P31392 · GP182_RAT
- ProteinG-protein coupled receptor 182
- GeneGpr182
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids395 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Orphan receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adrenomedullin receptor activity | |
Biological Process | response to hypoxia |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameG-protein coupled receptor 182
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP31392
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-53 | Extracellular | ||||
Sequence: MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLF | ||||||
Transmembrane | 54-75 | Helical; Name=1 | ||||
Sequence: VFYLAIFVVGLVENVLVICVNC | ||||||
Topological domain | 76-86 | Cytoplasmic | ||||
Sequence: RRSGRVGMLNL | ||||||
Transmembrane | 87-109 | Helical; Name=2 | ||||
Sequence: YILNMAVADLGIILSLPVWMLEV | ||||||
Topological domain | 110-123 | Extracellular | ||||
Sequence: MLEYTWLWGSFSCR | ||||||
Transmembrane | 124-145 | Helical; Name=3 | ||||
Sequence: FIHYFYLANMYSSIFFLTCLSI | ||||||
Topological domain | 146-166 | Cytoplasmic | ||||
Sequence: DRYVTLTNTSPSWQRHQHRIR | ||||||
Transmembrane | 167-189 | Helical; Name=4 | ||||
Sequence: RAVCAGVWVLSAIIPLPEVVHIQ | ||||||
Topological domain | 190-213 | Extracellular | ||||
Sequence: LLDGSEPMCLFLAPFETYSAWALA | ||||||
Transmembrane | 214-235 | Helical; Name=5 | ||||
Sequence: VALSATILGFLLPFPLIAVFNI | ||||||
Topological domain | 236-254 | Cytoplasmic | ||||
Sequence: LSACRLRRQGQTESRRHCL | ||||||
Transmembrane | 255-276 | Helical; Name=6 | ||||
Sequence: LMWAYIVVFVICWLPYHVTMLL | ||||||
Topological domain | 277-295 | Extracellular | ||||
Sequence: LTLHTTHIFLHCNLVNFLY | ||||||
Transmembrane | 296-316 | Helical; Name=7 | ||||
Sequence: FFYEIIDCFSMLHCVANPILY | ||||||
Topological domain | 317-395 | Cytoplasmic | ||||
Sequence: NFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPLQRICTPTPSETCRPPLCLRTPHLHSAIP |
Keywords
- Cellular component
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069114 | 1-395 | G-protein coupled receptor 182 | |||
Sequence: MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIVVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPLQRICTPTPSETCRPPLCLRTPHLHSAIP | ||||||
Glycosylation | 24 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 33 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 122↔198 | |||||
Sequence: CRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMC | ||||||
Modified residue | 329 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in a wide variety of peripheral tissues in the adult rat with prominent expression in lung, testis, adrenal and liver.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length395
- Mass (Da)45,196
- Last updated2000-12-01 v3
- ChecksumDA0499C99E48128D
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A1L1I2 | A1L1I2_RAT | Gpr182 | 398 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 8-9 | in Ref. 3; AAA41271 | ||||
Sequence: RP → EA | ||||||
Sequence conflict | 40 | in Ref. 1; AAB05356 | ||||
Sequence: H → R | ||||||
Sequence conflict | 261 | in Ref. 3; AAA41271 | ||||
Sequence: V → A | ||||||
Sequence conflict | 264 | in Ref. 1; AAB05356 | ||||
Sequence: V → A | ||||||
Sequence conflict | 301 | in Ref. 1; AAB05356 | ||||
Sequence: I → T | ||||||
Sequence conflict | 366-395 | in Ref. 1; AAB05356 | ||||
Sequence: PLQRICTPTPSETCRPPLCLRTPHLHSAIP → LAAADLHTHAIRNVQASSLPPNTSPTLCNSIAS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L09249 EMBL· GenBank· DDBJ | AAB05356.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L04672 EMBL· GenBank· DDBJ | AAA41271.1 EMBL· GenBank· DDBJ | mRNA | ||
S79811 EMBL· GenBank· DDBJ | AAB35457.1 EMBL· GenBank· DDBJ | mRNA |