P32362 · DCUP_RAT

  • Protein
    Uroporphyrinogen decarboxylase
  • Gene
    Urod
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site34-38substrate
Binding site52substrate
Binding site82substrate
Binding site83substrate
Site83Transition state stabilizer
Binding site161substrate
Binding site216substrate
Binding site336substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionferrous iron binding
Molecular Functionuroporphyrinogen decarboxylase activity
Biological Processcellular response to arsenic-containing substance
Biological Processheme A biosynthetic process
Biological Processheme B biosynthetic process
Biological Processheme biosynthetic process
Biological Processheme metabolic process
Biological Processheme O biosynthetic process
Biological Processliver development
Biological Processporphyrin-containing compound biosynthetic process
Biological Processporphyrin-containing compound catabolic process
Biological Processporphyrin-containing compound metabolic process
Biological Processprotoporphyrinogen IX biosynthetic process
Biological Processresponse to amine
Biological Processresponse to estradiol
Biological Processresponse to ethanol
Biological Processresponse to fungicide
Biological Processresponse to iron ion
Biological Processresponse to mercury ion
Biological Processresponse to methylmercury
Biological Processresponse to organic cyclic compound
Biological Processuroporphyrinogen III metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uroporphyrinogen decarboxylase
  • EC number
  • Short names
    UPD; URO-D

Gene names

    • Name
      Urod

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P32362

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001875711-364Uroporphyrinogen decarboxylase

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    364
  • Mass (Da)
    40,453
  • Last updated
    1993-10-01 v1
  • MD5 Checksum
    500CBFE1F461930CB75EC9758CAEE790
NGLGLQNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLEPVRRFPLDAAIIFSDILVVPQALAMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQQLAGRVPLIGFAGAPWTLMTYMVEGGSFKTMAQAKRWLYQKPVASHKLLGILTHALVPYLIGQVAAGAQALQLFESHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLTRMPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAREPVGKTVTLQGELDPCALYASEEEIGRLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFLDAVHKHSRLLRQN

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AHK9A0A8I6AHK9_RATUrod374
B0BN55B0BN55_RATUrod367
A0A8I6ADE7A0A8I6ADE7_RATUrod332

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y00350
EMBL· GenBank· DDBJ
CAB50784.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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