P31374 · PSK1_YEAST
- ProteinSerine/threonine-protein kinase PSK1
- GenePSK1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1356 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Serine/threonine-protein kinase involved in the control of sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis.
Miscellaneous
Present with 967 molecules/cell in log phase SD medium.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | intracellular signal transduction | |
Biological Process | negative regulation of glycogen biosynthetic process | |
Biological Process | regulation of (1->6)-beta-D-glucan biosynthetic process | |
Biological Process | regulation of translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase PSK1
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP31374
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086042 | 1-1356 | Serine/threonine-protein kinase PSK1 | |||
Sequence: MPYIGASNLSEHSFVNLKEKHAITHKGTSSSVASLQTPPSPDQENHIDNELENYDTSLSDVSTPNKKEGDEFEQSLRDTFASFRKTKPPPPLDFEQPRLPSTASSSVDSTVSSPLTDEDIKELEFLPNESTHSYSYNPLSPNSLAVRLRILKRSLEIIIQNPSMLLEPTPDDLPPLKEFAGRRSSLPRTSASANHLMNRNKSQIWNTTSATLNAFVNNTSSSSAASSALSNKKPGTPVFPNLDPTHSQTFHRANSLAYLPSILPEQDPLLKHNNSLFRGDYGNNISPERPSFRQPFKDQTSNLRNSSLLNERAYQEDETFLPHHGPSMDLLNEQRANLKSLLNLLNETLEKNTSERASDLHMISLFNLNKLMLGDPKKNNSERDKRTEKLKKILLDSLAEPFFEHYNFIGDNPIADTDELKEEIDEFTGSGDTTAITDIRPQQDYGRILRTFTSTKNSAPQAIFTCSQEDPWQFRAANDLACLVFGISQNAIRALTLMDLIHTDSRNFVLHKLLSTEGQEMVFTGEIIGIVQPETLSSSKVVWASFWAKRKNGLLVCVFEKVPCDYVDVLLNLDDFGAENIVDKCELLSDGPTLSSSSTLSLPKMASSPTGSKLEYSLERKILEKSYTKPTSTENRNGDENQLDGDSHSEPSLSSSPVRSKKSVKFANDIKDVKSISQSLAKLMDDVRNGVVFDPDDDLLPMPIKVCNHINETRYFTLNHLSYNIPCAVSSTVLEDELKLKIHSLPYQAGLFIVDSHTLDIVSSNKSILKNMFGYHFAELVGKSITEIIPSFPKFLQFINDKYPALDITLHKNKGLVLTEHFFRKIQAEIMGDRKSFYTSVGIDGLHRDGCEIKIDFQLRVMNSKVILLWVTHSRDVVFEEYNTNPSQLKMLKESELSLMSSASSSASSSKKSSSRISTGTLKDMSNLSTYEDLAHRTNKLKYEIGDDSRAHSQSTLSEQEQVPLENDKDSGEMMLADPEMKHKLELARIYSRDKSQFVKEGNFKVDENLIISKISLSPSTESLADSKSSGKGLSPLEEEKLIDENATENGLAGSPKDEDGIIMTNKRGNQPVSTFLRTPEKNIGAQKHVKKFSDFVSLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKKPHENILRLLDFFEDDDYYYIETPVHGETGCIDLFDLIEFKTNMTEFEAKLIFKQVVAGIKHLHDQGIVHRDIKDENVIVDSKGFVKIIDFGSAAYVKSGPFDVFVGTIDYAAPEVLGGNPYEGQPQDIWAIGILLYTVVFKENPFYNIDEILEGDLKFNNAEEVSEDCIELIKSILNRCVPKRPTIDDINNDKWLVI | ||||||
Modified residue | 10 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 192 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 202 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 255 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 286 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 327 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 926 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1018 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1023 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1035 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1055 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1079 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P31374 | UGP1 P32861 | 4 | EBI-9442, EBI-19987 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 20-115 | Disordered | ||||
Sequence: KHAITHKGTSSSVASLQTPPSPDQENHIDNELENYDTSLSDVSTPNKKEGDEFEQSLRDTFASFRKTKPPPPLDFEQPRLPSTASSSVDSTVSSPL | ||||||
Compositional bias | 26-44 | Polar residues | ||||
Sequence: KGTSSSVASLQTPPSPDQE | ||||||
Compositional bias | 64-80 | Basic and acidic residues | ||||
Sequence: PNKKEGDEFEQSLRDTF | ||||||
Compositional bias | 98-114 | Polar residues | ||||
Sequence: RLPSTASSSVDSTVSSP | ||||||
Domain | 450-518 | PAS 1 | ||||
Sequence: RTFTSTKNSAPQAIFTCSQEDPWQFRAANDLACLVFGISQNAIRALTLMDLIHTDSRNFVLHKLLSTEG | ||||||
Region | 592-612 | Disordered | ||||
Sequence: PTLSSSSTLSLPKMASSPTGS | ||||||
Region | 627-660 | Disordered | ||||
Sequence: YTKPTSTENRNGDENQLDGDSHSEPSLSSSPVRS | ||||||
Domain | 738-807 | PAS 2 | ||||
Sequence: LKLKIHSLPYQAGLFIVDSHTLDIVSSNKSILKNMFGYHFAELVGKSITEIIPSFPKFLQFINDKYPALD | ||||||
Region | 948-972 | Disordered | ||||
Sequence: DSRAHSQSTLSEQEQVPLENDKDSG | ||||||
Region | 1021-1066 | Disordered | ||||
Sequence: TESLADSKSSGKGLSPLEEEKLIDENATENGLAGSPKDEDGIIMTN | ||||||
Domain | 1096-1354 | Protein kinase | ||||
Sequence: FVSLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKKPHENILRLLDFFEDDDYYYIETPVHGETGCIDLFDLIEFKTNMTEFEAKLIFKQVVAGIKHLHDQGIVHRDIKDENVIVDSKGFVKIIDFGSAAYVKSGPFDVFVGTIDYAAPEVLGGNPYEGQPQDIWAIGILLYTVVFKENPFYNIDEILEGDLKFNNAEEVSEDCIELIKSILNRCVPKRPTIDDINNDKWL |
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,356
- Mass (Da)152,332
- Last updated2011-07-27 v2
- Checksum9A2AF4A9C1785586
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-44 | Polar residues | ||||
Sequence: KGTSSSVASLQTPPSPDQE | ||||||
Compositional bias | 64-80 | Basic and acidic residues | ||||
Sequence: PNKKEGDEFEQSLRDTF | ||||||
Sequence conflict | 73 | in Ref. 1; no nucleotide entry, 2; no nucleotide entry, 3; no nucleotide entry and 4; AAC04940 | ||||
Sequence: E → Q | ||||||
Compositional bias | 98-114 | Polar residues | ||||
Sequence: RLPSTASSSVDSTVSSP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L05146 EMBL· GenBank· DDBJ | AAC04940.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006935 EMBL· GenBank· DDBJ | DAA06971.2 EMBL· GenBank· DDBJ | Genomic DNA |