P33338 · SLA2_YEAST

Function

function

Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H+-ATPase on the cell surface.

Miscellaneous

Present with 40600 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin cortical patch
Cellular Componentcellular bud neck
Cellular Componentcellular bud tip
Cellular Componentclathrin-coated vesicle
Cellular Componentcortical actin cytoskeleton
Cellular Componentincipient cellular bud site
Cellular Componentmating projection tip
Cellular Componentplasma membrane
Molecular Functionactin filament binding
Molecular Functionclathrin adaptor activity
Molecular Functionclathrin light chain binding
Molecular Functionphosphatidylinositol-3,4-bisphosphate binding
Molecular Functionphosphatidylinositol-3,5-bisphosphate binding
Biological Processactin cortical patch assembly
Biological Processactin filament organization
Biological Processclathrin coat assembly
Biological Processendocytosis
Biological Processnegative regulation of Arp2/3 complex-mediated actin nucleation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein SLA2
  • Alternative names
    • Transmembrane protein MOP2

Gene names

    • Name
      SLA2
    • Synonyms
      END4, MOP2, UFG1
    • ORF names
      N1102
    • Ordered locus names
      YNL243W

Organism names

Accessions

  • Primary accession
    P33338
  • Secondary accessions
    • D6W0V0
    • Q02434

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane772-791Helical

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000719451-968Protein SLA2
Modified residue294Phosphothreonine
Modified residue298Phosphothreonine
Modified residue308Phosphoserine
Modified residue555Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P33338ENT1 Q125183EBI-17323, EBI-31494
BINARY P33338LAS17 Q124463EBI-17323, EBI-10022
BINARY P33338SLA1 P327903EBI-17323, EBI-17313

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-127ENTH
Region280-324Disordered
Compositional bias290-306Pro residues
Compositional bias310-324Polar residues
Domain717-965I/LWEQ

Sequence similarities

Belongs to the SLA2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    968
  • Mass (Da)
    108,911
  • Last updated
    2011-09-21 v5
  • Checksum
    E592E09D8040C0E9
MSRIDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKLIREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLDEFSQIIFASIQSERRNTECKISALIPLIAESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTGMMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELFQQQLQKAQQDMMNMQLQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMDSTASKQLANKDEQLTALQDQLDVWERKYESLAKLYSQLRQEHLNLLPRFKKLQLKVNSAQESIQKKEQLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILESGINTIQESVYNLDSPLSWSGPLTPPTFLLSLLESTSENATEFATSFNNLIVDGLAHGDQTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLNIQSVKSNKETNPHSELVATADKIVKSSEHLRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIATTTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMIEDDHSTSQQQQPLDFTSEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHAYYNQDDD

Sequence caution

The sequence AAA19161.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict52in Ref. 2; AAA74726
Compositional bias290-306Pro residues
Compositional bias310-324Polar residues
Sequence conflict344in Ref. 3; CAA96148/CAA96149
Sequence conflict560in Ref. 5; AAA19161
Sequence conflict915in Ref. 5; AAA19161

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z22811
EMBL· GenBank· DDBJ
CAA80464.1
EMBL· GenBank· DDBJ
Genomic DNA
L12352
EMBL· GenBank· DDBJ
AAA74726.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71519
EMBL· GenBank· DDBJ
CAA96149.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71518
EMBL· GenBank· DDBJ
CAA96148.1
EMBL· GenBank· DDBJ
Genomic DNA
U07938
EMBL· GenBank· DDBJ
AAA19161.1
EMBL· GenBank· DDBJ
Unassigned DNA Frameshift
Z69381
EMBL· GenBank· DDBJ
CAA93355.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006947
EMBL· GenBank· DDBJ
DAA10316.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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