P33766 · FPR1_MOUSE
- ProteinfMet-Leu-Phe receptor
- GeneFpr1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids364 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity).
Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (By similarity).
Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor binding | |
Molecular Function | N-formyl peptide receptor activity | |
Molecular Function | RAGE receptor binding | |
Molecular Function | scavenger receptor binding | |
Biological Process | chemotaxis | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | phospholipase C-activating G protein-coupled receptor signaling pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namefMet-Leu-Phe receptor
- Short namesfMLP receptor
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP33766
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Internalizes in presence of its ligand, TAFA4.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-35 | Extracellular | ||||
Sequence: MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDV | ||||||
Transmembrane | 36-58 | Helical; Name=1 | ||||
Sequence: FSYLIFAVTFVLGVLGNGLVIWV | ||||||
Topological domain | 59-69 | Cytoplasmic | ||||
Sequence: AGFRMKHTVTT | ||||||
Transmembrane | 70-91 | Helical; Name=2 | ||||
Sequence: ISYLNLAIADFCFTSTLPFYIA | ||||||
Topological domain | 92-108 | Extracellular | ||||
Sequence: SMVMGGHWPFGWFMCKF | ||||||
Transmembrane | 109-129 | Helical; Name=3 | ||||
Sequence: IYTVIDINLFGSVFLIALIAL | ||||||
Topological domain | 130-148 | Cytoplasmic | ||||
Sequence: DRCICVLHPVWAQNHRTVS | ||||||
Transmembrane | 149-170 | Helical; Name=4 | ||||
Sequence: LAKKVIIVPWICAFLLTLPVII | ||||||
Topological domain | 171-216 | Extracellular | ||||
Sequence: RLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIR | ||||||
Transmembrane | 217-237 | Helical; Name=5 | ||||
Sequence: FIIGFSTPMSIVAICYGLITT | ||||||
Topological domain | 238-253 | Cytoplasmic | ||||
Sequence: KIHRQGLIKSSRPLRV | ||||||
Transmembrane | 254-277 | Helical; Name=6 | ||||
Sequence: LSFVVAAFFLCWCPFQVVALISTI | ||||||
Topological domain | 278-296 | Extracellular | ||||
Sequence: QVRERLKNMTPGIVTALKI | ||||||
Transmembrane | 297-316 | Helical; Name=7 | ||||
Sequence: TSPLAFFNSCLNPMLYVFMG | ||||||
Topological domain | 317-364 | Cytoplasmic | ||||
Sequence: QDFRERLIHSLPASLERALTEDSAQTSDTGTNLGTNSTSLSENTLNAM |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 28 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069446 | 1-364 | fMet-Leu-Phe receptor | |||
Sequence: MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMKHTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVRERLKNMTPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTSDTGTNLGTNSTSLSENTLNAM | ||||||
Glycosylation | 4 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 10 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 18 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 106↔187 | |||||
Sequence: CKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPNSRLGPGKTAC |
Post-translational modification
Phosphorylated; which is necessary for desensitization.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 335-364 | Disordered | ||||
Sequence: LTEDSAQTSDTGTNLGTNSTSLSENTLNAM |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length364
- Mass (Da)40,327
- Last updated1994-02-01 v1
- Checksum2F59193CF1D74DB2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L22181 EMBL· GenBank· DDBJ | AAA16110.1 EMBL· GenBank· DDBJ | Unassigned DNA | ||
AK137714 EMBL· GenBank· DDBJ | BAE23472.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466642 EMBL· GenBank· DDBJ | EDL20512.1 EMBL· GenBank· DDBJ | Genomic DNA |