P32797 · CDC13_YEAST
- ProteinCell division control protein 13
- GeneCDC13
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids924 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.
Miscellaneous
Present with 319 molecules/cell in log phase SD medium.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 500-686 | OB | ||||
Sequence: KMARKDPTIEFCQLGLDTFETKYITMFGMLVSCSFDKPAFISFVFSDFTKNDIVQNYLYDRYLIDYENKLELNEGFKAIMYKNQFETFDSKLRKIFNNGLRDLQNGRDENLSQYGIVCKMNIKVKMYNGKLNAIVRECEPVPHSQISSIASPSQCEHLRLFYQRAFKRIGESAISRYFEEYRRFFPI |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | CST complex | |
Cellular Component | nuclear telomere cap complex | |
Molecular Function | G-rich strand telomeric DNA binding | |
Molecular Function | identical protein binding | |
Molecular Function | single-stranded telomeric DNA binding | |
Molecular Function | telomerase inhibitor activity | |
Molecular Function | translation elongation factor binding | |
Biological Process | cell division | |
Biological Process | negative regulation of DNA duplex unwinding | |
Biological Process | regulation of telomere maintenance via telomerase | |
Biological Process | ribonucleoprotein complex localization | |
Biological Process | telomere capping | |
Biological Process | telomere maintenance | |
Biological Process | telomere maintenance via telomerase |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCell division control protein 13
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP32797
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 50 | Increase in length of X' and Y' telomeres. Disrupts interaction with POL1 but not FUN12. | ||||
Sequence: K → Q | ||||||
Mutagenesis | 72 | Disrupts interaction with POL1 and FUN12. | ||||
Sequence: I → T | ||||||
Mutagenesis | 124 | Disrupts interaction with POL1 but not FUN12. | ||||
Sequence: C → R | ||||||
Mutagenesis | 149 | Disrupts interaction with POL1 but not FUN12. | ||||
Sequence: L → S | ||||||
Mutagenesis | 228 | Disrupts interaction with POL1 but not FUN12. | ||||
Sequence: S → P | ||||||
Mutagenesis | 243 | Disrupts interaction with POL1 and FUN12. | ||||
Sequence: G → R | ||||||
Mutagenesis | 392 | Disrupts interaction with POL1 but not FUN12. | ||||
Sequence: L → P | ||||||
Mutagenesis | 523 | Increase in length of X' and Y' telomeres. Disrupts interaction with POL1 but not FUN12. | ||||
Sequence: I → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 32 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000089441 | 1-924 | Cell division control protein 13 | |||
Sequence: MDTLEEPECPPHKNRIFVSSSKDFEGYPSKAIVPVQFVALLTSIHLTETKCLLGFSNFERRGDQSQEDQYLIKLKFKDRGSERLARITISLLCQYFDIELPDLDSDSGASPTVILRDIHLERLCFSSCKALYVSKHGNYTLFLEDIKPLDLVSVISTISTKSTNSSKHSSSELISECDLNNSLVDIFNNLIEMNRDEKNRFKFVKLIHYDIELKKFVQDQQKVLSQKSKAAAINPFFVPNRLGIPYIESQNEFNSQLMTLNVDEPTTDISNMGEEMHDSADPIEDSDSSTTSSTGKYFSSKSYIQSQTPERKTSVPNNWHDDDSGSKRKRKLSFHSPNASSIRKAISYEQLSLASVGSVERLEGKIVGMNPPQFASINEFKYCTLKLYFTQLLPNVPDKVLVPGVNCIEIVIPTRERICELFGVLNCQSDKISDILLLEKPDRISVEVERILWDNDKTASPGMAVWSLKNISTDTQAQAQVQVPAQSSASIDPSRTRMSKMARKDPTIEFCQLGLDTFETKYITMFGMLVSCSFDKPAFISFVFSDFTKNDIVQNYLYDRYLIDYENKLELNEGFKAIMYKNQFETFDSKLRKIFNNGLRDLQNGRDENLSQYGIVCKMNIKVKMYNGKLNAIVRECEPVPHSQISSIASPSQCEHLRLFYQRAFKRIGESAISRYFEEYRRFFPIHRNGSHLAKLRFDEVKHEPKKSPTTPALAEHIPDLNADVSSFDVKFTDISSLLDSSARLPRPQQTHKSNTLYSCEGRIIAIEYHASDLCFHITNELPLLQTRGLAPERVLQLHIITSKNFAYFFNRSSAYLQRQPLEEKYTQLAQFLGHSFKFNITSSLTLFPDTTVALQIWCPIECTFRELQQQLAHPKVAAAPDSGSLDCAINATVNPLRLLAAQNGVTVKKEEDNDDDAGAVPTS | ||||||
Modified residue | 306 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 308 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 333 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with POL1, EST1, FUN12, STM1, STN1 and TEN1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P32797 | CDC13 P32797 | 4 | EBI-4187, EBI-4187 | |
BINARY | P32797 | EST1 P17214 | 3 | EBI-4187, EBI-6684 | |
BINARY | P32797 | POL1 P13382 | 4 | EBI-4187, EBI-6128 | |
BINARY | P32797 | SMT3 Q12306 | 3 | EBI-4187, EBI-17490 | |
BINARY | P32797 | STN1 P38960 | 10 | EBI-4187, EBI-18427 |
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 265-336 | Disordered | ||||
Sequence: PTTDISNMGEEMHDSADPIEDSDSSTTSSTGKYFSSKSYIQSQTPERKTSVPNNWHDDDSGSKRKRKLSFHS | ||||||
Compositional bias | 270-284 | Basic and acidic residues | ||||
Sequence: SNMGEEMHDSADPIE | ||||||
Compositional bias | 285-314 | Polar residues | ||||
Sequence: DSDSSTTSSTGKYFSSKSYIQSQTPERKTS | ||||||
Compositional bias | 315-330 | Basic and acidic residues | ||||
Sequence: VPNNWHDDDSGSKRKR |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length924
- Mass (Da)104,904
- Last updated2002-07-11 v2
- Checksum9FE0AD08520A6F8A
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 40 | in Ref. 1; AAA99990 | ||||
Sequence: L → A | ||||||
Compositional bias | 270-284 | Basic and acidic residues | ||||
Sequence: SNMGEEMHDSADPIE | ||||||
Compositional bias | 285-314 | Polar residues | ||||
Sequence: DSDSSTTSSTGKYFSSKSYIQSQTPERKTS | ||||||
Compositional bias | 315-330 | Basic and acidic residues | ||||
Sequence: VPNNWHDDDSGSKRKR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M76550 EMBL· GenBank· DDBJ | AAA99990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z74269 EMBL· GenBank· DDBJ | CAA98800.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006938 EMBL· GenBank· DDBJ | DAA11644.1 EMBL· GenBank· DDBJ | Genomic DNA |