P31650 · S6A11_MOUSE

  • Protein
    Sodium- and chloride-dependent GABA transporter 3
  • Gene
    Slc6a11
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:30270321, PubMed:8420981).
Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (PubMed:30270321, PubMed:8420981).

Catalytic activity

  • 4-aminobutanoate(out) + chloride(out) + 2 Na+(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na+(in)
    This reaction proceeds in the forward direction.
  • chloride(out) + 2 Na+(out) + taurine(out) = chloride(in) + 2 Na+(in) + taurine(in)
    This reaction proceeds in the forward direction.
  • beta-alanine(out) + chloride(out) + 2 Na+(out) = beta-alanine(in) + chloride(in) + 2 Na+(in)
    This reaction proceeds in the forward direction.
  • chloride(out) + hypotaurine(out) + 2 Na+(out) = chloride(in) + hypotaurine(in) + 2 Na+(in)
    This reaction proceeds in the forward direction.

Activity regulation

GABA transport is inhibited by beta-alanine, taurine, hypotaurine, beta-guanidinopropionic acid and 2,3-diaminopropionic acid (PubMed:8420981).
Beta-alanine transport is inhibited by GABA (PubMed:8420981).

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.8 μMGABA
2.24 μMGABA
99 μMbeta-alanine
1.4 mMtaurine

GO annotations

AspectTerm
Cellular Componentcell projection
Cellular ComponentGABA-ergic synapse
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentpresynaptic membrane
Cellular Componentsynapse
Molecular Functionamino acid binding
Molecular Functionamino acid:sodium symporter activity
Molecular Functiongamma-aminobutyric acid:sodium:chloride symporter activity
Molecular Functiontaurine:sodium symporter activity
Biological Processamino acid transport
Biological Processneurotransmitter transport
Biological Processneurotransmitter uptake
Biological Processresponse to xenobiotic stimulus
Biological Processsodium ion transmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium- and chloride-dependent GABA transporter 3
  • Short names
    GAT-3
  • Alternative names
    • Sodium- and chloride-dependent GABA transporter 4
      (GAT-4
      )
    • Solute carrier family 6 member 11

Gene names

    • Name
      Slc6a11
    • Synonyms
      Gabt3, Gabt4, Gat-4
      , Gat3, Gat4

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P31650
  • Secondary accessions
    • Q8BWA7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-53Cytoplasmic
Transmembrane54-74Helical; Name=1
Transmembrane82-101Helical; Name=2
Transmembrane126-146Helical; Name=3
Topological domain147-220Extracellular
Transmembrane221-239Helical; Name=4
Transmembrane248-265Helical; Name=5
Transmembrane301-318Helical; Name=6
Transmembrane330-351Helical; Name=7
Transmembrane384-403Helical; Name=8
Transmembrane433-451Helical; Name=9
Transmembrane468-488Helical; Name=10
Transmembrane509-528Helical; Name=11
Transmembrane548-566Helical; Name=12
Topological domain567-627Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, modified residue, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002147851-627Sodium- and chloride-dependent GABA transporter 3
Modified residue21Phosphoserine
Glycosylation182N-linked (GlcNAc...) asparagine
Glycosylation185N-linked (GlcNAc...) asparagine
Glycosylation193N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain.

Gene expression databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-36Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    627
  • Mass (Da)
    69,961
  • Last updated
    2011-07-27 v2
  • Checksum
    7BCCFA2000DB024F
MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKETHF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L04662
EMBL· GenBank· DDBJ
-mRNA No translation available.
AK053078
EMBL· GenBank· DDBJ
BAC35259.1
EMBL· GenBank· DDBJ
mRNA
AK140423
EMBL· GenBank· DDBJ
BAE24379.1
EMBL· GenBank· DDBJ
mRNA
CH466523
EMBL· GenBank· DDBJ
EDK99507.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp