P32847 · B3AT_ONCMY

Function

function

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionbicarbonate transmembrane transporter activity
Molecular Functionchloride:bicarbonate antiporter activity
Molecular Functionsolute:inorganic anion antiporter activity
Biological Processbicarbonate transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Band 3 anion exchange protein
  • Alternative names
    • Anion exchange protein 1 (AE 1; Anion exchanger 1)
    • Solute carrier family 4 member 1

Gene names

    • Name
      slc4a1
    • Synonyms
      ae1

Organism names

Accessions

  • Primary accession
    P32847

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-392Cytoplasmic
Transmembrane393-416Helical; Name=1
Topological domain417-424Extracellular
Transmembrane425-445Helical; Name=2
Topological domain446-448Cytoplasmic
Transmembrane449-465Discontinuously helical; Name=3
Topological domain466-474Extracellular
Transmembrane475-495Helical; Name=4
Topological domain496-507Cytoplasmic
Transmembrane508-530Helical; Name=5
Topological domain531-583Extracellular
Transmembrane584-604Helical; Name=6
Topological domain605-615Cytoplasmic
Transmembrane616-636Helical; Name=7
Topological domain637-676Extracellular
Transmembrane677-697Helical; Name=8
Topological domain698-713Cytoplasmic
Transmembrane714-732Helical; Name=9
Transmembrane733-750Discontinuously helical; Name=10
Topological domain751-769Cytoplasmic
Transmembrane770-790Helical; Name=11
Transmembrane791-809Helical; Name=12
Topological domain810-847Cytoplasmic
Intramembrane848-878Discontinuously helical
Topological domain879-918Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, lipidation.

TypeIDPosition(s)Description
ChainPRO_00000792131-918Band 3 anion exchange protein
Glycosylation546N-linked (GlcNAc...) asparagine
Glycosylation568N-linked (GlcNAc...) asparagine
Lipidation852S-palmitoyl cysteine

Keywords

PTM databases

Interaction

Subunit

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-16Acidic residues
Region1-48Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    918
  • Mass (Da)
    101,894
  • Last updated
    1996-02-01 v2
  • Checksum
    37E163141FBDC16A
MENDLSFGEDVMSYEEESDSAFPSPIRPTPPGHSGNYDLEQSRQEEDSNQAIQSIVVHTDPEAYLNLNTNANTRGDAQAYVELNELMGNSWQETGRWVGYEENFNPGTGKWGPSHVSYLTFKSLIQLRKIMSTGAIILDLQASSLSAVAEKVVDELRTKGEIRAADRDGLLRALLQRRSQSEGAVAQPLGGDIEMQTFSVTKQRDTTDSVEASIVLSGVMDSLEKPAVAFVRLGDSVVIEGALEAPVPVRFVFVLVGPSQGGVDYHESGRAMAALMADWVFSLEAYLAPTNKELTNAIADFMDCGIVIPPTEIQDEGMLQPIIDFQKKMLKDRLRPSDTRIIFGGGAKADEADEEPREDPLARTGIPFGGMIKDMKRRYRHYISDFTDALDPQVLAAVIFIYFAALSPAITFGGLLADKTEHMMGVSELMISTCVQGIIFAFIAAQPTLVIGFSGPLLVFEEAFFAFCKSQEIEYIVGRIWVGLWLVIIVVVIVAVEGSFLVKFISRFTQEIFSILISLIFIYETFSKLGKIFKAHPLVLNYEHLNDSLDNPFHPVVKEHIEYHEDGNKTVHEVIHERAYPNTALLSMCLMFGCFFIAYFLRQFKNGHFLPGPIRRMIGDFGVPIAIFFMIAVDITIEDAYTQKLVVPKGLMVSNPNARGWFINPLGEKKPFPAWMMGACCVPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLILVTMGGIASLFGVPWLSAATVRSVTHANALTVMSKGPKPEIEKVLEQRISGMLVAAMVGVSILLEPILKMIPMTALFGIFLYMGITSLSGIQMWDRMLLLIVPRKYYPADAYAQRVTTMKMHLFTLIQMVCLGALWMVKMSAFSLALPFVLILTIPLRMAITGTLFTDKEMKCLDASDGKVKFEEEPGEDMYESPLP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-16Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X61699
EMBL· GenBank· DDBJ
CAA43868.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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