P35001 · NEUM_CHICK

Function

function

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentfilopodium membrane
Cellular Componentgrowth cone membrane
Cellular Componentneuron projection terminus
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density
Cellular Componentsynaptic membrane
Molecular Functioncalmodulin binding
Molecular Functionlysophosphatidic acid binding
Molecular Functionphosphatidylinositol phosphate binding
Molecular Functionphosphatidylserine binding
Biological Processaxon choice point recognition
Biological Processaxon regeneration
Biological Processregulation of growth
Biological Processtissue regeneration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuromodulin
  • Alternative names
    • Axonal membrane protein GAP-43
    • Growth-associated protein 43

Gene names

    • Name
      GAP43

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    P35001

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell projection, growth cone membrane
; Peripheral membrane protein
Synapse
Cell projection, filopodium membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain, lipidation.

TypeIDPosition(s)Description
ChainPRO_00001596001-246Neuromodulin
Lipidation3S-palmitoyl cysteine
Lipidation4S-palmitoyl cysteine

Post-translational modification

Palmitoylated (PubMed:9813098).
Palmitoylation is essential for plasma membrane association (PubMed:9813098).

Keywords

Expression

Tissue specificity

Expressed in neurons.

Developmental stage

First expressed in the body and head at embryonic stage 3 dpc (PubMed:2153895).
Expressed in the mid-thoracic region of embryos and also in the spinal cord, dorsal root and sympathetic ganglia at embryonic stage 10 dpc (PubMed:2153895).
Highly expressed in the brain at embryonic stage 13 dpc (PubMed:2153895).
Expressed at low levels in the gut at embryonic stage 16 dpc (PubMed:2153895).
Not expressed in heart, skeletal muscle or liver at embryonic stage 16 dpc (PubMed:2153895).

Interaction

Subunit

Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-246Disordered
Compositional bias8-37Basic and acidic residues
Domain32-61IQ
Compositional bias52-79Basic and acidic residues
Compositional bias164-178Basic and acidic residues
Compositional bias181-210Polar residues
Compositional bias211-246Basic and acidic residues

Sequence similarities

Belongs to the neuromodulin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    246
  • Mass (Da)
    25,631
  • Last updated
    2022-08-03 v2
  • Checksum
    6F9330F121126F01
MLCCMRRTKQVEKNEDGDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKADAPASESEAADKKDEGPAGGAAENKESEASAATEASAADSAQLDEGSKDSSVPAEEKKGNGAADTGSEQPAPQAATPAASSEEKPAAAAETESATKASTDNSPSLKADEAQDKEEPKQADVPAADTTATTTPAAEDATAKATAQPQMETVESSQTEEKTDAVEETKPTESAQQEEVKEEESKADQENA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias8-37Basic and acidic residues
Compositional bias52-79Basic and acidic residues
Compositional bias164-178Basic and acidic residues
Compositional bias181-210Polar residues
Compositional bias211-246Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp