P34436 · MSRB_CAEEL
- ProteinProbable methionine-R-sulfoxide reductase B
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids152 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine (By similarity).
While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue (By similarity).
While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue (By similarity).
Catalytic activity
- L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol
RHEA-COMP:12313 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = RHEA-COMP:12314 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 66 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 69 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 116 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 119 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 140 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Biological Process | protein repair | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable methionine-R-sulfoxide reductase B
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionP34436
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000140325 | 1-152 | Probable methionine-R-sulfoxide reductase B | ||
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length152
- Mass (Da)17,212
- Last updated1994-02-01 v1
- MD5 Checksum3E25AF0727603AD87020C93122E0CBD4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q1W0S5 | Q1W0S5_CAEEL | CELE_F44E2.6 | 145 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO081383 EMBL· GenBank· DDBJ | CCD71223.1 EMBL· GenBank· DDBJ | Genomic DNA |