P34135 · HMDH1_DICDI
- Protein3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- GenehmgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids552 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis.
Catalytic activity
- (R)-mevalonate + 2 NADP+ + CoA = (3S)-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Pathway
Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 237 | Charge relay system | |||
Active site | 369 | Charge relay system | |||
Active site | 445 | Charge relay system | |||
Active site | 543 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | peroxisomal membrane | |
Molecular Function | hydroxymethylglutaryl-CoA reductase (NADPH) activity | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | coenzyme A metabolic process | |
Biological Process | isoprenoid biosynthetic process | |
Biological Process | sterol biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- EC number
- Short namesHMG-CoA reductase 1
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionP34135
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000114427 | 1-552 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 | ||
Glycosylation | 288 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 375 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 79-137 | Polar residues | |||
Region | 79-138 | Disordered | |||
Sequence similarities
Belongs to the HMG-CoA reductase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length552
- Mass (Da)60,387
- Last updated1994-02-01 v1
- Checksum3535CF268CDCE693
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 79-137 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L19349 EMBL· GenBank· DDBJ | AAA33214.1 EMBL· GenBank· DDBJ | mRNA | ||
AAFI02000005 EMBL· GenBank· DDBJ | EAL71921.1 EMBL· GenBank· DDBJ | Genomic DNA |