P34619 · SOR1_CAEEL
- ProteinSop-2-related protein 1
- Genesor-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1000 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear body | |
Cellular Component | nuclear speck | |
Cellular Component | nucleoplasm | |
Molecular Function | RNA binding | |
Biological Process | epigenetic regulation of gene expression |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSop-2-related protein 1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionP34619
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Forms subnuclear bodies. Sop-2 is required for nuclear localization.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Worms exhibit early larval lethality and anterior to posterior cell fate transformation in a Hox gene-dependent manner. Hermaphrodites show vulva defects, partial hermaphrodite-to-male sexual transformation and are sterile.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000065562 | 1-1000 | Sop-2-related protein 1 | |||
Sequence: MTINIKYSSKFSSSKTSSSEELKPKTYIPAYYQPPVSMPKYYVNWLRIKLSLNKLKNIRAIYLFDQCQNFNQYQESSRKFSAGQVSSLTPWYSNFSNYSTVILRMKDTSLPPLENPSNGGTYLFNLITVFPSIALSFNYSWRGDTGPSISIFSFSLSVLFFSLFPQHKNICARAWCRPFRRSLSFSLRFIMSSEPASSSTEKVPEEPHPHSIKHKFQGPQFVIPRALSDYVLNVNNQTPESYEKALNAKYGRDDYITLCLHVTSLCTEYGPLDDGPEYVLLCDSRARVDKLIEDLVKLLEIDTDYVQLELHGGKRLHLQKPDAVLRDIAYKQSNEGSDKFFLEMKLVPSESMKAKIMKQEEEEEKARKHGQYQQYQEYHQQHQAMNDGQSSSSVPSTSSPSCSSEANRKEMETVREPAGPSELMRAINAPVAPAPVVIKIETPVALPEEDETLMDDDEMPSLTVEAPSEEASFEAEQPSPQVPQASIEGPSQQQQIPGTSQQKRQVARGSRTNMISYHDLPPGTGNAPPMACPQVTLKLEKNVPFEAKIRAVAGYTRKPISEVQKMRPSDLESIFHSICIASVQRIKRRNELVQQLQEINAQSCKSPTMTMNKKFTLAKAYQRVQNEIEKIDREQILPQQYMNMPPMPPQGQQRLPPPAYPPGILPPQQNRQQGVPPQFQRSPQFMIGPDGQRYAHPYMQLPNSNQRARILNTSSVQPSEEVRNRLVKIEAMAMNMAQLNPPRPPPPQPPHRALQGELQFLRPGAPDPCNFRPDSKQTYNNTYVTVASPATLTNSIIPWHFPPYEKSGRLNVSNTIKAINEYRLLCNSRQADPASFLEFYFLGDPMPHFNKILSIADYNMYLSRRRCDEADVKIHRMSHSDQLQLYLLELQSDESNVEKWKTFYRIMQWDLPLNNEFPRILLPSSLDIGRPVVDRKKKSIDQVMNHIHRMHSQRPPSMGNSSTSSEASSTSPTNAATATSSPASNRPTTSTAQPPTLNPT |
Proteomic databases
Expression
Developmental stage
Expressed at all developmental stages with levels declining as development proceeds.
Gene expression databases
Interaction
Subunit
Binds through its N-terminal region to the N-terminal region of sop-2.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P34619 | sop-2 Q965H3 | 4 | EBI-326963, EBI-331594 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 355-372 | Basic and acidic residues | ||||
Sequence: KIMKQEEEEEKARKHGQY | ||||||
Region | 355-374 | Disordered | ||||
Sequence: KIMKQEEEEEKARKHGQYQQ | ||||||
Compositional bias | 379-407 | Polar residues | ||||
Sequence: HQQHQAMNDGQSSSSVPSTSSPSCSSEAN | ||||||
Region | 379-422 | Disordered | ||||
Sequence: HQQHQAMNDGQSSSSVPSTSSPSCSSEANRKEMETVREPAGPSE | ||||||
Region | 466-509 | Disordered | ||||
Sequence: APSEEASFEAEQPSPQVPQASIEGPSQQQQIPGTSQQKRQVARG | ||||||
Compositional bias | 474-509 | Polar residues | ||||
Sequence: EAEQPSPQVPQASIEGPSQQQQIPGTSQQKRQVARG | ||||||
Region | 633-720 | RNA-binding | ||||
Sequence: REQILPQQYMNMPPMPPQGQQRLPPPAYPPGILPPQQNRQQGVPPQFQRSPQFMIGPDGQRYAHPYMQLPNSNQRARILNTSSVQPSE | ||||||
Region | 948-1000 | Disordered | ||||
Sequence: HRMHSQRPPSMGNSSTSSEASSTSPTNAATATSSPASNRPTTSTAQPPTLNPT | ||||||
Compositional bias | 954-1000 | Polar residues | ||||
Sequence: RPPSMGNSSTSSEASSTSPTNAATATSSPASNRPTTSTAQPPTLNPT |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P34619-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namea
- Length1,000
- Mass (Da)113,420
- Last updated1994-02-01 v1
- ChecksumD230C9A6F84928E2
P34619-2
- Nameb
- Differences from canonical
- 1-190: Missing
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_020783 | 1-190 | in isoform b | |||
Sequence: Missing | ||||||
Compositional bias | 355-372 | Basic and acidic residues | ||||
Sequence: KIMKQEEEEEKARKHGQY | ||||||
Compositional bias | 379-407 | Polar residues | ||||
Sequence: HQQHQAMNDGQSSSSVPSTSSPSCSSEAN | ||||||
Compositional bias | 474-509 | Polar residues | ||||
Sequence: EAEQPSPQVPQASIEGPSQQQQIPGTSQQKRQVARG | ||||||
Compositional bias | 954-1000 | Polar residues | ||||
Sequence: RPPSMGNSSTSSEASSTSPTNAATATSSPASNRPTTSTAQPPTLNPT |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO080723 EMBL· GenBank· DDBJ | CCD66163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080723 EMBL· GenBank· DDBJ | CCD66164.1 EMBL· GenBank· DDBJ | Genomic DNA |