P32970 · CD70_HUMAN
- ProteinCD70 antigen
- GeneCD70
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids193 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892).
The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864).
The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | extracellular exosome | |
Cellular Component | plasma membrane | |
Molecular Function | receptor ligand activity | |
Molecular Function | tumor necrosis factor receptor binding | |
Biological Process | adaptive immune memory response involving T cells and B cells | |
Biological Process | B cell mediated immunity | |
Biological Process | B cell proliferation | |
Biological Process | CD27 signaling pathway | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | extrinsic apoptotic signaling pathway | |
Biological Process | positive regulation of T cell proliferation | |
Biological Process | T cell activation | |
Biological Process | T cell mediated immunity | |
Biological Process | tumor necrosis factor-mediated signaling pathway |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCD70 antigen
- Alternative names
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP32970
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-17 | Cytoplasmic | ||||
Sequence: MPEEGSGCSVRRRPYGC | ||||||
Transmembrane | 18-38 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: VLRAALVPLVAGLVICLVVCI | ||||||
Topological domain | 39-193 | Extracellular | ||||
Sequence: QRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Lymphoproliferative syndrome 3 (LPFS3)
- Note
- DescriptionAn autosomal recessive, early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus infection in B cells, abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have lymphadenopathy and hypogammaglobulinemia, and may suffer from recurrent infections.
- See alsoMIM:618261
Natural variants in LPFS3
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_081988 | 179-193 | missing | in LPFS3; loss of protein expression | |
VAR_081989 | 186-193 | missing | in LPFS3; no effect on protein expression; loss of interaction with CD27 |
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 61 | Decreased CD27 binding. | ||||
Sequence: Q → A | ||||||
Mutagenesis | 63 | Loss of protein expression. | ||||
Sequence: N → Q | ||||||
Mutagenesis | 65 | Loss of protein expression. | ||||
Sequence: T → A | ||||||
Mutagenesis | 80 | Decreased CD27 binding. | ||||
Sequence: A → R or F | ||||||
Mutagenesis | 83 | Loss of CD27 binding. | ||||
Sequence: R → A, E, or K | ||||||
Mutagenesis | 115 | No effect on protein expression but loss of CD27 binding; when associated with A-151. | ||||
Sequence: C → A | ||||||
Mutagenesis | 133 | Loss of protein expression; when associated with A-168. | ||||
Sequence: C → A | ||||||
Mutagenesis | 135 | Decreased protein expression. | ||||
Sequence: P → A | ||||||
Mutagenesis | 137 | No effect on CD27 binding. | ||||
Sequence: S → A or K | ||||||
Mutagenesis | 137 | Decreased CD27 binding. | ||||
Sequence: S → E | ||||||
Mutagenesis | 144 | Decreased CD27 binding. | ||||
Sequence: R → A or E | ||||||
Mutagenesis | 146 | No effect on CD27 binding. | ||||
Sequence: S → A | ||||||
Mutagenesis | 146 | Loss of CD27 binding. | ||||
Sequence: S → D | ||||||
Mutagenesis | 148 | Decreased CD27 binding. | ||||
Sequence: H → A, E, or D | ||||||
Mutagenesis | 151 | No effect on protein expression but loss of CD27 binding; when associated with A-115. | ||||
Sequence: C → A | ||||||
Mutagenesis | 165 | Decreased protein expression. | ||||
Sequence: D → A | ||||||
Mutagenesis | 168 | Loss of protein expression; when associated with A-133. | ||||
Sequence: C → A | ||||||
Mutagenesis | 170 | Decreased expression and decreased binding to CD27. | ||||
Sequence: N → Q | ||||||
Mutagenesis | 178 | Decreased CD27 binding. | ||||
Sequence: S → A | ||||||
Natural variant | VAR_081988 | 179-193 | in LPFS3; loss of protein expression | |||
Sequence: Missing | ||||||
Mutagenesis | 180 | Decreased CD27 binding. | ||||
Sequence: N → R or W | ||||||
Natural variant | VAR_081989 | 186-193 | in LPFS3; no effect on protein expression; loss of interaction with CD27 | |||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 282 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000185497 | 1-193 | CD70 antigen | |||
Sequence: MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP | ||||||
Glycosylation | 63 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 115↔151 | |||||
Sequence: CSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGC | ||||||
Disulfide bond | 133↔168 | |||||
Sequence: CSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLC | ||||||
Glycosylation | 170 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
N-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Homotrimer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P32970 | ELOVL4 Q9GZR5 | 3 | EBI-18539709, EBI-18535450 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 56-191 | THD | ||||
Sequence: DVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWV |
Sequence similarities
Belongs to the tumor necrosis factor family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P32970-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length193
- Mass (Da)21,118
- Last updated2002-06-06 v2
- Checksum9265856E33BE4D50
P32970-2
- Name2
- Differences from canonical
- 151-193: CTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP → LFGFWNWGLKVKCFLRHLIWTAHCFIPLTQLVFMQALQSWRNHHCSHFTDEENRGVNR
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M0QZW2 | M0QZW2_HUMAN | CD70 | 65 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_056416 | 151-193 | in isoform 2 | |||
Sequence: CTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP → LFGFWNWGLKVKCFLRHLIWTAHCFIPLTQLVFMQALQSWRNHHCSHFTDEENRGVNR | ||||||
Sequence conflict | 154 | in Ref. 1; AAA36175 | ||||
Sequence: A → V |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L08096 EMBL· GenBank· DDBJ | AAA36175.1 EMBL· GenBank· DDBJ | mRNA | ||
S69339 EMBL· GenBank· DDBJ | AAB30121.1 EMBL· GenBank· DDBJ | mRNA | ||
BT007211 EMBL· GenBank· DDBJ | AAP35875.1 EMBL· GenBank· DDBJ | mRNA | ||
AK298467 EMBL· GenBank· DDBJ | BAG60680.1 EMBL· GenBank· DDBJ | mRNA | ||
EF064709 EMBL· GenBank· DDBJ | ABK41892.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC008760 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471139 EMBL· GenBank· DDBJ | EAW69074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC000725 EMBL· GenBank· DDBJ | AAH00725.1 EMBL· GenBank· DDBJ | mRNA |