P31385 · DEP1_YEAST

Function

function

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Cellular ComponentRpd3L complex
Cellular ComponentRpd3L-Expanded complex
Cellular ComponentSin3-type complex
Molecular Functionhistone deacetylase binding
Biological Processcellular response to heat
Biological Processnegative regulation of inositol biosynthetic process
Biological Processnegative regulation of phosphatidylcholine biosynthetic process
Biological Processnegative regulation of phosphatidylserine biosynthetic process
Biological Processnegative regulation of rDNA heterochromatin formation
Biological Processnegative regulation of silent mating-type cassette heterochromatin formation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnucleosome assembly
Biological Processpositive regulation of inositol biosynthetic process
Biological Processpositive regulation of phosphatidylcholine biosynthetic process
Biological Processpositive regulation of phosphatidylserine biosynthetic process
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of DNA-templated DNA replication initiation
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional regulatory protein DEP1

Gene names

    • Name
      DEP1
    • Synonyms
      FUN54
    • Ordered locus names
      YAL013W

Organism names

Accessions

  • Primary accession
    P31385
  • Secondary accessions
    • D6VPK5
    • Q86ZS5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00000798641-405Transcriptional regulatory protein DEP1
Modified residue56Phosphoserine
Modified residue120Phosphoserine
Modified residue370Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P31385ASH1 P342332EBI-5755, EBI-3027

Complex viewer

View interactors in UniProtKB
View CPX-1852 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-26Disordered
Region49-171Disordered
Compositional bias84-139Basic and acidic residues
Compositional bias140-156Acidic residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    46,978
  • Last updated
    2011-07-27 v3
  • Checksum
    3A67F052C3920A22
MSQQTPQESEQTTAKEQDLDQESVLSNIDFNTDLNHNLNLSEYCISSDAGTEKMDSDEEKSLANLPELKYAPKLSSLVKQETLTESLKRPHEDEKEAIDEAKKMKVPGENEDESKEEEKSQELEEAIDSKEKSTDARDEQGDEGDNEEENNEEDNENENEHTAPPALVMPSPIEMEEQRMTALKEITDIEYKFAQLRQKLYDNQLVRLQTELQMCLEGSHPELQVYYSKIAAIRDYKLHRAYQRQKYELSCINTETIATRTFIHQDFHKKVTDLRARLLNRTTQTWYDINKERRDMDIVIPDVNYHVPIKLDNKTLSCITGYASAAQLCYPGEPVAEDLACESIEYRYRANPVDKLEVIVDRMRLNNEISDLEGLRKYFHSFPGAPELNPLRDSEINDDFHQWAQ

Sequence caution

The sequence AAC04944.2 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias84-139Basic and acidic residues
Compositional bias140-156Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L05146
EMBL· GenBank· DDBJ
AAC04944.2
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
AY260888
EMBL· GenBank· DDBJ
AAP21756.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006935
EMBL· GenBank· DDBJ
DAA06975.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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