P32320 · CDD_HUMAN
- ProteinCytidine deaminase
- GeneCDA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids146 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Catalytic activity
- cytidine + H+ + H2O = NH4+ + uridine
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | extracellular region | |
Cellular Component | ficolin-1-rich granule lumen | |
Cellular Component | secretory granule lumen | |
Cellular Component | tertiary granule lumen | |
Molecular Function | cytidine deaminase activity | |
Molecular Function | identical protein binding | |
Molecular Function | nucleoside binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | zinc ion binding | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | cellular response to external biotic stimulus | |
Biological Process | cytidine deamination | |
Biological Process | cytosine metabolic process | |
Biological Process | negative regulation of cell growth | |
Biological Process | negative regulation of nucleotide metabolic process | |
Biological Process | pyrimidine-containing compound salvage | |
Biological Process | response to cycloheximide | |
Biological Process | UMP salvage |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytidine deaminase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP32320
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_021559 | 27 | in dbSNP:rs2072671 | |||
Sequence: K → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 423 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000171682 | 1-146 | Cytidine deaminase | |||
Sequence: MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ |
Proteomic databases
PTM databases
Interaction
Subunit
Homotetramer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P32320 | ADAT3 Q96EY9 | 3 | EBI-9250559, EBI-3922811 | |
BINARY | P32320 | ARRDC3 Q96B67 | 5 | EBI-9250559, EBI-2875665 | |
BINARY | P32320 | CDA P32320 | 4 | EBI-9250559, EBI-9250559 | |
BINARY | P32320 | DDIT4L Q96D03 | 5 | EBI-9250559, EBI-742054 | |
BINARY | P32320 | FNDC11 Q9BVV2 | 6 | EBI-9250559, EBI-744935 | |
BINARY | P32320 | FOXN1 O15353 | 3 | EBI-9250559, EBI-11319000 | |
BINARY | P32320 | GORASP2 Q9H8Y8 | 3 | EBI-9250559, EBI-739467 | |
BINARY | P32320 | INCA1 Q0VD86 | 3 | EBI-9250559, EBI-6509505 | |
BINARY | P32320 | KRTAP6-1 Q3LI64 | 3 | EBI-9250559, EBI-12111050 | |
BINARY | P32320 | KRTAP8-1 Q8IUC2 | 3 | EBI-9250559, EBI-10261141 | |
BINARY | P32320 | LNX1 Q8TBB1 | 9 | EBI-9250559, EBI-739832 | |
BINARY | P32320 | NTAQ1 Q96HA8 | 9 | EBI-9250559, EBI-741158 | |
BINARY | P32320 | PLEKHB2 Q96CS7 | 6 | EBI-9250559, EBI-373552 | |
BINARY | P32320 | PSMA1 P25786 | 3 | EBI-9250559, EBI-359352 | |
BINARY | P32320 | PTGER3 P43115-12 | 3 | EBI-9250559, EBI-10234038 | |
BINARY | P32320 | SDCBP O00560 | 6 | EBI-9250559, EBI-727004 | |
BINARY | P32320 | ZBTB24 O43167 | 6 | EBI-9250559, EBI-744471 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 13-140 | CMP/dCMP-type deaminase | ||||
Sequence: ECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPE |
Sequence similarities
Belongs to the cytidine and deoxycytidylate deaminase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length146
- Mass (Da)16,185
- Last updated1996-10-01 v2
- ChecksumAF33D09EE4E176B3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L27943 EMBL· GenBank· DDBJ | AAA57254.1 EMBL· GenBank· DDBJ | mRNA | ||
AF061658 EMBL· GenBank· DDBJ | AAD15828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF061655 EMBL· GenBank· DDBJ | AAD15828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF061656 EMBL· GenBank· DDBJ | AAD15828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF061657 EMBL· GenBank· DDBJ | AAD15828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ000474 EMBL· GenBank· DDBJ | CAA04113.1 EMBL· GenBank· DDBJ | mRNA | ||
AL391357 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC054036 EMBL· GenBank· DDBJ | AAH54036.1 EMBL· GenBank· DDBJ | mRNA | ||
S52873 EMBL· GenBank· DDBJ | AAB24946.1 EMBL· GenBank· DDBJ | mRNA |