P34508 · CRN6_CAEEL

  • Protein
    Cell death-related nuclease 6
  • Gene
    crn-6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Involved in apoptotic DNA degradation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functiondeoxyribonuclease II activity
Biological Processapoptotic DNA fragmentation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      crn-6
    • ORF names
      K04H4.6

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P34508
  • Secondary accessions
    • Q9NAQ0
    • Q9NCF8

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown results in accumulation of apoptotic DNA in 1.5-fold stage embryos.

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_000000729818-378Cell death-related nuclease 6
Glycosylation51N-linked (GlcNAc...) asparagine
Glycosylation92N-linked (GlcNAc...) asparagine
Glycosylation111N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the DNase II family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P34508-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    378
  • Mass (Da)
    43,348
  • Last updated
    2002-12-06 v3
  • Checksum
    E84D6C8F80EEF8F9
MIRQIILIVSLIGISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTKVLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCTKATAEKATLTVLLIAIITFFK

P34508-2

  • Name
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 364-378: ATLTVLLIAIITFFK → VDALANNRYF

Features

Showing features for sequence conflict, alternative sequence.

Type
IDPosition(s)Description
Sequence conflict40in Ref. 4; AAF43008
Sequence conflict267in Ref. 4; AAF43008
Alternative sequenceVSP_001304364-378in isoform a

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY303580
EMBL· GenBank· DDBJ
AAP57302.1
EMBL· GenBank· DDBJ
mRNA
Z27078
EMBL· GenBank· DDBJ
CAA81586.2
EMBL· GenBank· DDBJ
Genomic DNA
Z19153
EMBL· GenBank· DDBJ
CAA81586.2
EMBL· GenBank· DDBJ
Genomic DNA
Z27078
EMBL· GenBank· DDBJ
CAB76843.1
EMBL· GenBank· DDBJ
Genomic DNA
AF220525
EMBL· GenBank· DDBJ
AAF43008.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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