P32881 · IFNA8_HUMAN

  • Protein
    Interferon alpha-8
  • Gene
    IFNA8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functioncytokine receptor binding
Molecular Functiontype I interferon receptor binding
Biological Processadaptive immune response
Biological ProcessB cell differentiation
Biological ProcessB cell proliferation
Biological Processcellular response to virus
Biological Processcytokine-mediated signaling pathway
Biological Processdefense response to virus
Biological Processhumoral immune response
Biological Processnatural killer cell activation involved in immune response
Biological Processpositive regulation of peptidyl-serine phosphorylation of STAT protein
Biological Processresponse to exogenous dsRNA
Biological ProcessT cell activation involved in immune response
Biological Processtype I interferon-mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interferon alpha-8
  • Short names
    IFN-alpha-8
  • Alternative names
    • Interferon alpha-B (LeIF B)
    • Interferon alpha-B2

Gene names

    • Name
      IFNA8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P32881
  • Secondary accessions
    • P01565
    • P09236
    • Q5VWV7
    • Q5VYQ3

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_021975137in dbSNP:rs3739630

Variants

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The viewer provides 242 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, disulfide bond, chain.

TypeIDPosition(s)Description
Signal1-23
Disulfide bond24↔122
ChainPRO_000001636524-189Interferon alpha-8
Disulfide bond52↔162

Keywords

Proteomic databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P32881GPR152 Q8TDT23EBI-18211524, EBI-13345167
View interactors in UniProtKB
View CPX-6001 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the alpha/beta interferon family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    189
  • Mass (Da)
    21,989
  • Last updated
    1987-08-13 v1
  • Checksum
    83128DA2B6DBB2C1
MALTFYLLVALVVLSYKSFSSLGCDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict8in Ref. 3; CAA23806 and 4; CAA23811
Sequence conflict121-124in Ref. 3; CAA23806 and 4; CAA23811

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X03125
EMBL· GenBank· DDBJ
CAA26903.1
EMBL· GenBank· DDBJ
Genomic DNA
K01900
EMBL· GenBank· DDBJ
AAA52716.1
EMBL· GenBank· DDBJ
mRNA
V00545
EMBL· GenBank· DDBJ
CAA23806.1
EMBL· GenBank· DDBJ
mRNA
V00550
EMBL· GenBank· DDBJ
CAA23811.1
EMBL· GenBank· DDBJ
mRNA
AL353732
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471071
EMBL· GenBank· DDBJ
EAW58610.1
EMBL· GenBank· DDBJ
Genomic DNA
BC104828
EMBL· GenBank· DDBJ
AAI04829.1
EMBL· GenBank· DDBJ
mRNA
BC104830
EMBL· GenBank· DDBJ
AAI04831.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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