P34975 · OPRK_RAT

  • Protein
    Kappa-type opioid receptor
  • Gene
    Oprk1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon terminus
Cellular Componentcytosol
Cellular Componentdendrite
Cellular Componentmembrane
Cellular Componentmitochondrion
Cellular Componentneuron projection
Cellular Componentneuronal cell body
Cellular Componentnucleoplasm
Cellular Componentperikaryon
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentpresynaptic membrane
Cellular Componentsarcolemma
Cellular Componentsarcoplasmic reticulum
Cellular Componentsynaptic vesicle membrane
Cellular ComponentT-tubule
Molecular Functiondynorphin receptor activity
Molecular FunctionG protein-coupled opioid receptor activity
Molecular Functionneuropeptide binding
Molecular Functionreceptor serine/threonine kinase binding
Biological Processadenylate cyclase-inhibiting opioid receptor signaling pathway
Biological Processbehavioral response to cocaine
Biological Processcellular response to glucose stimulus
Biological Processcellular response to lipopolysaccharide
Biological Processconditioned place preference
Biological Processdefense response to virus
Biological Processeating behavior
Biological Processestrous cycle
Biological ProcessG protein-coupled opioid receptor signaling pathway
Biological Processimmune response
Biological Processlocomotory behavior
Biological Processmaternal behavior
Biological Processnegative regulation of luteinizing hormone secretion
Biological Processneuropeptide signaling pathway
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processpositive regulation of dopamine secretion
Biological Processpositive regulation of eating behavior
Biological Processpositive regulation of p38MAPK cascade
Biological Processpositive regulation of potassium ion transmembrane transport
Biological Processregulation of saliva secretion
Biological Processresponse to acrylamide
Biological Processresponse to cocaine
Biological Processresponse to estrogen
Biological Processresponse to ethanol
Biological Processresponse to insulin
Biological Processresponse to nicotine
Biological Processsensory perception of pain
Biological Processsensory perception of temperature stimulus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kappa-type opioid receptor
  • Short names
    K-OR-1; KOR-1

Gene names

    • Name
      Oprk1
    • Synonyms
      Ror-d

Organism names

  • Taxonomic identifier
  • Strains
    • Sprague-Dawley
    • Wistar
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P34975

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-57Extracellular
Transmembrane58-85Helical; Name=1
Topological domain86-95Cytoplasmic
Transmembrane96-119Helical; Name=2
Topological domain120-132Extracellular
Transmembrane133-154Helical; Name=3
Topological domain155-173Cytoplasmic
Transmembrane174-196Helical; Name=4
Topological domain197-222Extracellular
Transmembrane223-247Helical; Name=5
Topological domain248-274Cytoplasmic
Transmembrane275-296Helical; Name=6
Topological domain297-311Extracellular
Transmembrane312-333Helical; Name=7
Topological domain334-380Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, lipidation.

TypeIDPosition(s)Description
ChainPRO_00000699691-380Kappa-type opioid receptor
Glycosylation25N-linked (GlcNAc...) asparagine
Glycosylation39N-linked (GlcNAc...) asparagine
Disulfide bond131↔210
Lipidation345S-palmitoyl cysteine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with NHERF1. Interacts with GABARAPL1 (By similarity).

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,688
  • Last updated
    1994-02-01 v1
  • Checksum
    107FEEDB09886F92
MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict42in Ref. 2; BAA04109
Sequence conflict345in Ref. 3; AAA41496

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L22001
EMBL· GenBank· DDBJ
AAA41495.1
EMBL· GenBank· DDBJ
mRNA
D16829
EMBL· GenBank· DDBJ
BAA04109.1
EMBL· GenBank· DDBJ
mRNA
L22536
EMBL· GenBank· DDBJ
AAA41496.1
EMBL· GenBank· DDBJ
mRNA
U00442
EMBL· GenBank· DDBJ
AAA18261.1
EMBL· GenBank· DDBJ
mRNA
D16534
EMBL· GenBank· DDBJ
BAA03971.1
EMBL· GenBank· DDBJ
mRNA
U17995
EMBL· GenBank· DDBJ
AAC53249.1
EMBL· GenBank· DDBJ
Genomic DNA
U17993
EMBL· GenBank· DDBJ
AAC53249.1
EMBL· GenBank· DDBJ
Genomic DNA
U17994
EMBL· GenBank· DDBJ
AAC53249.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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