P34022 · RANG_MOUSE

  • Protein
    Ran-specific GTPase-activating protein
  • Gene
    Ranbp1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (PubMed:9428644).
Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity).
Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (PubMed:9428644).
Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity).
Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:9428644).
Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity).

Miscellaneous

Htf9a (RanBP1) and Htf9c are transcribed with opposite polarity from complementary DNA strands from a shared bidirectional TATA-less promoter.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon cytoplasm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnuclear pore
Cellular Componentplasma membrane bounded cell projection cytoplasm
Molecular FunctionGTPase activator activity
Biological Processcellular response to leptomycin B
Biological Processnucleocytoplasmic transport
Biological Processpositive regulation of mitotic centrosome separation
Biological Processpositive regulation of neuron projection development
Biological Processspindle organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ran-specific GTPase-activating protein
  • Alternative names
    • HpaII tiny fragments locus 9a protein
    • Ran-binding protein 1 (RANBP1)

Gene names

    • Name
      Ranbp1
    • Synonyms
      Htf9-a, Htf9a

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P34022
  • Secondary accessions
    • P34023
    • Q3TL81
    • Q9D894
    • Q9DCA3

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00002136682-203Ran-specific GTPase-activating protein
Modified residue13Phosphothreonine
Modified residue21Phosphoserine
Modified residue60Phosphoserine
Modified residue150N6-acetyllysine; alternate
Modified residue150N6-succinyllysine; alternate
Modified residue182N6-acetyllysine
Modified residue187Phosphoserine

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN (PubMed:7891706, PubMed:8255297, PubMed:8896452).
Identified in a complex composed of RAN, RANGAP1 and RANBP1 (By similarity).
Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644).
Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (PubMed:9428644).
Identified in a complex with nucleotide-free RAN and RCC1 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-23Basic and acidic residues
Region1-33Disordered
Domain26-164RanBD1
Region163-203Disordered

Sequence similarities

Belongs to the RANBP1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    203
  • Mass (Da)
    23,596
  • Last updated
    2004-04-13 v2
  • Checksum
    4CA6C21DDF5B6F4F
MAAAKDSHEDHDTSTENADESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKGPGKNDNAEKVAEKLEALSVREAREEAEEKSEEKQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H7BX22H7BX22_MOUSERanbp1153

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-23Basic and acidic residues
Sequence conflict9in Ref. 2
Sequence conflict22-24in Ref. 2
Sequence conflict33in Ref. 1 and 2
Sequence conflict67in Ref. 4; BAB25569
Sequence conflict70-72in Ref. 2
Sequence conflict85in Ref. 4; BAB25569
Sequence conflict126in Ref. 2 and 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X56046
EMBL· GenBank· DDBJ
CAA39517.1
EMBL· GenBank· DDBJ
mRNA
L25255
EMBL· GenBank· DDBJ
AAA16195.1
EMBL· GenBank· DDBJ
mRNA
X56045
EMBL· GenBank· DDBJ
CAA39516.1
EMBL· GenBank· DDBJ
mRNA
AK002989
EMBL· GenBank· DDBJ
BAB22501.1
EMBL· GenBank· DDBJ
mRNA
AK008276
EMBL· GenBank· DDBJ
BAB25569.1
EMBL· GenBank· DDBJ
mRNA
AK088781
EMBL· GenBank· DDBJ
BAC40569.1
EMBL· GenBank· DDBJ
mRNA
AK151167
EMBL· GenBank· DDBJ
BAE30170.1
EMBL· GenBank· DDBJ
mRNA
AK166642
EMBL· GenBank· DDBJ
BAE38911.1
EMBL· GenBank· DDBJ
mRNA
AK167053
EMBL· GenBank· DDBJ
BAE39217.1
EMBL· GenBank· DDBJ
mRNA
BC061140
EMBL· GenBank· DDBJ
AAH61140.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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