P33049 · CASA2_CAPHI
- ProteinAlpha-S2-casein
- GeneCSN1S2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids223 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Important role in the capacity of milk to transport calcium phosphate.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | protein homodimerization activity | |
Molecular Function | zymogen binding |
Keywords
- Molecular function
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-S2-casein
- Short namesAlpha-S2-CN
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra
Accessions
- Primary accessionP33049
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 22 | in allele F | |||
Natural variant | 79 | in allele B | |||
Natural variant | 161 | in allele 0 | |||
Natural variant | 182 | in allele C and allele E | |||
Natural variant | 208 | in allele E | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 5 variants from UniProt as well as other sources including ClinVar and dbSNP.
Protein family/group databases
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-15 | ||||
Chain | PRO_0000004463 | 16-223 | Alpha-S2-casein | ||
Modified residue | 23 | Phosphoserine | |||
Modified residue | 24 | Phosphoserine | |||
Modified residue | 25 | Phosphoserine | |||
Modified residue | 72 | Phosphoserine | |||
Modified residue | 73 | Phosphoserine | |||
Modified residue | 74 | Phosphoserine | |||
Modified residue | 77 | Phosphoserine | |||
Modified residue | 145 | Phosphoserine | |||
Modified residue | 147 | Phosphoserine | |||
Modified residue | 151 | Phosphoserine | |||
Modified residue | 159 | Phosphoserine | |||
Keywords
- PTM
Expression
Tissue specificity
Mammary gland specific. Secreted in milk.
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length223
- Mass (Da)26,389
- Last updated1993-10-01 v1
- Checksum187DEF42FD688291
Polymorphism
The frequencies of the A, B and C alleles is estimated to be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and 'Saanen'.
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X65160 EMBL· GenBank· DDBJ | CAA46278.1 EMBL· GenBank· DDBJ | mRNA | ||
S74171 EMBL· GenBank· DDBJ | AAB32166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ249995 EMBL· GenBank· DDBJ | CAB59920.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ289715 EMBL· GenBank· DDBJ | CAB94235.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ289716 EMBL· GenBank· DDBJ | CAB94236.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ297310 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ242526 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ242528 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ242527 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ242533 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ297311 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ297313 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ297315 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ297316 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ297314 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ297312 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ242728 EMBL· GenBank· DDBJ | CAC21704.2 EMBL· GenBank· DDBJ | Genomic DNA |