBJ | ABW92183.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217227 EMBL· GenBank· DDBJ | ABW92184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217228 EMBL· GenBank· DDBJ | ABW92185.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217229 EMBL· GenBank· DDBJ | ABW92186.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217230 EMBL· GenBank· DDBJ | ABW92187.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217231 EMBL· GenBank· DDBJ | ABW92188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217232 EMBL· GenBank· DDBJ | ABW92189.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217233 EMBL· GenBank· DDBJ | ABW92190.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217234 EMBL· GenBank· DDBJ | ABW92191.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217235 EMBL· GenBank· DDBJ | ABW92192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217236 EMBL· GenBank· DDBJ | ABW92193.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU217237 EMBL· GenBank· DDBJ | ABW92194.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF48338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY069527 EMBL· GenBank· DDBJ | AAL39672.1 EMBL· GenBank· DDBJ | mRNA |