P32738 · CLAT_RAT
- ProteinCholine O-acetyltransferase
- GeneChat
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids640 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Catalytic activity
- acetyl-CoA + choline = acetylcholine + CoA
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cytoplasm | |
Cellular Component | neuron projection | |
Cellular Component | neuronal cell body | |
Cellular Component | synapse | |
Molecular Function | choline binding | |
Molecular Function | choline O-acetyltransferase activity | |
Biological Process | acetylcholine biosynthetic process | |
Biological Process | adult walking behavior | |
Biological Process | antral ovarian follicle growth | |
Biological Process | chemical synaptic transmission | |
Biological Process | dendrite development | |
Biological Process | establishment of synaptic specificity at neuromuscular junction | |
Biological Process | memory | |
Biological Process | muscle organ development | |
Biological Process | neuromuscular synaptic transmission | |
Biological Process | neuron differentiation | |
Biological Process | response to ethanol | |
Biological Process | response to hypoxia | |
Biological Process | response to nutrient | |
Biological Process | response to xenobiotic stimulus | |
Biological Process | rhythmic behavior | |
Biological Process | rhythmic excitation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCholine O-acetyltransferase
- EC number
- Short namesCHOACTase; ChAT; Choline acetylase
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP32738
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 453 | Increases KM for coenzyme A and acetylcholine. | ||||
Sequence: R → A, E, or Q |
Chemistry
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000210157 | 1-640 | Choline O-acetyltransferase | |||
Sequence: MPILEKAPQKMPVKASSWEELDLPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAIVKRFGAPGGLGETLQEKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFQDTNDQLRFAACLISGVLSYKTLLDSHSLPTDWAKGQLSGQPLCMKQYYRLFSSYRLPGHTQDTLVAQKSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAKARTVLLKDSTNRDSLDMIERCICLVCLDGPGTGELSDTHRALQLLHGGGCSLNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMMTSNKKLVRADSVSELPAPRRLRLKCSPETQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKYSPDGFIQVALQLAYYRLYQRLVPTYESASIRRFQEGRVDNIRSATPEALAFVQAMTDHKAAMPASEKLQLLQTAMQAHKQYTVMAITGMAIDNHLLALRELARDLCKEPPEMFMDETYLMSNRFVLSTSQVPTTMEMFCCYGPVVPNGNGACYNPQPEAITFCISSFHSCKETSSVEFAEAVGASLVDMRDLCSSRQPADSKPPAPKEKARGPSQAKQS | ||||||
Modified residue | 17 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 365 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 614-640 | Disordered | ||||
Sequence: CSSRQPADSKPPAPKEKARGPSQAKQS |
Sequence similarities
Belongs to the carnitine/choline acetyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length640
- Mass (Da)71,864
- Last updated2007-01-23 v2
- ChecksumE5FEA20EBBFA2EC6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M88488 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |