present evidence that despite extreme sequence divergence nibrin can at least partially replace Xrs2 in the cellular DNA damage response and Xrs2 is able to promote nuclear localization of MRE11.
Data show that ssDNA endodeoxyribonuclease SAE2 (Sae2) cooperates with the Mre11-Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair.
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