P31269 · HXA9_HUMAN
- ProteinHomeobox protein Hox-A9
- GeneHOXA9
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids272 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951).
Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity).
Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity).
Features
Showing features for site, dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 163-164 | Breakpoint for translocation to form MSI2/HOXA9 fusion protein | ||||
Sequence: PV | ||||||
Site | 163-164 | Breakpoint for translocation to form the NUP98-HOXA9 fusion protein | ||||
Sequence: PV | ||||||
DNA binding | 206-265 | Homeobox | ||||
Sequence: TRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKIN |
GO annotations
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomeobox protein Hox-A9
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP31269
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Involvement in disease
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 140 | Results in loss of methylation. | ||||
Sequence: R → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 405 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000200081 | 1-272 | UniProt | Homeobox protein Hox-A9 | |||
Sequence: MATTGALGNYYVDSFLLGADAADELSVGRYAPGTLGQPPRQAATLAEHPDFSPCSFQSKATVFGASWNPVHAAGANAVPAAVYHHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE | |||||||
Modified residue | 140 | UniProt | Symmetric dimethylarginine | ||||
Sequence: R | |||||||
Modified residue (large scale data) | 161 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells (PubMed:22269951).
Interacts with EIF4E (By similarity).
Interacts with EIF4E (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P31269 | KRTAP9-3 Q9BYQ3 | 3 | EBI-742314, EBI-1043191 | |
BINARY | P31269 | PRMT5 O14744 | 4 | EBI-742314, EBI-351098 | |
BINARY | P31269 | TRIP6 Q15654 | 6 | EBI-742314, EBI-742327 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 155-198 | Disordered | ||||
Sequence: TDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAA |
Sequence similarities
Belongs to the Abd-B homeobox family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length272
- Mass (Da)30,172
- Last updated1999-07-15 v4
- Checksum823A1A22BB07A881
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A8MVF3 | A8MVF3_HUMAN | HOXA9 | 106 | ||
A0A669KBC8 | A0A669KBC8_HUMAN | HOXA9 | 213 | ||
A0A669K9T0 | A0A669K9T0_HUMAN | HOXA9 | 225 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 64 | in Ref. 1; AAB40867 | ||||
Sequence: G → V | ||||||
Sequence conflict | 67 | in Ref. 2; AAD08713 | ||||
Sequence: W → R | ||||||
Sequence conflict | 80 | in Ref. 1; AAB40867 | ||||
Sequence: Missing | ||||||
Sequence conflict | 243 | in Ref. 1; AAB40867 | ||||
Sequence: L → F |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U82759 EMBL· GenBank· DDBJ | AAB40867.1 EMBL· GenBank· DDBJ | mRNA | ||
AF010258 EMBL· GenBank· DDBJ | AAD08713.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT006990 EMBL· GenBank· DDBJ | AAP35636.1 EMBL· GenBank· DDBJ | mRNA | ||
AC004080 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC006537 EMBL· GenBank· DDBJ | AAH06537.1 EMBL· GenBank· DDBJ | mRNA | ||
BC010023 EMBL· GenBank· DDBJ | AAH10023.1 EMBL· GenBank· DDBJ | mRNA | ||
U41813 EMBL· GenBank· DDBJ | AAC50364.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |