P34975 · OPRK_RAT
- ProteinKappa-type opioid receptor
- GeneOprk1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKappa-type opioid receptor
- Short namesK-OR-1; KOR-1
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP34975
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-57 | Extracellular | ||||
Sequence: MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPA | ||||||
Transmembrane | 58-85 | Helical; Name=1 | ||||
Sequence: IPVIITAVYSVVFVVGLVGNSLVMFVII | ||||||
Topological domain | 86-95 | Cytoplasmic | ||||
Sequence: RYTKMKTATN | ||||||
Transmembrane | 96-119 | Helical; Name=2 | ||||
Sequence: IYIFNLALADALVTTTMPFQSAVY | ||||||
Topological domain | 120-132 | Extracellular | ||||
Sequence: LMNSWPFGDVLCK | ||||||
Transmembrane | 133-154 | Helical; Name=3 | ||||
Sequence: IVISIDYYNMFTSIFTLTMMSV | ||||||
Topological domain | 155-173 | Cytoplasmic | ||||
Sequence: DRYIAVCHPVKALDFRTPL | ||||||
Transmembrane | 174-196 | Helical; Name=4 | ||||
Sequence: KAKIINICIWLLASSVGISAIVL | ||||||
Topological domain | 197-222 | Extracellular | ||||
Sequence: GGTKVREDVDVIECSLQFPDDEYSWW | ||||||
Transmembrane | 223-247 | Helical; Name=5 | ||||
Sequence: DLFMKICVFVFAFVIPVLIIIVCYT | ||||||
Topological domain | 248-274 | Cytoplasmic | ||||
Sequence: LMILRLKSVRLLSGSREKDRNLRRITK | ||||||
Transmembrane | 275-296 | Helical; Name=6 | ||||
Sequence: LVLVVVAVFIICWTPIHIFILV | ||||||
Topological domain | 297-311 | Extracellular | ||||
Sequence: EALGSTSHSTAVLSS | ||||||
Transmembrane | 312-333 | Helical; Name=7 | ||||
Sequence: YYFCIALGYTNSSLNPVLYAFL | ||||||
Topological domain | 334-380 | Cytoplasmic | ||||
Sequence: DENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV |
Keywords
- Cellular component
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069969 | 1-380 | Kappa-type opioid receptor | |||
Sequence: MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV | ||||||
Glycosylation | 25 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 39 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 131↔210 | |||||
Sequence: CKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIEC | ||||||
Lipidation | 345 | S-palmitoyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)42,688
- Last updated1994-02-01 v1
- Checksum107FEEDB09886F92
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 42 | in Ref. 2; BAA04109 | ||||
Sequence: V → L | ||||||
Sequence conflict | 345 | in Ref. 3; AAA41496 | ||||
Sequence: C → Y |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L22001 EMBL· GenBank· DDBJ | AAA41495.1 EMBL· GenBank· DDBJ | mRNA | ||
D16829 EMBL· GenBank· DDBJ | BAA04109.1 EMBL· GenBank· DDBJ | mRNA | ||
L22536 EMBL· GenBank· DDBJ | AAA41496.1 EMBL· GenBank· DDBJ | mRNA | ||
U00442 EMBL· GenBank· DDBJ | AAA18261.1 EMBL· GenBank· DDBJ | mRNA | ||
D16534 EMBL· GenBank· DDBJ | BAA03971.1 EMBL· GenBank· DDBJ | mRNA | ||
U17995 EMBL· GenBank· DDBJ | AAC53249.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U17993 EMBL· GenBank· DDBJ | AAC53249.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U17994 EMBL· GenBank· DDBJ | AAC53249.1 EMBL· GenBank· DDBJ | Genomic DNA |