P32362 · DCUP_RAT
- ProteinUroporphyrinogen decarboxylase
- GeneUrod
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids364 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.
Catalytic activity
- uroporphyrinogen III + 4 H+ = coproporphyrinogen III + 4 CO2This reaction proceeds in the forward direction.
- uroporphyrinogen I + 4 H+ = coproporphyrinogen I + 4 CO2This reaction proceeds in the forward direction.
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 34-38 | substrate | |||
Binding site | 52 | substrate | |||
Binding site | 82 | substrate | |||
Binding site | 83 | substrate | |||
Site | 83 | Transition state stabilizer | |||
Binding site | 161 | substrate | |||
Binding site | 216 | substrate | |||
Binding site | 336 | substrate | |||
GO annotations
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUroporphyrinogen decarboxylase
- EC number
- Short namesUPD; URO-D
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP32362
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000187571 | 1-364 | Uroporphyrinogen decarboxylase | ||
Proteomic databases
PTM databases
Interaction
Structure
Sequence
- Sequence statusFragment
- Length364
- Mass (Da)40,453
- Last updated1993-10-01 v1
- MD5 Checksum500CBFE1F461930CB75EC9758CAEE790
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AHK9 | A0A8I6AHK9_RAT | Urod | 374 | ||
B0BN55 | B0BN55_RAT | Urod | 367 | ||
A0A8I6ADE7 | A0A8I6ADE7_RAT | Urod | 332 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y00350 EMBL· GenBank· DDBJ | CAB50784.1 EMBL· GenBank· DDBJ | mRNA |