P34996 · P2RY1_CHICK
- ProteinP2Y purinoceptor 1
- GeneP2RY1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids362 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for extracellular adenine nucleotides such as ADP (PubMed:8508924).
In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).
In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | A1 adenosine receptor binding | |
Molecular Function | ATP binding | |
Molecular Function | G protein-coupled ADP receptor activity | |
Molecular Function | G protein-coupled ATP receptor activity | |
Biological Process | cellular response to purine-containing compound | |
Biological Process | phospholipase C-activating G protein-coupled receptor signaling pathway | |
Biological Process | platelet activation | |
Biological Process | regulation of cell shape | |
Biological Process | relaxation of muscle |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameP2Y purinoceptor 1
- Short namesP2Y1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionP34996
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-40 | Extracellular | ||||
Sequence: MTEALISAALNGTQPELLAGGWAAGNATTKCSLTKTGFQF | ||||||
Transmembrane | 41-63 | Helical; Name=1 | ||||
Sequence: YYLPTVYILVFITGFLGNSVAIW | ||||||
Topological domain | 64-76 | Cytoplasmic | ||||
Sequence: MFVFHMRPWSGIS | ||||||
Transmembrane | 77-98 | Helical; Name=2 | ||||
Sequence: VYMFNLALADFLYVLTLPALIF | ||||||
Topological domain | 99-114 | Extracellular | ||||
Sequence: YYFNKTDWIFGDVMCK | ||||||
Transmembrane | 115-136 | Helical; Name=3 | ||||
Sequence: LQRFIFHVNLYGSILFLTCISV | ||||||
Topological domain | 137-155 | Cytoplasmic | ||||
Sequence: HRYTGVVHPLKSLGRLKKK | ||||||
Transmembrane | 156-177 | Helical; Name=4 | ||||
Sequence: NAVYVSSLVWALVVAVIAPILF | ||||||
Topological domain | 178-203 | Extracellular | ||||
Sequence: YSGTGVRRNKTITCYDTTADEYLRSY | ||||||
Transmembrane | 204-226 | Helical; Name=5 | ||||
Sequence: FVYSMCTTVFMFCIPFIVILGCY | ||||||
Topological domain | 227-249 | Cytoplasmic | ||||
Sequence: GLIVKALIYKDLDNSPLRRKSIY | ||||||
Transmembrane | 250-273 | Helical; Name=6 | ||||
Sequence: LVIIVLTVFAVSYLPFHVMKTLNL | ||||||
Topological domain | 274-292 | Extracellular | ||||
Sequence: RARLDFQTPQMCAFNDKVY | ||||||
Transmembrane | 293-314 | Helical; Name=7 | ||||
Sequence: ATYQVTRGLASLNSCVDPILYF | ||||||
Topological domain | 315-362 | Cytoplasmic | ||||
Sequence: LAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070009 | 1-362 | P2Y purinoceptor 1 | |||
Sequence: MTEALISAALNGTQPELLAGGWAAGNATTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL | ||||||
Glycosylation | 11 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 26 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 31↔285 | |||||
Sequence: CSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMC | ||||||
Glycosylation | 102 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 113↔191 | |||||
Sequence: CKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITC | ||||||
Glycosylation | 186 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Brain, spinal cord, gastrointestinal tract, spleen and leg muscle. Is not detected in the heart, liver, stomach, lung and kidney.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length362
- Mass (Da)41,194
- Last updated1994-02-01 v1
- ChecksumA806C88FB9514761
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V0X147 | A0A8V0X147_CHICK | P2RY1 | 370 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X73268 EMBL· GenBank· DDBJ | CAA51716.1 EMBL· GenBank· DDBJ | mRNA |