P34135 · HMDH1_DICDI

Function

function

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Features

Showing features for active site.

155250100150200250300350400450500550
TypeIDPosition(s)Description
Active site237Charge relay system
Active site369Charge relay system
Active site445Charge relay system
Active site543Proton donor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentperoxisomal membrane
Molecular Functionhydroxymethylglutaryl-CoA reductase (NADPH) activity
Biological Processcholesterol biosynthetic process
Biological Processcoenzyme A metabolic process
Biological Processisoprenoid biosynthetic process
Biological Processsterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
  • EC number
  • Short names
    HMG-CoA reductase 1

Gene names

    • Name
      hmgA
    • ORF names
      DDB_G0269142

Organism names

Accessions

  • Primary accession
    P34135
  • Secondary accessions
    • Q55CJ2

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00001144271-5523-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Glycosylation288N-linked (GlcNAc...) asparagine
Glycosylation375N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias79-137Polar residues
Region79-138Disordered

Sequence similarities

Belongs to the HMG-CoA reductase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    552
  • Mass (Da)
    60,387
  • Last updated
    1994-02-01 v1
  • Checksum
    3535CF268CDCE693
MLFAPPNLETKELFWIIYILILIPKVFAKVMSVRELFPFFKWGFNIRRSNFLVPILSNNVIVTGEEAVQYEKPLPYIPQHNQQQQQKQQPSQDYIQQPQNDNNINSGKEQEQQQQQQQQQQQTPDITNQPTKTNKKIPIKELSNEEILIKLEKGEVLAYRLENELGDCSRAVEIRRMLLEKQLSKKIEPIPHEGFDFAKVQGQCCENVIGYVPIPVGTAGPIQLNGQLVTIPMATTEGCLVASTHRGCKAITESGGAKCTITSRGMTRAPVVRFSDIVKASEFVSWINDTDNYQALKAVFDSTSRFARLSAIKCTIAGRSVYIRFKCDTGDAMGMNMVSKGVEAVLEHLKIIFDDMTLLSISGNMCTDKKPSSINWTEGRGRSVVCEAMITGDVVQRVLKTNVQALVDLNIAKNLIGSAMAGSIGGFNAHASNIVTAIFLATGQDCAQNVESSNCITQMEACNDGQDLYITVTMPSIEVGTVGGGTSLPAQSACLDIIGVKGSSSSKPGANADQLAKTIASAVMAGELSLMSALSAGHLMKSHLQYNRAKTN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias79-137Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L19349
EMBL· GenBank· DDBJ
AAA33214.1
EMBL· GenBank· DDBJ
mRNA
AAFI02000005
EMBL· GenBank· DDBJ
EAL71921.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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