P34022 · RANG_MOUSE
- ProteinRan-specific GTPase-activating protein
- GeneRanbp1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids203 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (PubMed:9428644).
Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity).
Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (PubMed:9428644).
Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity).
Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:9428644).
Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity).
Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity).
Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (PubMed:9428644).
Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity).
Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:9428644).
Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity).
Miscellaneous
Htf9a (RanBP1) and Htf9c are transcribed with opposite polarity from complementary DNA strands from a shared bidirectional TATA-less promoter.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon cytoplasm | |
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nuclear pore | |
Cellular Component | plasma membrane bounded cell projection cytoplasm | |
Molecular Function | GTPase activator activity | |
Biological Process | cellular response to leptomycin B | |
Biological Process | nucleocytoplasmic transport | |
Biological Process | positive regulation of mitotic centrosome separation | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | spindle organization |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameRan-specific GTPase-activating protein
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP34022
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000213668 | 2-203 | Ran-specific GTPase-activating protein | |||
Sequence: AAAKDSHEDHDTSTENADESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKGPGKNDNAEKVAEKLEALSVREAREEAEEKSEEKQ | ||||||
Modified residue | 13 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 21 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 60 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 150 | N6-acetyllysine; alternate | ||||
Sequence: K | ||||||
Modified residue | 150 | N6-succinyllysine; alternate | ||||
Sequence: K | ||||||
Modified residue | 182 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 187 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
2D gel databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN (PubMed:7891706, PubMed:8255297, PubMed:8896452).
Identified in a complex composed of RAN, RANGAP1 and RANBP1 (By similarity).
Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644).
Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (PubMed:9428644).
Identified in a complex with nucleotide-free RAN and RCC1 (By similarity).
Identified in a complex composed of RAN, RANGAP1 and RANBP1 (By similarity).
Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644).
Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (PubMed:9428644).
Identified in a complex with nucleotide-free RAN and RCC1 (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-23 | Basic and acidic residues | ||||
Sequence: MAAAKDSHEDHDTSTENADESNH | ||||||
Region | 1-33 | Disordered | ||||
Sequence: MAAAKDSHEDHDTSTENADESNHDPQFEPIVSL | ||||||
Domain | 26-164 | RanBD1 | ||||
Sequence: QFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEE | ||||||
Region | 163-203 | Disordered | ||||
Sequence: EEREKKGPGKNDNAEKVAEKLEALSVREAREEAEEKSEEKQ |
Sequence similarities
Belongs to the RANBP1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length203
- Mass (Da)23,596
- Last updated2004-04-13 v2
- Checksum4CA6C21DDF5B6F4F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H7BX22 | H7BX22_MOUSE | Ranbp1 | 153 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-23 | Basic and acidic residues | ||||
Sequence: MAAAKDSHEDHDTSTENADESNH | ||||||
Sequence conflict | 9 | in Ref. 2 | ||||
Sequence: E → A | ||||||
Sequence conflict | 22-24 | in Ref. 2 | ||||
Sequence: NHD → TTH | ||||||
Sequence conflict | 33 | in Ref. 1 and 2 | ||||
Sequence: L → V | ||||||
Sequence conflict | 67 | in Ref. 4; BAB25569 | ||||
Sequence: W → R | ||||||
Sequence conflict | 70-72 | in Ref. 2 | ||||
Sequence: RGT → PRH | ||||||
Sequence conflict | 85 | in Ref. 4; BAB25569 | ||||
Sequence: T → P | ||||||
Sequence conflict | 126 | in Ref. 2 and 3 | ||||
Sequence: A → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X56046 EMBL· GenBank· DDBJ | CAA39517.1 EMBL· GenBank· DDBJ | mRNA | ||
L25255 EMBL· GenBank· DDBJ | AAA16195.1 EMBL· GenBank· DDBJ | mRNA | ||
X56045 EMBL· GenBank· DDBJ | CAA39516.1 EMBL· GenBank· DDBJ | mRNA | ||
AK002989 EMBL· GenBank· DDBJ | BAB22501.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008276 EMBL· GenBank· DDBJ | BAB25569.1 EMBL· GenBank· DDBJ | mRNA | ||
AK088781 EMBL· GenBank· DDBJ | BAC40569.1 EMBL· GenBank· DDBJ | mRNA | ||
AK151167 EMBL· GenBank· DDBJ | BAE30170.1 EMBL· GenBank· DDBJ | mRNA | ||
AK166642 EMBL· GenBank· DDBJ | BAE38911.1 EMBL· GenBank· DDBJ | mRNA | ||
AK167053 EMBL· GenBank· DDBJ | BAE39217.1 EMBL· GenBank· DDBJ | mRNA | ||
BC061140 EMBL· GenBank· DDBJ | AAH61140.1 EMBL· GenBank· DDBJ | mRNA |