P30920 · CDGT1_NIACI

Function

Catalytic activity

  • Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond.
    EC:2.4.1.19 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )
Note: Binds 2 calcium ions per subunit.

Features

Showing features for binding site, active site, site.

1718100200300400500600700
TypeIDPosition(s)Description
Binding site61Ca2+ 1 (UniProtKB | ChEBI)
Binding site63Ca2+ 1 (UniProtKB | ChEBI)
Binding site66Ca2+ 1 (UniProtKB | ChEBI)
Binding site67Ca2+ 1 (UniProtKB | ChEBI)
Binding site85Ca2+ 1 (UniProtKB | ChEBI)
Binding site87Ca2+ 1 (UniProtKB | ChEBI)
Binding site134-135substrate
Binding site173Ca2+ 2 (UniProtKB | ChEBI)
Binding site174substrate
Binding site224Ca2+ 2 (UniProtKB | ChEBI)
Binding site227-230substrate
Binding site230substrate
Binding site233Ca2+ 2 (UniProtKB | ChEBI)
Binding site261substrate
Active site263Nucleophile
Binding site266-267substrate
Binding site267Ca2+ 2 (UniProtKB | ChEBI)
Binding site267substrate
Active site291Proton donor
Binding site361substrate
Site362Transition state stabilizer
Binding site405substrate
Binding site409substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionalpha-amylase activity
Molecular Functioncyclomaltodextrin glucanotransferase activity
Molecular Functionmetal ion binding
Molecular Functionstarch binding
Biological Processcarbohydrate metabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

    • CBM20Carbohydrate-Binding Module Family 20
    • GH13Glycoside Hydrolase Family 13

Names & Taxonomy

Protein names

  • Recommended name
    Cyclomaltodextrin glucanotransferase
  • EC number
  • Alternative names
    • Cyclodextrin-glycosyltransferase (CGTase)

Organism names

Accessions

  • Primary accession
    P30920

Subcellular Location

Keywords

Phenotypes & Variants

Chemistry

    • DB017891-Amino-2,3-Dihydroxy-5-Hydroxymethyl Cyclohex-5-Ene
    • DB024694,6-dideoxy-4-amino-beta-D-glucopyranoside
    • DB018414,6-Dideoxyglucose
    • DB026704-Deoxy-Alpha-D-Glucose
    • DB021206-Amino-4-Hydroxymethyl-Cyclohex-4-Ene-1,2,3-Triol

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-34
ChainPRO_000000143035-718Cyclomaltodextrin glucanotransferase
Disulfide bond77↔84

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region35-172A1
Region173-236B
Region237-440A2
Region441-528C
Region529-614D
Domain532-612IPT/TIG
Domain613-718CBM20
Region615-718E

Domain

May consist of two protein domains: the one in the N-terminal side cleaves the alpha-1,4-glucosidic bond in starch, and the other in the C-terminal side catalyzes other activities, including the reconstitution of an alpha-1,4-glucosidic linkage for cyclizing the maltooligosaccharide produced.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    718
  • Mass (Da)
    78,047
  • Last updated
    1993-07-01 v1
  • Checksum
    E08CF0FE9C98BDA1
MFQMAKRAFLSTTLTLGLLAGSALPFLPASAVYADPDTAVTNKQSFSTDVIYQVFTDRFLDGNPSNNPTGAAYDATCSNLKLYCGGDWQGLINKINDNYFSDLGVTALWISQPVENIFATINYSGVTNTAYHGYWARDFKKTNPYFGTMADFQNLITTAHAKGIKIVIDFAPNHTSPAMETDTSFAENGRLYDNGTLVGGYTNDTNGYFHHNGGSDFSSLENGIYKNLYDLADFNHNNATIDKYFKDAIKLWLDMGVDGIRVDAVKHMPLGWQKSWMSSIYAHKPVFTFGEWFLGSAASDADNTDFANKSGMSLLDFRFNSAVRNVFRDNTSNMYALDSMINSTATDYNQVNDQVTFIDNHDMDRFKTSAVNNRRLEQALAFTLTSRGVPAIYYGTEQYLTGNGDPDNRAKMPSFSKSTTAFNVISKLAPLRKSNPAIAYGSTQQRWINNDVYVYERKFGKSVAVVAVNRNLSTSASITGLSTSLPTGSYTDVLGGVLNGNNITSTNGSINNFTLAAGATAVWQYTTAETTPTIGHVGPVMGKPGNVVTIDGRGFGSTKGTVYFGTTAVTGAAITSWEDTQIKVTIPSVAAGNYAVKVAASGVNSNAYNNFTILTGDQVTVRFVVNNASTTLGQNLYLTGNVAELGNWSTGSTAIGPAFNQVIHQYPTWYYDVSVPAGKQLEFKFFKKNGSTITWESGSNHTFTTPASGTATVTVNWQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X68326
EMBL· GenBank· DDBJ
CAA48401.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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