P31625 · PRO_JSRV
- ProteinGag-Pro polyprotein
- Genepro
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids866 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Matrix protein p10
Capsid protein p27
Protease 17 kDa
Protease 13 kDa
G-patch peptide
Catalytic activity
- dUTP + H2O = diphosphate + dUMP + H+
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 99-100 | Cleavage; by viral protease | ||||
Sequence: LG | ||||||
Site | 256-257 | Cleavage; by viral protease | ||||
Sequence: FP | ||||||
Site | 477-478 | Cleavage; by viral protease | ||||
Sequence: MA | ||||||
Site | 713-714 | Cleavage; by viral protease | ||||
Sequence: YW | ||||||
Active site | 739 | Protease; shared with dimeric partner | ||||
Sequence: D | ||||||
Site | 831-832 | Cleavage; by viral protease | ||||
Sequence: DQ |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | viral nucleocapsid | |
Molecular Function | aspartic-type endopeptidase activity | |
Molecular Function | DNA binding | |
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | structural constituent of virion | |
Molecular Function | zinc ion binding | |
Biological Process | nucleotide metabolic process | |
Biological Process | proteolysis | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGag-Pro polyprotein
- Cleaved into 8 chains
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Betaretrovirus
- Virus hosts
Accessions
- Primary accessionP31625
Proteomes
PTM/Processing
Features
Showing features for initiator methionine, chain, peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed; by host | ||||
Sequence: M | ||||||
Chain | PRO_0000443182 | 2-99 | Matrix protein p10 | |||
Sequence: GHTHSRQLFVHMLSVMLKHRGITVSKTKLINFLSFIEEVCPWFPREGTVNLETWKKVGEQIRTHYTLHGPEKVPVETLSFWTLIRDCLDFDNDELKRL | ||||||
Chain | PRO_0000199548 | 2-866 | Gag-Pro polyprotein | |||
Sequence: GHTHSRQLFVHMLSVMLKHRGITVSKTKLINFLSFIEEVCPWFPREGTVNLETWKKVGEQIRTHYTLHGPEKVPVETLSFWTLIRDCLDFDNDELKRLGNLLKQEEDPLHTPDSVPSYDPPPPPPPSLKMHPSDNDDSLSSTDEAELDEEAAKYHQEDWGFLAQEKGALTSKDELVECFKNLTIALQNAGIQLPSNNNTFPSAPPFPPAYTPTVMAGLDPPPGFPPPSKHMSPLQKALRQAQRLGEVVSDFSLAFPVFENNNQRYYESLPFKQLKELKIACSQYGPTAPFTIAMIESLGTQALPPNDWKQTARACLSGGDYLLWKSEFFEQCARIADVNRQQGIQTSYEMLIGEGPYQATDTQLNFLPGAYAQISNAARQAWKKLPSSSTKTEDLSKVRQGPDEPYQDFVARLLDTIGKIMSDEKAGMVLAKQLAFENANSACQAALRPYRKKGDLSDFIRICADIGPSYMQGIAMAAALQGKSIKEVLFQQQARNKKGLQKSGNSGCFVCGQPGHRAAVCPQKHQTSVNTPNLCPRCKKGKHWARDCRSKTDVQGNPLPPVSGNLGEGPAPGPETMLWGNTAGSKRTIADLCRATRGSAGLDLCATSYTVLTPEMGVQTLATGVFGPLPPGTVGLLLGRSSASLKGILIHPGVIDSDYTGEIKILASAPNKIIVINAGQRIAQLLLVPLVIQGKTINRDRQDKGFGSSDAYWVQNVTEARPELELRINANFFRGVLDTGADISVISDKYWPTTWPKQMAISTLQGIGQTTNPEQSSSLLTWKDKDGHTGQFKPYILPYLPVNLWGRDILSKMGVYLYSPSPTVTDLMLDQGLLPNQGLGKQHQGIILPLDLKPNQDRKGLGCFP | ||||||
Chain | PRO_0000443183 | 100-167 | Phosphorylated protein | |||
Sequence: GNLLKQEEDPLHTPDSVPSYDPPPPPPPSLKMHPSDNDDSLSSTDEAELDEEAAKYHQEDWGFLAQEK | ||||||
Chain | PRO_0000443184 | 168-256 | p12 | |||
Sequence: GALTSKDELVECFKNLTIALQNAGIQLPSNNNTFPSAPPFPPAYTPTVMAGLDPPPGFPPPSKHMSPLQKALRQAQRLGEVVSDFSLAF | ||||||
Chain | PRO_0000443185 | 257-477 | Capsid protein p27 | |||
Sequence: PVFENNNQRYYESLPFKQLKELKIACSQYGPTAPFTIAMIESLGTQALPPNDWKQTARACLSGGDYLLWKSEFFEQCARIADVNRQQGIQTSYEMLIGEGPYQATDTQLNFLPGAYAQISNAARQAWKKLPSSSTKTEDLSKVRQGPDEPYQDFVARLLDTIGKIMSDEKAGMVLAKQLAFENANSACQAALRPYRKKGDLSDFIRICADIGPSYMQGIAM | ||||||
Chain | PRO_0000443186 | 478-713 | Nucleocapsid protein-dUTPase | |||
Sequence: AAALQGKSIKEVLFQQQARNKKGLQKSGNSGCFVCGQPGHRAAVCPQKHQTSVNTPNLCPRCKKGKHWARDCRSKTDVQGNPLPPVSGNLGEGPAPGPETMLWGNTAGSKRTIADLCRATRGSAGLDLCATSYTVLTPEMGVQTLATGVFGPLPPGTVGLLLGRSSASLKGILIHPGVIDSDYTGEIKILASAPNKIIVINAGQRIAQLLLVPLVIQGKTINRDRQDKGFGSSDAY | ||||||
Chain | PRO_0000443188 | 714-831 | Protease 13 kDa | |||
Sequence: WVQNVTEARPELELRINANFFRGVLDTGADISVISDKYWPTTWPKQMAISTLQGIGQTTNPEQSSSLLTWKDKDGHTGQFKPYILPYLPVNLWGRDILSKMGVYLYSPSPTVTDLMLD | ||||||
Chain | PRO_0000443187 | 714-866 | Protease 17 kDa | |||
Sequence: WVQNVTEARPELELRINANFFRGVLDTGADISVISDKYWPTTWPKQMAISTLQGIGQTTNPEQSSSLLTWKDKDGHTGQFKPYILPYLPVNLWGRDILSKMGVYLYSPSPTVTDLMLDQGLLPNQGLGKQHQGIILPLDLKPNQDRKGLGCFP | ||||||
Peptide | PRO_0000443189 | 832-866 | G-patch peptide | |||
Sequence: QGLLPNQGLGKQHQGIILPLDLKPNQDRKGLGCFP |
Post-translational modification
Protease 17 kDa
Gag-Pro polyprotein
Gag-Pro polyprotein
Keywords
- PTM
Interaction
Subunit
Protease 17 kDa
G-patch peptide
Nucleocapsid protein-dUTPase
Family & Domains
Features
Showing features for region, compositional bias, motif, zinc finger, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 103-148 | Disordered | ||||
Sequence: LKQEEDPLHTPDSVPSYDPPPPPPPSLKMHPSDNDDSLSSTDEAEL | ||||||
Compositional bias | 115-131 | Pro residues | ||||
Sequence: SVPSYDPPPPPPPSLKM | ||||||
Motif | 202-205 | PTAP/PSAP motif | ||||
Sequence: PSAP | ||||||
Motif | 208-211 | PPXY motif | ||||
Sequence: PPAY | ||||||
Motif | 287-290 | PTAP/PSAP motif | ||||
Sequence: PTAP | ||||||
Zinc finger | 507-524 | CCHC-type | ||||
Sequence: SGCFVCGQPGHRAAVCPQ | ||||||
Region | 550-570 | Disordered | ||||
Sequence: RSKTDVQGNPLPPVSGNLGEG | ||||||
Domain | 734-810 | Peptidase A2 | ||||
Sequence: FRGVLDTGADISVISDKYWPTTWPKQMAISTLQGIGQTTNPEQSSSLLTWKDKDGHTGQFKPYILPYLPVNLWGRDI | ||||||
Domain | 821-866 | G-patch | ||||
Sequence: PSPTVTDLMLDQGLLPNQGLGKQHQGIILPLDLKPNQDRKGLGCFP |
Domain
Protease 17 kDa
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Ribosomal frameshifting.
P31625-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameGag-Pro polyprotein
- NoteProduced by -1 ribosomal frameshifting between gag-pro.
- Length866
- Mass (Da)95,245
- Last updated2018-02-28 v3
- Checksum50C1920E2C6C335E
P31622-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameGag polyprotein
P31623-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameGag-Pro-Pol polyprotein
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 115-131 | Pro residues | ||||
Sequence: SVPSYDPPPPPPPSLKM |
Keywords
- Coding sequence diversity
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M80216 EMBL· GenBank· DDBJ | AAA89181.1 EMBL· GenBank· DDBJ | Genomic RNA |