P33049 · CASA2_CAPHI

  • Protein
    Alpha-S2-casein
  • Gene
    CSN1S2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Important role in the capacity of milk to transport calcium phosphate.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionprotein homodimerization activity
Molecular Functionzymogen binding

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-S2-casein
  • Short names
    Alpha-S2-CN

Gene names

    • Name
      CSN1S2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra

Accessions

  • Primary accession
    P33049
  • Secondary accessions
    • Q9GK07
    • Q9MYU6
    • Q9MYU7
    • Q9TTQ7

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant22in allele F
Natural variant79in allele B
Natural variant161in allele 0
Natural variant182in allele C and allele E
Natural variant208in allele E

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 5 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Protein family/group databases

PTM/Processing

Features

Showing features for signal, chain, modified residue.

Type
IDPosition(s)Description
Signal1-15
ChainPRO_000000446316-223Alpha-S2-casein
Modified residue23Phosphoserine
Modified residue24Phosphoserine
Modified residue25Phosphoserine
Modified residue72Phosphoserine
Modified residue73Phosphoserine
Modified residue74Phosphoserine
Modified residue77Phosphoserine
Modified residue145Phosphoserine
Modified residue147Phosphoserine
Modified residue151Phosphoserine
Modified residue159Phosphoserine

Keywords

Expression

Tissue specificity

Mammary gland specific. Secreted in milk.

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat77-141
Repeat159-223

Sequence similarities

Belongs to the alpha-casein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    223
  • Mass (Da)
    26,389
  • Last updated
    1993-10-01 v1
  • Checksum
    187DEF42FD688291
MKFFIFTCLLAVALAKHKMEHVSSSEEPINIFQEIYKQEKNMAIHPRKEKLCTTSCEEVVRNANEEEYSIRSSSEESAEVAPEEIKITVDDKHYQKALNEINQFYQKFPQYLQYPYQGPIVLNPWDQVKRNAGPFTPTVNREQLSTSEENSKKTIDMESTEVFTKKTKLTEEEKNRLNFLKKISQYYQKFAWPQYLKTVDQHQKAMKPWTQPKTNAIPYVRYL

Polymorphism

The frequencies of the A, B and C alleles is estimated to be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and 'Saanen'.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X65160
EMBL· GenBank· DDBJ
CAA46278.1
EMBL· GenBank· DDBJ
mRNA
S74171
EMBL· GenBank· DDBJ
AAB32166.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ249995
EMBL· GenBank· DDBJ
CAB59920.1
EMBL· GenBank· DDBJ
mRNA
AJ289715
EMBL· GenBank· DDBJ
CAB94235.1
EMBL· GenBank· DDBJ
mRNA
AJ289716
EMBL· GenBank· DDBJ
CAB94236.1
EMBL· GenBank· DDBJ
mRNA
AJ297310
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ242526
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ242528
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ242527
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ242533
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ297311
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ297313
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ297315
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ297316
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ297314
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ297312
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA
AJ242728
EMBL· GenBank· DDBJ
CAC21704.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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