P31392 · GP182_RAT

  • Protein
    G-protein coupled receptor 182
  • Gene
    Gpr182
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Orphan receptor.

Caution

Was originally thought to be a receptor for adrenomedullin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionadrenomedullin receptor activity
Biological Processresponse to hypoxia

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    G-protein coupled receptor 182
  • Alternative names
    • G10D
    • NOW

Gene names

    • Name
      Gpr182
    • Synonyms
      Admr

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P31392
  • Secondary accessions
    • Q64166

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-53Extracellular
Transmembrane54-75Helical; Name=1
Topological domain76-86Cytoplasmic
Transmembrane87-109Helical; Name=2
Topological domain110-123Extracellular
Transmembrane124-145Helical; Name=3
Topological domain146-166Cytoplasmic
Transmembrane167-189Helical; Name=4
Topological domain190-213Extracellular
Transmembrane214-235Helical; Name=5
Topological domain236-254Cytoplasmic
Transmembrane255-276Helical; Name=6
Topological domain277-295Extracellular
Transmembrane296-316Helical; Name=7
Topological domain317-395Cytoplasmic

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000691141-395G-protein coupled receptor 182
Glycosylation24N-linked (GlcNAc...) asparagine
Glycosylation33N-linked (GlcNAc...) asparagine
Disulfide bond122↔198
Modified residue329Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in a wide variety of peripheral tissues in the adult rat with prominent expression in lung, testis, adrenal and liver.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    395
  • Mass (Da)
    45,196
  • Last updated
    2000-12-01 v3
  • Checksum
    DA0499C99E48128D
MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIVVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPLQRICTPTPSETCRPPLCLRTPHLHSAIP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A1L1I2A1L1I2_RATGpr182398

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict8-9in Ref. 3; AAA41271
Sequence conflict40in Ref. 1; AAB05356
Sequence conflict261in Ref. 3; AAA41271
Sequence conflict264in Ref. 1; AAB05356
Sequence conflict301in Ref. 1; AAB05356
Sequence conflict366-395in Ref. 1; AAB05356

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L09249
EMBL· GenBank· DDBJ
AAB05356.1
EMBL· GenBank· DDBJ
Genomic DNA
L04672
EMBL· GenBank· DDBJ
AAA41271.1
EMBL· GenBank· DDBJ
mRNA
S79811
EMBL· GenBank· DDBJ
AAB35457.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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