P32861 · UGPA1_YEAST
- ProteinUTP--glucose-1-phosphate uridylyltransferase
- GeneUGP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids499 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a central role as a glucosyl donor in cellular metabolic pathways.
Miscellaneous
Present with 17200 molecules/cell in log phase SD medium.
Catalytic activity
- alpha-D-glucose 1-phosphate + H+ + UTP = diphosphate + UDP-alpha-D-glucose
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 109-112 | UTP (UniProtKB | ChEBI) | ||||
Sequence: LNGG | ||||||
Binding site | 111-112 | substrate | ||||
Sequence: GG | ||||||
Binding site | 123 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 123 | UTP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 186 | UTP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 215 | UTP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 216 | substrate | ||||
Sequence: H | ||||||
Binding site | 244-246 | substrate | ||||
Sequence: NGD | ||||||
Binding site | 246 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 246 | UTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 388 | |||||
Sequence: K | ||||||
Binding site | 388 | UTP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | uridylyltransferase activity | |
Molecular Function | UTP:glucose-1-phosphate uridylyltransferase activity | |
Biological Process | (1->6)-beta-D-glucan biosynthetic process | |
Biological Process | glycogen biosynthetic process | |
Biological Process | glycogen metabolic process | |
Biological Process | trehalose biosynthetic process | |
Biological Process | UDP-glucose metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUTP--glucose-1-phosphate uridylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP32861
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000185765 | 2-499 | UTP--glucose-1-phosphate uridylyltransferase | |||
Sequence: STKKHTKTHSTYAFESNTNSVAASQMRNALNKLADSSKLDDAARAKFENELDSFFTLFRRYLVEKSSRTTLEWDKIKSPNPDEVVKYEIISQQPENVSNLSKLAVLKLNGGLGTSMGCVGPKSVIEVREGNTFLDLSVRQIEYLNRQYDSDVPLLLMNSFNTDKDTEHLIKKYSANRIRIRSFNQSRFPRVYKDSLLPVPTEYDSPLDAWYPPGHGDLFESLHVSGELDALIAQGREILFVSNGDNLGATVDLKILNHMIETGAEYIMELTDKTRADVKGGTLISYDGQVRLLEVAQVPKEHIDEFKNIRKFTNFNTNNLWINLKAVKRLIESSNLEMEIIPNQKTITRDGHEINVLQLETACGAAIRHFDGAHGVVVPRSRFLPVKTCSDLLLVKSDLFRLEHGSLKLDPSRFGPNPLIKLGSHFKKVSGFNARIPHIPKIVELDHLTITGNVFLGKDVTLRGTVIIVCSDGHKIDIPNGSILENVVVTGNLQILEH | ||||||
Modified residue | 17 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 19 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 21 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 79 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 369 | Omega-N-methylarginine | ||||
Sequence: R |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Homooctamer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P32861 | PSK1 P31374 | 4 | EBI-19987, EBI-9442 | |
BINARY | P32861 | PSK2 Q08217 | 3 | EBI-19987, EBI-9839 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 448-499 | Oligomerization | ||||
Sequence: HLTITGNVFLGKDVTLRGTVIIVCSDGHKIDIPNGSILENVVVTGNLQILEH |
Sequence similarities
Belongs to the UDPGP type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length499
- Mass (Da)55,988
- Last updated1993-10-01 v1
- Checksum9B9F4BED885E004D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X69584 EMBL· GenBank· DDBJ | CAA49303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z28035 EMBL· GenBank· DDBJ | CAA81872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006944 EMBL· GenBank· DDBJ | DAA09120.1 EMBL· GenBank· DDBJ | Genomic DNA |